“…Increased serum MT level in footballers and in rowers after a 30-day MT intake. Reduced OS markers: MDA, IL-6, CRP, and low-density lipoproteins Supplementation of MT in professional athletes during intense training may protect against the toxic action of ROS/RNS and inflammation | Souissi et al 2018 [ 121 ] | Eight healthy moderately trained male students, mean age: 21.8 ± 0.9 years | 6 mg MT supplementation or placebo at 09:00 a.m. in a randomized order 50 min before exercise | Running at 60% for 45 min on a treadmill, starting at a speed of 8 km/h and increasing by 0.5 km/h after every minute | Exercise elevated inflammatory markers: CRP, LDH, ALAT, ASAT in both placebo or MT intake groups | MT ingestion before moderate prolonged submaximal exercise showed no anti-inflammatory action |
Cheikh et al 2020 [ 124 ] | Randomized double-blind trial of 14 healthy-trained male athletes, mean age 154 ± 0.3 years | 10 mg MT or placebo ingestion (control) after vigorous late-evening exercise (10:00 p.m.) | Two-test sessions (separated at least one week) Running-Based Anaerobic Sprint Test at 8:00 p.m. and in the following morning (7:30 a.m.) | Reductions of: WBC, NE, LY, CRP, muscle and hepatic damage enzymes (CK, ASAD), LDH, MDA and homocysteine before and after strenuous exercise vs placebo group | MT intake after strenuous late-evening exercise diminished transient leukocytosis and protected against lipid peroxidation and muscle damage in teenage athletes |
Farjallach et al 2019 [ 125 ] | 20 soccer players mean age 18.81 ± 1.3 years, MT group ( n = 10), placebo group ( n = 10) | Nocturnal oral MT (5 mg) or placebo ingestion in a double-blind manner | Intensive 6-day training-repeated sprint ability test: sprints 6 × 40 m with a 20 s of passive recovery between repetitions | Decreased resting OS markers: AOPP, leukocytosis and CK. Decreased post-exercise leukocytosis and markers of cellular damage (CK, ASAT, ALAT), increased GPx and GR activities in MT-treated group vs placebo group | Nocturnal MT intake during intensive training decreased OS, leukocytosis, cellular damage, and improved exercise performance |
LY lymphocytes, WBC white blood cells, NE neutrophils, CRP C-reactive protein, CK creatine kinase, LDH lactate dehydrogenase, ASAT aspartate aminotransferase, MDA malonaldehyde, LDL low-density lipoprotein, maximal oxygen uptake, ALAT alanine aminotransferase, CHO formaldehyde, ORAC oxygen radical absorption capacity, LPO ...…”