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2018
DOI: 10.1080/09291016.2018.1543638
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Effect of melatonin on inflammatory response to prolonged exercise

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Cited by 10 publications
(24 citation statements)
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“…Increased serum MT level in footballers and in rowers after a 30-day MT intake. Reduced OS markers: MDA, IL-6, CRP, and low-density lipoproteins Supplementation of MT in professional athletes during intense training may protect against the toxic action of ROS/RNS and inflammation Souissi et al 2018 [ 121 ] Eight healthy moderately trained male students, mean age: 21.8 ± 0.9 years 6 mg MT supplementation or placebo at 09:00 a.m. in a randomized order 50 min before exercise Running at 60% for 45 min on a treadmill, starting at a speed of 8 km/h and increasing by 0.5 km/h after every minute Exercise elevated inflammatory markers: CRP, LDH, ALAT, ASAT in both placebo or MT intake groups MT ingestion before moderate prolonged submaximal exercise showed no anti-inflammatory action Cheikh et al 2020 [ 124 ] Randomized double-blind trial of 14 healthy-trained male athletes, mean age 154 ± 0.3 years 10 mg MT or placebo ingestion (control) after vigorous late-evening exercise (10:00 p.m.) Two-test sessions (separated at least one week) Running-Based Anaerobic Sprint Test at 8:00 p.m. and in the following morning (7:30 a.m.) Reductions of: WBC, NE, LY, CRP, muscle and hepatic damage enzymes (CK, ASAD), LDH, MDA and homocysteine before and after strenuous exercise vs placebo group MT intake after strenuous late-evening exercise diminished transient leukocytosis and protected against lipid peroxidation and muscle damage in teenage athletes Farjallach et al 2019 [ 125 ] 20 soccer players mean age 18.81 ± 1.3 years, MT group ( n = 10), placebo group ( n = 10) Nocturnal oral MT (5 mg) or placebo ingestion in a double-blind manner Intensive 6-day training-repeated sprint ability test: sprints 6 × 40 m with a 20 s of passive recovery between repetitions Decreased resting OS markers: AOPP, leukocytosis and CK. Decreased post-exercise leukocytosis and markers of cellular damage (CK, ASAT, ALAT), increased GPx and GR activities in MT-treated group vs placebo group Nocturnal MT intake during intensive training decreased OS, leukocytosis, cellular damage, and improved exercise performance LY lymphocytes, WBC white blood cells, NE neutrophils, CRP C-reactive protein, CK creatine kinase, LDH lactate dehydrogenase, ASAT aspartate aminotransferase, MDA malonaldehyde, LDL low-density lipoprotein, maximal oxygen uptake, ALAT alanine aminotransferase, CHO formaldehyde, ORAC oxygen radical absorption capacity, LPO ...…”
Section: Role Of Melatonin Supplementation In Response To Exercise-induced Oxidative Stressmentioning
confidence: 99%
See 3 more Smart Citations
“…Increased serum MT level in footballers and in rowers after a 30-day MT intake. Reduced OS markers: MDA, IL-6, CRP, and low-density lipoproteins Supplementation of MT in professional athletes during intense training may protect against the toxic action of ROS/RNS and inflammation Souissi et al 2018 [ 121 ] Eight healthy moderately trained male students, mean age: 21.8 ± 0.9 years 6 mg MT supplementation or placebo at 09:00 a.m. in a randomized order 50 min before exercise Running at 60% for 45 min on a treadmill, starting at a speed of 8 km/h and increasing by 0.5 km/h after every minute Exercise elevated inflammatory markers: CRP, LDH, ALAT, ASAT in both placebo or MT intake groups MT ingestion before moderate prolonged submaximal exercise showed no anti-inflammatory action Cheikh et al 2020 [ 124 ] Randomized double-blind trial of 14 healthy-trained male athletes, mean age 154 ± 0.3 years 10 mg MT or placebo ingestion (control) after vigorous late-evening exercise (10:00 p.m.) Two-test sessions (separated at least one week) Running-Based Anaerobic Sprint Test at 8:00 p.m. and in the following morning (7:30 a.m.) Reductions of: WBC, NE, LY, CRP, muscle and hepatic damage enzymes (CK, ASAD), LDH, MDA and homocysteine before and after strenuous exercise vs placebo group MT intake after strenuous late-evening exercise diminished transient leukocytosis and protected against lipid peroxidation and muscle damage in teenage athletes Farjallach et al 2019 [ 125 ] 20 soccer players mean age 18.81 ± 1.3 years, MT group ( n = 10), placebo group ( n = 10) Nocturnal oral MT (5 mg) or placebo ingestion in a double-blind manner Intensive 6-day training-repeated sprint ability test: sprints 6 × 40 m with a 20 s of passive recovery between repetitions Decreased resting OS markers: AOPP, leukocytosis and CK. Decreased post-exercise leukocytosis and markers of cellular damage (CK, ASAT, ALAT), increased GPx and GR activities in MT-treated group vs placebo group Nocturnal MT intake during intensive training decreased OS, leukocytosis, cellular damage, and improved exercise performance LY lymphocytes, WBC white blood cells, NE neutrophils, CRP C-reactive protein, CK creatine kinase, LDH lactate dehydrogenase, ASAT aspartate aminotransferase, MDA malonaldehyde, LDL low-density lipoprotein, maximal oxygen uptake, ALAT alanine aminotransferase, CHO formaldehyde, ORAC oxygen radical absorption capacity, LPO ...…”
Section: Role Of Melatonin Supplementation In Response To Exercise-induced Oxidative Stressmentioning
confidence: 99%
“…These observational studies differ from one another mainly in terms of MT timing: taking MT before exercise [ 115 121 ] or before bedtime [ 122 125 ] and its dose, exercise type, intensity, duration and timing, and training level. The most common types of sport training in these studies are cycle ergometer, treadmill exercise or running, in which individuals mainly engaged in maximal or submaximal exercise.…”
Section: Role Of Melatonin Supplementation In Response To Exercise-induced Oxidative Stressmentioning
confidence: 99%
See 2 more Smart Citations
“…Melatonin ( N -acetyl-5-methoxytryptamine), which is the pineal gland’s primary product, regulates circadian rhythm, sleep, and sexual behavior ( Dergaa, Varma, et al, 2021 ; Pandi-Perumal et al, 2008 ; Souissi et al, 2019 ). Melatonin is known to have antioxidant and anti-inflammatory effects ( Escames et al, 2012 ; Kruk et al, 2021 ; Souissi et al, 2018 , 2019 ; Watson et al, 2016 ). Several researchers have looked into the effects of melatonin on endurance exercise ( Alonso et al, 2006 ; Maldonado et al, 2012 ; Souissi et al, 2018 , 2019 ; Veneroso et al, 2009 ).…”
Section: Introductionmentioning
confidence: 99%