Effect of Melatonin Implants on Reproductive Status of Mares

Guillaume, Daniel; Arnaud, G; Camillo, Francesco; Duchamp, Guy; Palmer, Eric

doi:10.1093/biolreprod/52.monograph_series1.435

Cited by 18 publications

(12 citation statements)

References 7 publications

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“…On May 31st, each female in the MT group received 20 subcutaneous implants of melatonin of 18 mg each (melovin ® , Ceva, Ltd., implant size: 3 mm). The melatonin dose used in this study (1 implant per 28 kg of body weight) was calculated based on a previous study on camels ( 23 ) and studies on mares ( 18 ). Each female received 20 implants (10 implants per ear) on the same day.…”

Section: Methodsmentioning

confidence: 99%

“…Melatonin treatment has been used for manipulation of reproductive seasonality in several species. In ewes ( 8 – 13 ), goats ( 14 – 16 ), red deer ( 17 ), and mares ( 18 ), repeated melatonin injections or its constant release via implants are used during anestrus to induce early onset of reproductive cyclicity with a positive effect on ovarian activity and a suppressive effect of prolactin secretion.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Melatonin Implants during the Non-Breeding Season on the Onset of Ovarian Activity and the Plasma Prolactin in Dromedary Camel

et al. 2018

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To examine a possible control of reproductive seasonality by melatonin, continual-release subcutaneous melatonin implants were inserted 4.5 months before the natural breeding season (October–April) into female camels (Melatonin-treated group). The animals were exposed to an artificial long photoperiod (16L:8D) for 41 days prior to implant placement to facilitate receptivity to the short-day signal that is expected with melatonin implants. The treated and control groups (untreated females) were maintained separately under outdoor natural conditions. Ovarian follicular development was monitored in both groups by transrectal ultrasonography and by plasma estradiol-17β concentrations performed weekly for 8 weeks and then for 14 weeks following implant insertion. Plasma prolactin concentrations were determined at 45 and 15 days before and 0, 14, 28, 56, and 98 days after implant insertion. Plasma melatonin concentration was determined to validate response to the artificial long photoperiod and to verify the pattern of release from the implants. Results showed that the artificial long photoperiod induced a melatonin secretion peak of significantly (P < 0.05) shorter duration (about 2.5 h). Melatonin release from the implants resulted in higher circulating plasma melatonin levels during daytime and nighttime which persisted for more than 12 weeks following implants insertion. Treatment with melatonin implants advanced the onset of follicular growth activity by 3.5 months compared to untreated animals. Plasma estradiol-17β increased gradually from the second week after the beginning of treatment to reach significantly (P < 0.01) higher concentrations (39.2 ± 6.2 to 46.4 ± 4.5 pg/ml) between the third and the fifth week post insertion of melatonin implants. Treatment with melatonin implants also induced a moderate, but significant (P < 0.05) suppressive effect on plasma prolactin concentration on the 28th day. These results demonstrate that photoperiod appears to be involved in dromedary reproductive seasonality. Melatonin implants may be a useful tool to manipulate seasonality and to improve reproductive performance in this species. Administration of subcutaneous melatonin implants during the transition period to the breeding season following an artificial signal of long photoperiod have the potential to advance the breeding season in camels by about 2.5 months.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Melatonin Implants during the Non-Breeding Season on the Onset of Ovarian Activity and the Plasma Prolactin in Dromedary Camel

et al. 2018

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“…In the northern hemisphere temperate regions, although most mares stop cycling between November and January [1] anestrus can begin between August and February [1][2][3]. Factors analyzed to explain seasonality in the mare have been: latitude [4], age [4,5], recent reproductive history (foaled or barren) [5] and nutrition and fat reserves (leptin blood concentration) [6,7] In non-pregnant mares, corpus luteum (CL) progesterone production seems to decline significantly from one cycle to the subsequent at the end of the breeding season [1,3,[8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Corpus Luteum Vascularization and Progesterone Production in Autumn and Winter Cycles of the Mare: Relationship Between Ultrasonographic Characteristics of Corpora Lutea and Plasma Progesterone Concentration in the Last Cycles Before Anestrus

Panzani

Vita

Lainé

et al. 2017

Journal of Equine Veterinary Science

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“…There were no previous reports on the use of melatonin implants in camel, therefore, the dose used for equines (1 implant/28 kg b. wt., s.c.) [15] was used in the present study. The small implants were loaded in a 12 gauze needle and placed subcutaneously under the skin of the neck by pushing the implants with a sterile plunger (Fig.…”

