Effect of Meloxicam on Hematological and Kidney Histopathological Changes in Male Mice

Abstract

Introduction: Non-steroidal anti-inflammatory drugs are class of medications that frequently utilized as analgesic and anti-inflammatory therapy. Meloxicam is type of NSAIDs that classified as selective COX 2 inhibitor, which is considered more protective than traditional nonselective COX1 inhibitor. However, meloxicam was approved by other researches in recent years to cause renal damage. Aim of the Study: Therefore, the present study aimed to investigate effect of meloxicam on kidney of mice related with some blood parameter studies. Methods: Fifteen male mice were divided into two groups; one group of five mice served as control and received only distilled water. While the second group was treated with meloxicam 0.4 mg/kg which administrated daily by oral gastric gavage for 10 days. After 24 hours of the last dose animals were sacrificed, their kidneys were then removed and processed for histological Original Research Article