Effect of menstrual blood‐derived stromal stem cells on proliferative capacity of peripheral blood mononuclear cells in allogeneic mixed lymphocyte reaction

Nikoo, Shohreh; Ebtekar, Massoumeh; Jeddi-Tehrani, Mahmood; Shervin, Adel; Bozorgmehr, Mahmood; Kazemnejad, Somaieh; Zarnani, Amir Hassan

doi:10.1111/j.1447-0756.2011.01800.x

Cited by 49 publications

(31 citation statements)

References 17 publications

(24 reference statements)

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“…One published report indicates that MenSCs would exert opposite effects on the MLR response at different target: MenSCs ratios (22). This emphasizes the need for further studies providing insight into the mechanisms involved in this potentially new cell therapy-based application.…”

Section: Are Menscs Just Another Mscs Source?mentioning

confidence: 99%

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

et al. 2014

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Menstrual-derived stem cells (MenSCs) are a new source of mesenchymal stem cells isolated from the menstrual fluid. Currently, there is a growing interest in their clinical potential due to fact that they are multipotent, highly proliferative, and easy to obtain in a non-invasive manner. Sampling can be repeated periodically in a simplified and reproducible manner devoid of complications that no existing cell source can match. MenSCs are also free of ethical dilemmas, and display novel properties with regard to presently known adult derived stem cells. This review details their distinctive biological properties regarding immunophenotype and function, proliferation rate, differentiation potential, and paracrine effects mediated by secreted factors. Their possible role in antenatal diagnosis is also discussed. While more insight on their immunomodulatory and diagnostic properties is needed, the impact of clinical and epidemiological factors, such as age, use of contraceptives, or hormonal status still requires further investigations to properly assess their current and future use in clinical application and diagnosis.

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Section: Are Menscs Just Another Mscs Source?mentioning

confidence: 99%

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

et al. 2014

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“…In terms of laboratory processing, these cells can be selected by plastic adherence and in vitro expanded under standard culture conditions. The menstrual blood‐derived stromal stem cells display multipotent capabilities and immunomodulatory effects (Nikoo et al, ). Moreover, their immunomodulatory capacity has been found to be different when women with and without endometriosis were compared (Nikoo et al, ).…”

Section: Introductionmentioning

confidence: 99%

The immunomodulatory activity of extracellular vesicles derived from endometrial mesenchymal stem cells on CD4+ T cells is partially mediated by TGFbeta

Álvarez

Sánchez‐Margallo

Macías‐García

et al. 2018

J Tissue Eng Regen Med

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Endometrial mesenchymal stem cells (endMSCs) reside in the basal and functional layer of human endometrium and participate in tissue remodelling, which is required for maintaining the regenerative capacity of the endometrium. The endMSCs are multipotent stem cells and exhibit immunomodulatory effects. This paper aimed to evaluate the regulatory effects of extracellular vesicles derived from endMSCs (EV‐endMSCs) in the setting of T cell activation. In vitro stimulations of lymphocytes were performed in the presence of EV‐endMSCs. These in vitro‐stimulated lymphocytes were functionally and phenotypically characterized to distinguish CD4+ and CD8+ T cell differentiation subsets. Moreover, the inhibition of TGFβ was performed with neutralizing antibodies. The phenotype and nanoparticle tracking analysis of the EV‐endMSCs demonstrated that they are similar in terms of size distribution to other mesenchymal stem cells‐derived exosomes. The in vitro assays showed an immunomodulatory potential of these vesicles to counteract the differentiation of CD4+ T cells. The quantification of active TGFβ in EV‐endMSCs was found to be very high when compared with extracellular vesicles‐free concentrated supernatants. Finally, the neutralization of TGFβ significantly attenuated the immunomodulatory activity of EV‐endMSCs. In summary, this is the first report demonstrating that EV‐endMSCs exhibit a potent inhibitory effect against CD4+ T cell activation, which is partially mediated by TGFβ signalling.

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“…Menstruation takes place at the end of the secretory phase, when concentrations of ovarian steroid hormones drop down to their basal levels and their influence on local immune cells is mostly lost. In addition to their being a source for endometrial immune cells, in recent years much attention has been paid to menstrual blood (MB) as a source of multi‐potent stem cells . These studies have focused on the application of MB‐derived stem cells for regenerative medicine and cell therapy …”

Section: Introductionmentioning

confidence: 99%

Menstrual blood contains immune cells with inflammatory and anti‐inflammatory properties

Hosseini

Shokri

Tokhmechy

et al. 2015

J of Obstet and Gynaecol

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Effect of menstrual blood‐derived stromal stem cells on proliferative capacity of peripheral blood mononuclear cells in allogeneic mixed lymphocyte reaction

Abstract: According to the present study, MBSCs exert their immunoregulatory effects on allogeneic PBMCs in a dose-dependent manner. This finding can be considered as a valuable point in future cell therapy strategies, when this cell population is used.

Cited by 49 publications

References 17 publications

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy

The immunomodulatory activity of extracellular vesicles derived from endometrial mesenchymal stem cells on CD4+ T cells is partially mediated by TGFbeta

Menstrual blood contains immune cells with inflammatory and anti‐inflammatory properties

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