Effect of Melatonin on Intracranial Pressure and Brain Edema Following Traumatic Brain Injury: Role of Oxidative Stresses

Dehghan, Fatemeh; Khaksari, Mohammad; Asadikram, Gholamreza; Najafipour, Hamid; Shahrokhi, Nader

doi:10.1016/j.arcmed.2013.04.002

Cited by 60 publications

(48 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prevention of elevation of ICP by soy may be due to the prevention of the vasogenic edema development [53]. The deterioration of neurologic outcome post-trauma was observed on trauma day, and continued until 48 h post-trauma in our research, consistent with other study [44]. The brain edema is a major cause of the neurological deterioration following TBI [40].…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?

Soltani¹,

Khaksari²

2014

J Neurol Neurophysiol

View full text Add to dashboard Cite

Our previous studies have demonstrated that estrogen is protective in traumatic brain injury (TBI). However, concerns about negative consequences of estrogen therapy have led to find other strategies to obtain estrogen's benefits in the brain, including the use of a soy diet. This study was designed to determine whether a soy diet is protective in TBI. The male Albino N-Mary rats received either a soy-free diet (SFD) or soy diet (SD) from weaning to adulthood. The SFD and SD rats were separately divided to two groups of sham and TBI (n= 18 in each group). The diffuse and severe brain injury was induced by Marmarou method. The disruption of Blood brain-barrier (BBB) was evaluated 48 h post-TBI. The intracranial pressure (ICP), the neurologic outcome, and the beam-walk task (WB) were determined before trauma, on trauma day (D0), and first (D1) and second (D2) days post-TBI. Evans blue dye was significantly high in the SFD + TBI group vs. other groups. The ICP was significantly high in the SFD + TBI group in all times evaluated, and in the SD + TBI group on D1 and D2, however lower than that in the former group. The neurologic outcome score was significantly low in the SFD + TBI group vs. the sham groups in all times. Also the traversal time in WB task was significantly high in the SFD + TBI group not the SD + TBI group, vs. the sham groups in all times, however significant difference of distance traveled was shown only on trauma day. The results of this study demonstrate that soy diet can prevent the disruption of BBB, and attenuate the elevation of ICP, and the disturbance of vestibulomotor and neurologic performance in TBI.

show abstract

Section: Discussionsupporting

confidence: 81%

“…The controlling of ICP is recommended in TBI patients [43]. In present study, the elevation of ICP was initiated one hour after trauma, and continued for 48 h consistent with our other studies [25,44]. The results of our research indicated that soy diet prevented the increase of ICP on trauma day (first hour).…”

Section: Discussionsupporting

confidence: 80%

Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?

Soltani¹,

Khaksari²

2014

J Neurol Neurophysiol

View full text Add to dashboard Cite

show abstract

“…Neurological disorders which have been reported to be improved by administration of melatonin are as follows: Parkinsonism [10], Alzheimer's disease [11], brain edema and traumatic brain injury [12], alcoholism [13], depression [14], cerebral ischemia [15], hyperhomocysteinuria [16], glioma [17] and phenylketonuria [18]. Alzheimer's disease is an age-related progressive neurodegenerative disorder, characterized with loss of cognitive functions, dementia and other neurobiological findings [2,19].…”

