Effect of Melatonin on Tinnitus

Rosenberg, Seth I.; Silverstein, Herbert; Rowan, P T; Olds, M J

doi:10.1097/00005537-199803000-00001

Cited by 71 publications

(59 citation statements)

References 8 publications

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“…83 Some researchers have suggested that increasing intake of various dietary components, particularly vitamin B, zinc, and magnesium, could help tinnitus. Existing evidence is of poor quality and contradictory, although magnesium and several other vitamins and minerals are being investigated as potential otoprotectants.…”

Section: Drug Treatmentsmentioning

confidence: 99%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

1,012

911

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Tinnitus is a common medical symptom that can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury, and depression. At presentation, the possibilities of otological disease, anxiety, and depression should be considered. No eff ective drug treatments are available, although much research is underway into mechanisms and possible treatments. Surgical intervention for any otological pathology associated with tinnitus might be eff ective for that condition, but the tinnitus can persist. Available treatments include hearing aids when hearing loss is identifi ed (even mild or unilateral), wide-band sound therapy, and counselling. Cognitive behavioural therapy (CBT) is indicated for some patients, but availability of tinnitus-specifi c CBT in the UK is poor. The evidence base is strongest for a combination of sound therapy and CBT-based counselling, although clinical trials are constrained by the heterogeneity of patients with tinnitus.

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Section: Drug Treatmentsmentioning

confidence: 99%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

1,012

911

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“…214 Only 1 study reported possible adverse effects of melatonin, which included bad dreams and fatigue. 215 …”

Section: Melatoninmentioning

confidence: 99%

Clinical Practice Guideline: Tinnitus

Tunkel¹,

Bauer

Sun

et al. 2014

Otolaryngol.--head neck surg.

550

408

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“…Melatonin is the hormone secreted by the pineal gland and connected with cyclic activities. It has been proposed for tinnitus treatment [18] .…”

Section: Tinnitus As a Circadian System Disordermentioning

confidence: 99%

Tinnitus as an Alarm Bell: Stress Reaction Tinnitus Model

Alpini

Cesarani

2006

ORL

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Stress is a significant factor influencing the clinical course of tinnitus. Auditory system is particularly sensitive to the effects of different stress factors (chemical, oxidative, emotional, etc.). Different stages of reaction (alarm, resistance, exhaustion) lead to different characteristics of tinnitus and different therapeutic approaches. Individual characteristics of stress reaction may explain different aspects of tinnitus in various patients with different responses to treatment, despite similar audiological and ethiological factors. A model based on individual reactions to stress factors (stress reaction tinnitus model) could explaintinnitus as an alarm signal, just like an ‘alarm bell’, informing the patient that something potentially dangerous for subject homeostasis is happening. Tinnitus could become a disabling symptom when the subject is chronically exposed to a stress factor and is unable to switch off the alarm. Stress signals, specific for each patient, have to be identified during the ‘alarm’ phase in order to prevent an evolution toward the ‘resistance’ and ‘exhaustion’ phases. In these phases, identification of stressor is no more sufficient, due to the organization of a ‘paradoxical auditory memory’ and a ‘pathologically shifted attention to tinnitus’. Identification of stress reaction phase requires accurate otolaryngology and anamnesis combined with audiological matching tests (Feldman Masking Test, for example) and psychometric questionnaires (Tinnitus Reaction and Tinnitus Cognitive Questionnaires).

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Effect of Melatonin on Tinnitus

Cited by 71 publications

References 8 publications

Tinnitus

Tinnitus

Clinical Practice Guideline: Tinnitus

Tinnitus as an Alarm Bell: Stress Reaction Tinnitus Model

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