Effect of Melatonin on Cerebral Edema in Rats

Görgülü, Adnan; Palaoğlu, Selçuk; İsmailoğlu, Özgür; Tuncel, Mürvet; Tuncer, Meltem; Erbil, Mine; Kılınç, Kamer

doi:10.1097/00006123-200112000-00024

Cited by 27 publications

(6 citation statements)

References 34 publications

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“…In line with previous studies is the finding that Ôexogenously administered melatonin is effective in preventing secondary injuryÕ (11,13,18,40,45). However, it has not been clarified whether the elevated endogenous melatonin alone has a comparable or better neuroprotective effect compared with exogenously administered melatonin.…”

Section: Discussionmentioning

confidence: 58%

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The effects of environmental light-dark changes on experimental mild traumatic brain injury

et al. 2005

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Section: Discussionmentioning

confidence: 58%

“…There are a large number of studies investigating the neuroprotective effects of melatonin (18,20,(40)(41)(42)(43)(44). However, the mechanisms of its physiological actions are not fully understood.…”

Section: Environmental Factors Of Mild Traumatic Brain Injurymentioning

confidence: 99%

The effects of environmental light-dark changes on experimental mild traumatic brain injury

et al. 2005

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“…Murine models of melatonin for brain edema demonstrate decreased edema, infarct area, and blood-brain barrier permeability. 116 Melatonin for closed-head injury decreased contusion volume and significantly increased rate of recovery. 117,118 Potential Therapeutic Indications in PICU…”

Section: Traumatic Brain Injury and Strokementioning

confidence: 99%

Melatonin in Critically Ill Children

Foster

2016

J Pediatr Intensive Care

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Melatonin, while best known for its chronobiologic functions, has multiple effects that may be relevant in critical illness. It has been used for circadian rhythm maintenance, analgesia, and sedation, and has antihypertensive, anti-inflammatory, antioxidant, antiapoptotic, and antiexcitatory effects. This review examines melatonin physiology in health, the current state of knowledge regarding endogenous melatonin production in pediatric critical illness, and the potential uses of exogenous melatonin in this population, including relevant information from basic sciences and other fields of medicine. Pineal melatonin production and secretion appears to be altered in critical illness, though understanding in pediatric critical illness is in early stages, with only 102 children reported in the current literature. Exogenous melatonin may be used for circadian rhythm disturbances and, within the critically ill population, holds promise for diseases involving oxidant stress. There are no studies of exogenous melatonin administration to critically ill children beyond the neonatal period.

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“…A possible reason for this discrepancy with the present study could be the difference in dose and timing of melatonin administration, injury model, and measurement setup. Nonetheless, other studies also showed reduced brain edema 82,83 and its effectiveness in diverse models of experimental traumatic central nervous system. 74,84,85 3.5 Experiment #5: Minocycline Test…”

Section: Introductionmentioning

confidence: 97%

Differential effects of early postinjury treatment with neuroprotective drugs in a mouse model using diffuse reflectance spectroscopy

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Abookasis

2015

Neurophoton

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Abstract. The time required for the arrival of an ambulance crew and administration of first aid is critical to clinical outcome, particularly in the case of head injury victims requiring neuroprotective drugs following a car accident, falls, and assaults. Short response times of the medical team, together with proper treatment, can limit injury severity and even save a life before transportation to the nearest medical center. We present a comparative evaluation of five different neuroprotective drugs frequently used in intensive care and operating units in the early phase following traumatic brain injury (TBI): hypertonic saline (HTS), mannitol, morphine, melatonin, and minocycline. The effectiveness of these drugs in terms of changes in brain tissue morphology (cell organelle size, density, distribution, etc.) and biochemical tissue properties (chromophores' content) was experimentally evaluated through analysis of the spectral reduced scattering and optical absorption coefficient parameters in the near-infrared (NIR) optical range (650 to 1000 nm). Experiments were conducted on anesthetized male mice subjected to a noninvasive closed head weight-drop model of focal TBI (n ¼ 50 and n ¼ 10 control) and monitored using an NIR diffuse reflectance spectroscopy system utilizing independent source-detector separation and location. After 10 min of baseline measurement, focal TBI was induced and measurements were conducted for 20 min. Subsequently, a neuroprotective drug was administrated and measurements were recorded for another 30 min. This work's major findings are threefold: first, minocycline was found to improve hemodynamic outcome at the earliest time postinjury. Second, HTS decreased brain water content and inhibited the increase in intracranial pressure. Third, the efficacy of neuroprotective drugs can be monitored noninvasively with diffuse reflectance spectroscopy. The demonstrated ability to noninvasively detect cerebral physiological properties following early administration of neuroprotective drugs underlines the need for more extensive investigation of the combined use of clinical drugs in larger-scale preclinical experiments to find the most beneficial drug treatment for brain injury patients.

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Effect of Melatonin on Cerebral Edema in Rats

Abstract: Melatonin was found to be neuroprotective in instances of cold-induced brain edema. Thus, melatonin may be a valuable therapeutic agent in the treatment of cerebral edema.

Cited by 27 publications

References 34 publications

The effects of environmental light-dark changes on experimental mild traumatic brain injury

The effects of environmental light-dark changes on experimental mild traumatic brain injury

Melatonin in Critically Ill Children

Differential effects of early postinjury treatment with neuroprotective drugs in a mouse model using diffuse reflectance spectroscopy

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