Effect of meloxicam administration after calving on milk production, acute phase proteins, and behavior in dairy cows

Mainau, Eva; Cuevas, A Ramos; Ruiz-de-la-Torre, J.L.; Abbeloos, E.; Manteca, Xavier

doi:10.1016/j.jveb.2014.07.007

Cited by 29 publications

(46 citation statements)

References 41 publications

(47 reference statements)

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“…Another NSAID, meloxicam, has been approved for use in cattle in many European countries as well as Canada. Past research has examined the effect of meloxicam administration in periparturient dairy cows with variable results (Newby et al, 2013;Mainau et al, 2014;Carpenter et al, 2016). Mainau et al (2014) found that postcalving meloxicam administration to eutocic primiparous animals resulted in an increase in activity for the first 2 d postcalving when compared with eutocic primiparous controls.…”

Section: Introductionmentioning

confidence: 99%

“…Past research has examined the effect of meloxicam administration in periparturient dairy cows with variable results (Newby et al, 2013;Mainau et al, 2014;Carpenter et al, 2016). Mainau et al (2014) found that postcalving meloxicam administration to eutocic primiparous animals resulted in an increase in activity for the first 2 d postcalving when compared with eutocic primiparous controls. Newby et al (2013) found that meloxicam-treated cows following a dystocic calving visited the feed bunk more often and spent more time feeding than control dystocic cows.…”

Section: Introductionmentioning

confidence: 99%

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Meloxicam administration either prior to or after parturition: Effects on behavior, health, and production in dairy cows

Swartz

Schramm

Bewley³

et al. 2018

Journal of Dairy Science

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Parturition is often a stressful period, when the incidence of disease is high after calving, which has been associated with an uncontrolled inflammatory response. Therefore, the objective of this study was to test the effect of the administration of a nonsteroidal anti-inflammatory drug (meloxicam) on the behavior, health, and production of peripartum cows. Meloxicam was dosed at 1 mg/kg of body weight, and an empty gel capsule served as a placebo. Both were administered orally with a balling gun. Dairy cows and heifers were randomly assigned to 1 of 3 treatment groups: (1) meloxicam administration before calving, with a placebo administered after calving (MEL-PRE, n = 60), (2) placebo administered before calving, and meloxicam administered after calving (MEL-POST, n = 69), and (3) a placebo administered before calving and after calving (CTL, n = 65). To identify imminent calving events, a vaginal thermometer was inserted approximately 2 wk before the expected calving date and a drop in temperature was used to identify cows close to calving. Calving events were monitored via video cameras, and the amount of time that elapsed between the appearance of the amniotic sac at the vulva until delivery of the calf was used to determine calving difficulty score. Eutocic calving events were defined as cows that calved in ≤70 min, and dystocia was defined as cows that took longer than 70 min to calve. Milk yield and components were measured for the first 15 wk of lactation and accelerometers were used to record activity and lying behaviors. The effects of treatment, breed, parity, calving difficulty, and, when applicable, a repeated measure, along with interaction terms, were analyzed in mixed models. Regardless of the time of administration, dystocic cattle that received meloxicam were less active than dystocic CTL. Dystocic animals displayed more lying bouts on the day of calving and then displayed fewer lying bouts and were less active during the days following calving. No effect of treatment was noted on any health outcomes. Eutocic MEL-PRE animals produced 6.8 kg/d more milk than eutocic CTL. Regardless of calving difficulty, MEL-PRE animals produced more milk fat, protein, and lactose (kg/d) than CTL. In conclusion, meloxicam administration before calving appears promising in increasing milk yield in eutocic cows.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meloxicam administration either prior to or after parturition: Effects on behavior, health, and production in dairy cows

Swartz

Schramm

Bewley³

et al. 2018

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…Difficulties during parturition are considered painful enough to administer analgesics post-partum, particularly in dairy cattle [60]. Cattle receiving post-partum analgesia tended to feed quicker [61,62] and resume activity sooner [63] compared with controls, highlighting the importance of considering the effect of parturition on animal welfare. There is limited literature on the use of analgesics in other farm species around the time of parturition, and of the effect of any assistance given during the birth if required.…”

Section: Parturitionmentioning

confidence: 99%

Why Pain Is Still a Welfare Issue for Farm Animals, and How Facial Expression Could Be the Answer

McLennan

2018

Agriculture

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Pain is a sensory and emotional experience that significantly affects animal welfare and has negative impacts on the economics of farming. Pain is often associated with common production diseases such as lameness and mastitis, as well as introduced to the animal through routine husbandry practices such as castration and tail docking. Farm animals are prey species which tend not to overtly express pain or weakness, making recognizing and evaluating pain incredibly difficult. Current methods of pain assessment do not provide information on what the animal is experiencing at that moment in time, only that its experience is having a long term negative impact on its behavior and biological functioning. Measures that provide reliable information about the animals' affective state in that moment are urgently required; facial expression as a pain assessment tool has this ability. Automation of the detection and analysis of facial expression is currently in development, providing further incentive to use these methods in animal welfare assessment.

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“…As Mainau et al (2014) note, calving is an inherently risky process in terms of both the health and welfare of the cow and calf and the overall economics. Accordingly, the authors evaluated the effects of the nonsteroidal anti-inflammatory meloxicam on physiological and behavioral measures of pain in postparturient cattle, given age, parity, and difficulty of birth and subsequent milk production, temperature, activity, and immunologic markers.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…Few processes are not multifactorial, and yet, we persist in testing simplistic models simply because we can. As Mainau et al (2014) demonstrate, understanding response surfaces is complex but important. Chapinal et al (2014) evaluate behavioral differences between primiparous and multiparous cows in milk production before abrupt cessation of routine milking (drying off) to end lactation.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Measuring stress, safety, and outcomes: Which measures are “good?”

Overall

2014

Journal of Veterinary Behavior

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Effect of meloxicam administration after calving on milk production, acute phase proteins, and behavior in dairy cows

Cited by 29 publications

References 41 publications

Meloxicam administration either prior to or after parturition: Effects on behavior, health, and production in dairy cows

Meloxicam administration either prior to or after parturition: Effects on behavior, health, and production in dairy cows

Why Pain Is Still a Welfare Issue for Farm Animals, and How Facial Expression Could Be the Answer

Measuring stress, safety, and outcomes: Which measures are “good?”

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