Section: öZmentioning

confidence: 99%

A Review of Melatonin, Its Receptors and Drugs

et al. 2016

View full text Add to dashboard Cite

After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine. Melatonin, a hormone secreted from the pineal gland at night, plays roles in regulating sleep-wake cycle, pubertal development and seasonal adaptation. Melatonin has antinociceptive, antidepressant, anxiolytic, antineophobic, locomotor activityregulating, neuroprotective, anti-inflammatory, pain-modulating, blood pressure-reducing, retinal, vascular, anti-tumor and antioxidant effects. It is related with memory, ovarian physiology, and osteoblast differentiation. Pathologies associated with an increase or decrease in melatonin levels are summarized in the review. Melatonin affects by four mechanisms: 1) Binding to melatonin receptors in plasma membrane, 2) Binding to intracellular proteins such as calmoduline, 3) Binding to Orphan nuclear receptors, and 4) Antioxidant effect. Receptors associated with melatonin are as follows: 1) Melatonin receptor type 1a: MT1 (on cell membrane), 2) Melatonin receptor type 1b: MT2 (on cell membrane), 3) Melatonin receptor type 1c (found in fish, amphibians and birds), 4) Quinone reductase 2 enzyme (MT3 receptor, a detoxification enzyme), 5) RZR/RORα: Retinoid-related Orphan nuclear hormone receptor (with this receptor, melatonin binds to the transcription factors in nucleus), and 6) GPR50: X-linked Melatonin-related Orphan receptor (it is effective in binding of melatonin to MT1). Melatonin agonists such as ramelteon, agomelatine, circadin, TIK-301 and tasimelteon are introduced and side effects will be discussed. In conclusion, melatonin and related drugs is a new and promising era for medicine. Melatonin receptors and melatonin drugs will take attention with greater interest day by day in the future. Keywords: Melatonin, receptors, agonists, pineal gland ÖzSaat genlerini anlamamıza olan katkısından dolayı bir Türk bilim adamı Nobel ödülünü aldıktan sonra, bu genlerle yakın ilişkili olan melatoninin önemi arttı. Melatonin, pineal bezden gece salınan bir hormondur, uyku/uyanıklık döngüsünde, pubertal gelişimde ve mevsimsel adaptasyonda rol alır. Melatoninin antinosiseptif, antidepresan, anksiyolitik, antineofobik, locomotor aktiviteyi düzenleyici, nöroprotektif, antiinflamatuvar, ağrı dü-zenleyici, kan basıncını düşürücü, retinal, vasküler, tümör baskılayıcı ve antioksidan etkileri vardır. Hafıza, over fizyolojisi ve osteoblast diferansiasyonuyla ilişkilidir. Melatonin seviyelerinde artış veya azalışla seyreden patolojiler derlemede özetlenmiştir. Melatonin 4 mekanizmayla etkir: 1) Plazma membranında melatonin reseptörlerine bağlanma, 2) Kalmodulin gibi hücre içi reseptörlere bağlanma, 3) Yetim nükleer reseptörlere bağlanma, 4) Antioksidan etkiler. Melatoninle ilişkili reseptörler şunlardır: 1) Melatonin reseptör tip1a: MT1 (hücre zarında), 2) Melatonin reseptör tip1b: MT2 (hücre zarında), 3) Melatonin reseptör tip1c (balık, amfibiler ve kuşlarda bulunur), 4) Kuinon redüktaz-2 enzimi (MT3 reseptörü, bir detoksifika...

show abstract

“…It has been recognized that melatonin administration in both low and high doses can significantly decrease brain edema and blood-brain barrier permeability at 72 h after TBI. Moreover, this inhibitory effect is associated with improvement of neurologic scores (60).…”

Section: Melatoninmentioning

confidence: 99%

Antioxidant therapies in traumatic brain injury: a review

Romero-Rivera¹,

Cabeza-Morales²,

Soto-Zarate³

et al. 2017

Romanian Neurosurgery

View full text Add to dashboard Cite

Abstract:Oxidative stress constitute one of the commonest mechanism of the secondary injury contributing to neuronal death in traumatic brain injury cases. The oxidative stress induced secondary injury blockade may be considered as to be a good alternative to improve the outcome of traumatic brain injury (TBI) treatment. Due to absence of definitive therapy of traumatic brain injury has forced researcher to utilize unconventional therapies and its roles investigated in the improvement of management and outcome in recent year. Antioxidant therapies are proven effective in many preclinical studies and encouraging results and the role of antioxidant mediaction may act as further advancement in the traumatic brain injury management it may represent aonr of newer moadlaity in neurosurgical aramamentorium, this kind of therapy could be a good alternative or adjuct to the previously established neuroprotection agents in TBI.

show abstract

Effect of Melatonin on Intracranial Pressure and Brain Edema Following Traumatic Brain Injury: Role of Oxidative Stresses

Cited by 60 publications

References 74 publications

Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?

Can Soy Diet be Protective in Severe and Diffuse Traumatic Brain Injury?

A Review of Melatonin, Its Receptors and Drugs

Antioxidant therapies in traumatic brain injury: a review

Contact Info

Product

Resources

About