Effect of Melatonin on Blood Loss After Cesarean Section: A Prospective Randomized Double-Blind Trial

Khezri, Marzieh Beigom; Reihany, Morteza Delkhosh; Ghaleh, Talaat Dabbaghi; Mohammadi, Navid

doi:10.1007/s13224-019-01205-7

Cited by 7 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Melatonin levels peak in pregnant women just before birth, and as such have been posited to signal increased myometrial contractility, like oxytocin 14,15 . In vitro studies show a promising role for melatonin in promoting increased myometrial contractility by synergizing with oxytocin, 16 and a clinical trial of 120 women undergoing cesarean section in India suggested melatonin might reduce blood loss 17 . Its use following vaginal delivery remains unclear; a trial registered in 2015 has not been subsequently updated (Iranian Registry of Clinical Trials [IRCT] 2015050919037N9).…”

Section: Resultsmentioning

confidence: 99%

Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database

McDougall

Goldstein

Tuttle

et al. 2022

Intl J Gynecology & Obste

View full text Add to dashboard Cite

BackgroundA significant barrier to improving prevention and treatment of postpartum hemorrhage (PPH) is a lack of innovative medicines that meet the needs of women and providers, particularly those in low‐and middle‐income countries (LMICs). The Accelerating Innovation for Mothers (AIM) project established a new database of candidate medicines under development for five pregnancy‐related conditions between 2000 and 2021.ObjectiveTo systematically identify and rank candidates for prevention and treatment of PPH.Search StrategyAdis Insight, Pharmaprojects, WHO ICTRP, PubMed, and grant databases were searched to develop the AIM database.Selection CriteriaAIM database was searched for candidates being evaluated for PPH prevention and treatment, regardless of phase.Data Collection and AnalysisCandidates were ranked as high, medium, or low potential based on prespecified criteria. Analysis was primarily descriptive, describing candidates and development potential.Main ResultsOf the 444 unique candidates, only 39 pertained to PPH. One was high potential (heat‐stable/inhaled oxytocin) and three were medium potential (melatonin, vasopressin and dofetilide via nanoparticle delivery).ConclusionThe pipeline for new PPH medicines is concerningly limited, lacking diversity, and showing little evidence of novel technologies. Without significant investment in early‐phase research, it is unlikely that new products will emerge.

show abstract

Section: Resultsmentioning

confidence: 99%

Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database

McDougall

Goldstein

Tuttle

et al. 2022

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…Melatonin has been recognized for its natural hormone secretion by the pineal gland [ 10 ]. Furthermore, it has been found to possess significant anti-inflammatory properties [ 11 ] and has been utilized as a means to reduce blood loss during surgical procedures, particularly during cesarean delivery [ 3 ]. “Postpartum hemorrhage” (PPH) refers to excessive bleeding following childbirth, typically defined as blood loss of 1000 mL or more after a cesarean delivery [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The notion is substantiated by the recent discovery of melatonin MT1 and MT2 receptor transcripts in the human myometrium [ 2 ]. In addition, it has been documented that levels of melatonin experience an increase in the maternal bloodstream, amniotic fluid, and urine of expectant mothers during the course of pregnancy, culminating in a zenith at full term [ 3 ]. Postpartum hemorrhage, or PPH, is a common disease marked by a maternal blood loss of 500 ml or more within 24 hours following delivery.…”

Section: Introductionmentioning

confidence: 99%

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Alkhfaji,

Kahloul,

Askar

et al. 2023

Anesthesiology Research and Practice

View full text Add to dashboard Cite

Background. Postpartum hemorrhage (PPH) is a serious postdelivery condition with a high incidence of morbidity and mortality for women who undergo childbirth with or without a caesarean section. Melatonin has been suggested to increase the contractility of myometrium and reduce the pain score postoperatively, therefore it is believed that the use of melatonin before surgery may decrease blood loss, reduce pain score, and decrease the need for postoperative opioids. Objectives. The main objectives of this study are focused on the investigation of melatonin as a premedication agent to reduce blood loss and decrease pain score postoperatively in patients undergoing cesarean section under spinal anesthesia. Methods. 80 patients were scheduled for spinal anesthesia-based cesarean sections and randomly assigned to two groups, melatonin group (M) 40 patients and placebo group (P) 40 patients to receive either 10 mg of sublingual melatonin or a placebo of 90 minutes preoperatively. Hemoglobin levels were been measured preoperative and 12 hrs. Postoperatively, blood loss volume was calculated by measuring both the weight of used materials before and after the surgery and the volume sucked in the suction bottle after placental delivery. Postoperative visual pain score and analgesic requirements were used to evaluate pain levels. Results. Analyzed collected data showed a significant decrease in blood loss in the melatonin group in comparison with the placebo group as measured by the hemoglobin level. On the other hand, there is a significant decrease in pain score and analgesia requirement with the melatonin group compared to the placebo group. Conclusion. Melatonin is a promising premedication drug that has a significant impact on postpartum hemorrhage by reducing blood loss and pain levels of mothers who have undergone C-sections.

show abstract

“…Current trials are investigating the potential for melatonin to protect the fetus in hostile intrauterine environments such as intra uterine growth restriction [ 103 ]. Research is underway to assess whether melatonin may offer benefit in augmenting induction of labour [ 54 ], preventing blood loss after caesarean section [ 140 ] and post-partum haemorrhage (IRCT2015050919037N9). In humans, melatonin also has anticonvulsant activity [ 141 ], which may be useful in the primary prevention of eclampsia.…”

Section: Melatonin As An Antihypertensivementioning

confidence: 99%

Melatonin for the Management of Preeclampsia: A Review

Langston-Cox

Marshall

et al. 2021

Antioxidants

View full text Add to dashboard Cite

Preeclampsia is a disease specific to pregnancy characterised by new-onset hypertension with maternal organ dysfunction and/or fetal growth restriction. It remains a major cause of maternal and perinatal morbidity and mortality. For sixty years, antihypertensives have been the mainstay of treating preeclampsia and only recently have insights into the pathogenesis of the disease opened new avenues for novel therapies. Melatonin is one such option, an endogenous and safe antioxidant, that may improve the maternal condition in preeclampsia while protecting the fetus from a hostile intrauterine environment. Here we review the evidence for melatonin as a possible adjuvant therapy for preeclampsia, including in vitro evidence supporting a role for melatonin in protecting the human placenta, preclinical models, vascular studies, and clinical studies in hypertension and pregnancy.

show abstract

Effect of Melatonin on Blood Loss After Cesarean Section: A Prospective Randomized Double-Blind Trial

Cited by 7 publications

References 21 publications

Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database

Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Melatonin for the Management of Preeclampsia: A Review

Contact Info

Product

Resources

About