Effect of melatonin supplementation on endothelial function in heart failure with reduced ejection fraction: A randomized, double‐blinded clinical trial

Hoseini, Shervin Ghaffari; Heshmat-Ghahdarijani, Kiyan; Khosrawi, Saeid; Garakyaraghi, Mohammad; Shafie, Davood; Roohafza, Hamidreza; Mansourian, Marjan; Azizi, Elham; Gheisari, Yousof; Sadeghi, Masoumeh

doi:10.1002/clc.23682

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…Other studies have shown that melatonin improves outcomes in patients with heart failure and is considered a preventive and adjunctive curative measure in these patients [ 123 ]. A randomized double-blinded placebo-controlled clinical trial with two parallel arms using either placebo or oral 10 mg melatonin supplementation per day for twenty-four weeks in patients with heart failure and reduced ejection fraction observed improvements in endothelial function in those who did not also have diabetes [ 125 ].…”

Section: Clinical Usesmentioning

confidence: 99%

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich

Henning²,

Darley

et al. 2022

Nutrients

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Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. Research over the last decade into cancer, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, and many other conditions, combined with the COVID-19 pandemic, has led to greater awareness of melatonin because of its ability to act as a potent antioxidant, immune-active agent, and mitochondrial regulator. There are distinct similarities between melatonin and vitamin D in the depth and breadth of their impact on health. Both act as hormones, affect multiple systems through their immune-modulating, anti-inflammatory functions, are found in the skin, and are responsive to sunlight and darkness. In fact, there may be similarities between the widespread concern about vitamin D deficiency as a “sunlight deficiency” and reduced melatonin secretion as a result of “darkness deficiency” from overexposure to artificial blue light. The trend toward greater use of melatonin supplements has resulted in concern about its safety, especially higher doses, long-term use, and application in certain populations (e.g., children). This review aims to evaluate the recent data on melatonin’s mechanisms, its clinical uses beyond sleep, safety concerns, and a thorough summary of therapeutic considerations concerning dietary supplementation, including the different formats available (animal, synthetic, and phytomelatonin), dosing, timing, contraindications, and nutrient combinations.

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Section: Clinical Usesmentioning

confidence: 99%

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Minich

Henning²,

Darley

et al. 2022

Nutrients

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“…Investigasi terkait efek suplementasi melatonin terhadap fungsi endotel pada pasien gagal jantung dengan reduksi fraksi ejeksi telah dilakukan melalui penelitian randomized clinical trial (RCT) [14]. Pada penelitian tersebut, dilakukan penilaian disfungsi endotel terhadap pasien gagal jantung dengan menggunakan metode flow mediated dilatation (FMD).…”

Section: Temuan Potensi Suplemen Melatonin Untuk Gagal Jantungunclassified

“…Pada kasus gagal jantung, metode ini telah terbukti menjadi prediktor terhadap kejadian perburukan klinis, hospitalisasi, hingga kematian [22]. Penelitian [14] menyertakan 85 pasien yang dianalisis dengan pembagian 42 pasien mendapat intervensi suplemen melatonin dan 43 pasien penerima plasebo. Hasil yang didapatkan yakni adanya perbedaan yang signifikan pada nilai FMD pasca intervensi, perolehan menguntungkan didapatkan oleh kelompok melatonin sebesar 7,84% (6,68-8,98; 95% CI) dan 5,98% (4,84-7,12; 95% CI), P = 0,027 pada kelompok plasebo.…”

Section: Temuan Potensi Suplemen Melatonin Untuk Gagal Jantungunclassified

“…Hasil yang didapatkan berupa skor, semakin tinggi skor MLHFQ, maka merepresentasikan rendahnya kualitas hidup pasien. Nilai MLHFQ pasien yang menerima plasebo (mean 50,18 (SD 8,37)) lebih tinggi dibanding pasien yang mendapatkan suplemen melatonin (42,89 (10,14)), sehingga terdapat perbaikan kualitas hidup yang dirasakan oleh pasien (P < 0.05). Selanjutnya pengukuran status kelelahan pasien dilakukan melalui pengujian Fatigue Symptom Inventory (FSI) dengan interpretasi semakin rendah skor FSI, maka mengindikasikan rendahnya status kelelahan pasien.…”

