Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer

Jardim‐Perassi, Bruna V.; Arbab, Ali S.; Ferreira, Lívia Carvalho; Borin, Thaiz F.; Varma, Nadimpalli Ravi S.; Iskander, Asm; Shankar, Adarsh; Ali, Meser M.; Zuccari, Débora Aparecida Pires de Campos

doi:10.1371/journal.pone.0085311

Cited by 148 publications

(132 citation statements)

References 58 publications

(79 reference statements)

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Melatonin also inhibits other tumor growth factors, such as IGF and EGF, which are strong mitogens that stimulate tumor angiogenesis [102,104]. Therefore, melatonin seems to suppress cancer angiogenesis through several complementary mechanisms.…”

Section: Anti-angiogenic Activitymentioning

confidence: 99%

Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance

Cardinali¹,

Escames²,

Acuña-Castroviejo³

et al. 2016

J Integr Oncol

View full text Add to dashboard Cite

Section: Anti-angiogenic Activitymentioning

confidence: 99%

Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance

Cardinali¹,

Escames²,

Acuña-Castroviejo³

et al. 2016

J Integr Oncol

View full text Add to dashboard Cite

“…While it was revealed that melatonin regulates KiSS1 expression in the hypothalamus in the brain (26,27), an association between melatonin and KiSS1 in cancer has not been identified. While 1 mM melatonin treatment inhibited metastatic functions, including migration and invasion in triple-negative MDA-MB-231 breast cancer cell lines, the pharmacological concentration of melatonin also reduced the cell viability and caused apoptosis (28)(29)(30). In addition, physiological concentrations of melatonin only reduced the viabilities of less invasive, non-triple-negative breast cancer cells (28,31,32), which may be due to different MT1 expression levels in less or highly invasive breast cancer cells (33).…”

Section: Introductionmentioning

confidence: 99%

Melatonin-induced KiSS1 expression inhibits triple-negative breast cancer cell invasiveness

Kim

Cho

2017

Oncology Letters

View full text Add to dashboard Cite

Abstract. Breast cancer is one of the most common types of cancer in women, and its metastasis increases the risk of mortality. Melatonin, a hormone that regulates the circadian rhythm, has been revealed to inhibit breast cancer growth and metastasis. However, its involvement in highly metastatic triple-negative breast cancer cells is yet to be elucidated. The present study demonstrated that melatonin inhibited the metastatic abilities of triple-negative breast cancer cells and prolonged its inhibitory effect via the expression of kisspeptin (KiSS1), which is a suppressor of metastasis. Melatonin at concentrations ranging from 1 nM to 10 µM did not affect the proliferation of metastatic MDA-MB-231 and HCC-70 triple-negative breast cancer cells. However, melatonin repressed invasiveness in triple-negative breast cancer cells. Additionally, conditional medium from melatonin-treated MDA-MB-231 cells repressed the invasiveness of triple-negative breast cancer cells. Melatonin promoted the production of KiSS1, a metastasis suppressor encoded by the KiSS1 gene. In addition, melatonin increased KiSS1 expression via the expression and transcriptional activation of GATA binding protein 3. Silencing of KiSS1 weakened melatonin inhibition of breast cancer cell invasiveness. Therefore, the present study concluded that melatonin activates KiSS1 production in metastatic breast cancer cells, suggesting that melatonin activation of KiSS1 production may regulate the process of breast cancer metastasis.

show abstract

“…Here we have evaluated the ultrastructural changes occurring in the human alveolar RH30 cells upon administration of Mel dissolved either in EtOH (Salucci et al, 2014a) or DMSO (Jardim-Perassi et al, 2014) …”

Section: Introductionmentioning

confidence: 99%

Melatonin action in tumor skeletal muscle cells: an ultrastructural study

et al. 2016

View full text Add to dashboard Cite

a b s t r a c t Melatonin (Mel), or N-acetyl-5-methoxytryptamine, is a circadian hormone that can diffuse through all the biological membranes thanks to its amphiphilic structure, also overcoming the blood-brain barrier and placenta. Although Mel has been reported to exhibit strong antioxidant properties in healthy tissues, studies carried out on tumor cultures gave a different picture of its action, often describing Mel as effective to trigger the cell death of tumor cells by enhancing oxidative stress.Based on this premise, here Mel effect was investigated using a tumor cell line representative of the human alveolar rhabdomyosarcoma (ARMS), the most frequent soft tissue sarcoma affecting childhood. For this purpose, Mel was given either dissolved in ethanol (EtOH) or dimethyl sulfoxide (DMSO) at different concentrations and time exposures. Cell viability assays and ultrastructural observations demonstrated that Mel was able to induce a dose-and time-dependent cell death independently on the dissolution solvent. Microscopy analyses highlighted the presence of various apoptotic and necrotic patterns correlating with the increasing Mel dose and time of exposure. These findings suggest that Mel, triggering apoptosis in ARMS cells, could be considered as a promising drug for future multitargeted therapies.

show abstract

Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer

Cited by 148 publications

References 58 publications

Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance

Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance

Melatonin-induced KiSS1 expression inhibits triple-negative breast cancer cell invasiveness

Melatonin action in tumor skeletal muscle cells: an ultrastructural study

Contact Info

Product

Resources

About