Section: Melatonin Implantsmentioning

confidence: 99%

“…A valid use of the understanding of these physiological rythyms could be phase shifting of reproductive activity in camel by the administration of melatonin implants as has been shown for sheep [10,11], goats [12e14] and mares [15]. Because of a longer gestation period in camels [16] camels conceiving during peak breeding season (March) [8] would parturate at a time when the breeding season is approaching an end.…”

Section: Introductionmentioning

confidence: 99%

Sonographic monitoring of early follicle growth induced by melatonin implants in camels and the subsequent fertility

Dholpuria¹,

Vyas

Purohit

et al. 2012

Journal of Ultrasound

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The present study examined the effect of melatonin implants on follicle growth in dromedary camels two months ahead of their natural breeding season (December to March). Female camels (n Z 6) were treated with melatonin implants at the dose rate of 1 implant per 28 kg body weight sc. Control camels (n Z 6) were administered an SC placebo implant of 8 ml vitamin A. Ovarian ultrasonography was performed at weekly interval upto 7 weeks. Camels were mated with virile stud when a follicle (!10 mm) was visible on either of the ovaries. Blood was collected on day 7, 9, 15, 20, 25 and 30 for assay of plasma progesterone and sonography performed at the same time. Small follicles (2-3 mm) appeared around the periphery of ovaries in 83.3% of camels by day 7 and in 100% camels by day 14. By the end of 7th week an ovulatory size follicle (!1.0 cm) could be observed in 83.3% of treated camels, and these camels were mated with virile studs. In control group, small follicles appeared at the periphery of ovaries only in 66.6% camels but did not progress in growth except in one camel (16.6%) however, ovulating size (!10 mm) follicle was not observed in any camel by the end of 7th week. All treated camels ovulated and one treated camel became pregnant while early embryonic death occurred in one camel. Nonepregnant camels of both groups were mated during the breeding season. All camels of treatment group and 33.33% camels of control group became pregnant by the end of breeding season (April 2010). It was concluded that melatonin implants can augment the follicle growth in lactating camels ahead of the breeding season and pregnancy can occur on mating. Fertility of treated camels during the breeding season is improved.Sommario Nel presente studio viene esaminato l'effetto di impianti di melatonina sulla crescita del follicolo in dromedari -cammelli, nei due mesi precedenti il loro periodo di * Corresponding author.E-mail address: gnpobs@gmail.com (G.N. Purohit). , 25 e 30 giorno, per il dosaggio del progesterone plasmatico e l'ecografia eseguita allo stesso tempo. Follicoli piccoli (2-3 mm) sono apparsi nella periferia delle ovaie nel 83,3% dei cammelli al 7 giorno e nel 100% dei cammelli al 14 giorno. Entro la fine della VII settimana un follicolo ovulatorio di una certa dimensione (! 1,0 cm) è stato osservato nel 83,3% dei cammelli trattati, e questi cammelli sono stati fatti accoppiare. Nel gruppo di controllo, sono apparsi piccoli follicoli alla periferia delle ovaie solo nel 66,6% dei cammelli, ma senza progresso nella crescita, fatta eccezione per un cammello (16,6%), tuttavia, la dimensione di un follicolo ovulatorio (! 10 mm) non è stata osservata in nessun cammello, entro la fine della VII settimana. Tutti i cammelli trattati hanno avuto un'ovulazione e un cammello è rimasto incinta, mentre è avvenuta la morte precoce di un embrione in un altro cammello. I cammelli non gravidi di entrambi i gruppi sono stati accoppiati durante la stagione riproduttiva. Tutti i cammelli del gruppo di trattamento e 33,33% dei cammell...

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Effect of Melatonin Implants on Reproductive Status of Mares

Cited by 18 publications

References 7 publications

Effect of Melatonin Implants during the Non-Breeding Season on the Onset of Ovarian Activity and the Plasma Prolactin in Dromedary Camel

Effect of Melatonin Implants during the Non-Breeding Season on the Onset of Ovarian Activity and the Plasma Prolactin in Dromedary Camel

Corpus Luteum Vascularization and Progesterone Production in Autumn and Winter Cycles of the Mare: Relationship Between Ultrasonographic Characteristics of Corpora Lutea and Plasma Progesterone Concentration in the Last Cycles Before Anestrus

Sonographic monitoring of early follicle growth induced by melatonin implants in camels and the subsequent fertility

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