Section: Temuan Potensi Suplemen Melatonin Untuk Gagal Jantungunclassified

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Potensi Efek Terapeutik Suplementasi Melatonin Terhadap Perbaikan Penyakit Gagal Jantung

Ida Ayu Yadnyaningtias Permata Sari,

Rini Noviyani

2023

WSNF

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Penyakit kardiovaskular menempati urutan tertinggi (35%) penyebab mortalitas di Indonesia dan mewakili 31% kematian global. Adapun salah satu penyakit kardiovaskular tersebut adalah gagal jantung. Gagal jantung dikenal sebagai sindrom klinis dengan gejala kompleks yang diakibatkan oleh abnormalitas fungsi jantung sebagai pemompa darah dan oksigen bagi tubuh. Menurut data yang diperoleh dari Riset Kesehatan Dasar (Riskesdas) tahun 2013, prevalensi kejadian gagal jantung di Indonesia adalah 0,3%. Terjadinya peningkatan prevalensi dan mortalitas akibat gagal jantung dapat disebabkan oleh progresivitas perburukan penyakit. Berkaitan dengan manajemen penanganan penyakit gagal jantung, terapi suportif penunjang perbaikan gagal jantung dapat dilakukan dengan pemberian nutrasetikal, termasuk suplemen melatonin. Tujuan penulisan artikel ini adalah untuk mengetahui perkembangan lebih mendalam terkait luaran klinis pemberian suplemen melatonin pada penyakit gagal jantung. Metode pembuatan artikel dilakukan dengan meninjau berbagai literatur ilmiah yang dicari melalui penelusuran empat database, yaitu PubMed, ScienceDirect, Cochrane Library, dan Google Scholar. Artikel yang termasuk kriteria inklusi selanjutnya dianalisis dan disajikan secara naratif. Hasil kajian pustaka menunjukkan bahwa dari berbagai studi eksperimental yang ada, melatonin memiliki potensi yang bermanfaat secara klinis dalam perbaikan fungsi endotelium dan penurunan kadar serum NT-Pro BNP. Pemberian suplemen melatonin juga memberikan dampak positif terhadap peningkatan kualitas hidup dan nafsu makan, serta penurunan status kelelahan hingga insiden delirium pada pasien gagal jantung.

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“…Therefore, melatonin should be considered as an important element of MT and CT of cardiovascular disorders. In recently published paper, evaluation of the effect of melatonin on endothelial function in HF explored that oral melatonin for 24 weeks had a beneficial effect on endothelial function in patients with HF with reduced ejection fraction (HFrEF) ( 499 ).…”

Section: Clinical Trials Using Melatonin For Cardiovascular Diseasesmentioning

confidence: 99%

Evidence for the Benefits of Melatonin in Cardiovascular Disease

Tobeiha

Jafari

Fadaei

et al. 2022

Front. Cardiovasc. Med.

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The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle. Melatonin has been shown to possess anti-oxidant activity and neuroprotective properties. Numerous studies have shown that melatonin has significant functions in cardiovascular disease, and may have anti-aging properties. The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated. Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion in rodent species. Moreover, melatonin may also prevent the hypertrophy of the heart muscle under some circumstances, which in turn would lessen the development of heart failure. Several currently used conventional drugs show cardiotoxicity as an adverse effect. Recent rodent studies have shown that melatonin acts as an anti-oxidant and is effective in suppressing heart damage mediated by pharmacologic drugs. Therefore, melatonin has been shown to have cardioprotective activity in multiple animal and human studies. Herein, we summarize the most established benefits of melatonin in the cardiovascular system with a focus on the molecular mechanisms of action.

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Effect of melatonin supplementation on endothelial function in heart failure with reduced ejection fraction: A randomized, double‐blinded clinical trial

Cited by 9 publications

References 28 publications

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Potensi Efek Terapeutik Suplementasi Melatonin Terhadap Perbaikan Penyakit Gagal Jantung

Evidence for the Benefits of Melatonin in Cardiovascular Disease

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