Effect of menthol on ocular drug delivery

Abstract

Menthol may improve the ocular penetration of a drug in a transcorneal and transscleral drug delivery system without causing toxic reactions.

Puerarin transport across a Calu-3 cell monolayer – an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol

“…Many researchers have reported the use of menthol as a penetration enhancer. 39 , 40 In previous in vivo studies, we have found that the brain targeting coefficient of puerarin combined with menthol and that the brain drug targeting index were significantly higher than those obtained with injections. 34 Through studying the influence of menthol on the mucosal permeability of puerarin in the abdominal skin of Rana catesbeiana as an in vitro model, we also found that when the mass concentration of menthol was 5 mg/mL after compatibility with puerarin was assessed, the P app value was significantly higher than that obtained in the puerarin alone group.…”

Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood–brain barrier in vitro model

“…Menthol is a naturally‐occurring cyclic terpene alcohol of plant origin, which frequently used in the preparation of topical analgesic, antipruritic and anti‐inflammatory drug, and as a penetration enhancer of drugs . Menthol is also as messenger drug performs a good penetration enhancer, such as enhancing permeation of drugs of skin, improving the drug delivery into the eye tissues and enhancing the gene transfer efficiency . The mechanism of menthol as a penetration enhancer is affecting intracellular lipids or proteins and loosens the epithelium junctions when present in high concentrations in the epithelium .…”

“…Menthol is also as messenger drug performs a good penetration enhancer, such as enhancing permeation of drugs of skin, improving the drug delivery into the eye tissues and enhancing the gene transfer efficiency . The mechanism of menthol as a penetration enhancer is affecting intracellular lipids or proteins and loosens the epithelium junctions when present in high concentrations in the epithelium . Combination therapies of TCM provided combined action on the treatment.…”

“…Menthol (1‐1‐methyl‐4‐isopropylcyclohexanol‐3, Figure c), as a messenger drug, which is considered to be capable of introducing the main effective drugs in the prescription to the target site to increase therapeutic efficacy has beneficial effect on ischaemic, cardiovascular and cerebrovascular disorders. Some reports have shown that menthol could enhance drug permeation through skin, improve the ocular penetration, increase the distribution of drugs in brain tissue and enhance gene transfer efficiency . Puerarin, paeoniflorin and menthol are the main active ingredients in a traditional Chinese herbal medicine recipe (Tong Qiao San Yu) that has been used clinically in the treatment of stroke with a certain efficacy.…”

Barrier, Adsorptive, and Mechanical Properties of Containers Molded from PET/PP Blends for Use in Pharmaceutical Solutions

“…In Japan, L-menthol is preferably included as an algefacient in over-the-counter eye drops [1]. Because L-menthol is a hydrophobic compound, it has a tendency to be adsorbed onto the walls of eye-drop containers, which are commonly made of polyolefin resin.…”