Effect of melatonin on sleep disorders in a monkey model of Parkinson's disease

Belaïd, Hayat; Adrien, Joëlle; Karachi, Carine; Hirsch, Étienne C.; François, Chantal

doi:10.1016/j.sleep.2015.06.018

Cited by 27 publications

(22 citation statements)

References 28 publications

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“…Addition of melatonin (10 μg/kg) 2 h before bedtime to ongoing levodopa treatment resulted in longer sleep times and higher sleep efficiency compared to the untreated state, but not compared to levodopa alone [85].…”

Section: What Is the Evidence That Melatonin Is Helpful In Animal Modmentioning

confidence: 97%

“…In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) macaque model of PD, monkeys exhibited sleep disorders reminiscent of human PD, including disrupted night sleep and intrusion of sleep into day [85]. Addition of melatonin (10 μg/kg) 2 h before bedtime to ongoing levodopa treatment resulted in longer sleep times and higher sleep efficiency compared to the untreated state, but not compared to levodopa alone [85].…”

Section: What Is the Evidence That Melatonin Is Helpful In Animal Modmentioning

confidence: 99%

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Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases

Trotti

Karroum

2016

Curr Neurol Neurosci Rep

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In patients with neurodegenerative diseases, sleep disorders are common; they impair the quality of life for patients and caregivers and are associated with poorer clinical outcomes. Melatonin has circadian, hypnotic, and free radical-scavenging effects, and preclinical data suggest benefits of melatonin on neurodegeneration. However, randomized, controlled trials of melatonin in patients with neurodegenerative diseases have not shown strong effects. Trials in Alzheimer's patients demonstrate a lack of benefit on sleep quantity. Subjective measures of sleep quality are mixed, with possible symptomatic improvements seen only on some measures or at some time points. Benefits on cognition have not been observed across several studies. In Parkinson's patients, there may be minimal benefit on objective sleep measures, but a suggestion of subjective benefit in few, small studies. Effective treatments for the sleep disorders associated with neurodegenerative diseases are urgently needed, but current data are insufficient to establish melatonin as such a treatment.

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Section: What Is the Evidence That Melatonin Is Helpful In Animal Modmentioning

confidence: 97%

Section: What Is the Evidence That Melatonin Is Helpful In Animal Modmentioning

confidence: 99%

Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases

Trotti

Karroum

2016

Curr Neurol Neurosci Rep

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“…Oral doses given 2 hours before light offset led to significantly earlier sleep onset and longer periods of sleep compared to vehicle-treated monkeys (Zhdanova et al, 2002). Additionally, MPTP-treated monkeys, an animal model of Parkinson’s disease, showed reduced sleep disruption with melatonin (Belaid et al, 2015). These findings suggest that melatonin might be an effective treatment for monkeys with SIB by accelerating sleep onset and reducing nighttime activity.…”

Section: Discussionmentioning

confidence: 99%

Rhesus macaques ( Macaca mulatta ) displaying self-injurious behavior show more sleep disruption than controls

Stanwicks

Hamel

Novak

2017

Applied Animal Behaviour Science

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Self-injurious behavior (SIB) is a pathology observed in both humans and animals. In humans, SIB has been linked to various mental health conditions that are also associated with significant sleep disruption. In rhesus macaques, SIB consists of self-directed biting which can range from mild skin abrasions to wounds requiring veterinary care. However, only one study suggests possible sleep disruption in macaques with SIB. We evaluated sleep disruption using a noninvasive system (infra-red camera and a video surveillance program) which created videos for every movement over the nighttime hours. Nighttime activity was examined in 13 macaques (three females) of which six were classified as having SIB (one female). Each monkey was studied for a total of 6 nights spanning a period of 4 months. Measures included total movement time (TMT), time moving in the first hour (HR1), time moving in the last hour (HR11), and number of videos <10 secs, ≥10 secs, and ≥30 secs in length. Overall, SIB monkeys had higher TMT (p < 0.01), higher HR1 (p<0.001), and generated more videos ≥10 secs (p < 0.01) and ≥30 secs (p < 0.01). Thus, SIB monkeys showed significant sleep disruption. A four-fold difference between SIB and control monkeys in the ≥30 secs videos revealed many more significant awakenings in the SIB group. Overall higher nighttime activity, in the first hour but not in the last hour, is consistent with sleep-onset insomnia in humans. Whether increased nighttime activity contributes to the SIB condition during the day or, conversely, SIB causes higher nighttime activity remains undetermined.

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“…Esumi et al reported the sleep deprivation induces neurodegeneration through upregulating several inflammatory factors including IL-6 and TNF-α [44]. Indeed, LPS administration changes the sleep-wake cycle in rats, increases slow wave sleep (SWS) and decreases wakefulness, and more importantly, LPS interferes with REM sleep [45–48]. Although the underlying mechanisms are still poorly understood, evidence has shown that inflammation may play an important role in the association between RBD and PD development.…”

mentioning

confidence: 99%

“…Recently, melatonin has been considered as a pharmacological strategy for sleep disorders in PD in several clinical studies [48]. Melatonin plays a key role in the circadian regulation of the sleep/wake cycle and is also a strong antioxidant which can protect against neural damage from oxidative stress and inflammation [48].…”

mentioning

confidence: 99%