Effect of Medium Chain Triglyceride on Lipogenesis and Body Fat in the Rat

Lavau, M; Hashim, Sami A.

doi:10.1093/jn/108.4.613

Cited by 125 publications

(67 citation statements)

References 22 publications

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“…This finding is in contrast to the well-established reduction in insulin-stimulated fatty acid synthesis in the adipocytes of rats fed an HF diet, even though the fatty acid composition is mainly medium chain triglycerides (22), which predominate in the coconut oil diet used here and in a previous study (2). It would therefore be of interest to assess the effect of HF diets composed of long-chain fatty acids in AFABP-KO mice.…”

Section: E S I G N a N D M E T H O D Scontrasting

confidence: 82%

Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein.

et al. 2000

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Mice null for adipocyte fatty acid binding protein ( A FABP) compensate by increasing expression of keratinocyte fatty acid binding protein (KFABP) (Hotamisligil et al. S c i e n c e 274:1377-1379, 1996). In the present s t u d y, AFABP knockout (KO) and wild-type (WT) mice became equally obese on a high-fat diet, as judged by fat pad weights, adipocyte size, and body composition analysis. High-fat feeding led to moderate insulin resistance in both WT and AFABP knockout mice, as indicated by an ~2-fold increase in plasma insulin. H o w e v e r, in the high fat-fed mice, plasma glucose levels were ~15% lower in the AFABP-KO mice. Adipocytes isolated from AFABP-KO and WT mice fed high-or low-fat diets exhibited similar rates of basal and norepinephrine-stimulated lipolysis and insulinstimulated rates of glucose conversion to fatty acids and glyceride-glycerol. However, basal glucose conversion to fatty acids was higher in adipocytes of AFA B P -KO mice. Adipocyte tumor necrosis factor-r e l e a s e was similarly increased by high-fat diet-induced obesity in both WT and AFABP-KO mice. As assessed by We s tern blot analysis, the level of KFABP protein in A FABP-KOs was ~40% of the level of AFABP in WT controls. The binding affinities of KFABP for longchain fatty acids were 2-to 4-fold higher than those of A FA B P, but the relative affinities for different fatty acids were similar. As for AFA B P, the rate of fatty acid transfer from KFABP to model phospholipid vesicles was increased with acceptor membrane concentration and by inclusion of acidic phospholipids, indicating a similar mechanism of transfer. We conclude KFABP can functionally compensate for the absence of AFA B P, resulting in no major alterations in adipocyte metabolism or fat accumulation in response to short-term feeding of high-fat diets that result in moderate hyperinsulinemia. D i a b e t e s 4 9 :9 0 4-911, 2000

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Section: E S I G N a N D M E T H O D Scontrasting

confidence: 82%

Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein.

et al. 2000

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“…10%-20%) did not affect the weight gain or feed utilization efficiency of young pigs (Allee et al, 1972;Newport et al, 1979) or rats (Travis et al, 1979). Furthermore, Lavau and Hashim (1978) and Baba et al (1982) reported that dietary supplementation with 20%-35% MCT decreased the weight gain of rats. These results indicate that supplementation with a lower level of MCT in diets may improve the growth performance of animals.…”

Section: Discussionmentioning

confidence: 99%

“…It was found that dietary MCT increased body protein deposition (Chiang et al, 1990a) and decreased body fat deposition (Lavau and Hashim, 1978;Newport et al, 1979;Travis et al, 1979;Baba et al, 1982) in animals. The decreasing effect of MCT on body fat deposition may be due to the lower energy content in MCT-containing diets and a reflection of the increasing effect of MCT on protein deposition.…”

Section: Discussionmentioning

confidence: 99%

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The effects of dietary medium-chain triacylglycerols on growth performance and intestinal microflora in young pigs

Lai¹,

Yen²,

Lin³

et al. 2014

J. Anim. Feed Sci.

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“…Several studies in both animals [5,8,12,17] and humans [26,31,32] suggest that medium-chain triglycerides (MCT) enhance satiety and decrease food intake more than long-chain triglycerides (LCT). The reason for this difference is unknown, but the differences in post-absorptive handling of MCT and LCT may be important.…”

Section: Introductionmentioning

confidence: 99%

Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats

Sousa

Benthem

Arsenijevic

et al. 2006

Physiology & Behavior

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. Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats. Physiology and Behavior, 89(3), 329-334. https://doi.org/10.1016/j.physbeh.2006.06.020 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractIn several human and animal studies, medium-chain triglycerides decreased food intake more than did long-chain triglycerides. It is possible that faster uptake and metabolism of medium-chain fatty acids in the liver is responsible for this difference. To test this hypothesis we compared the feeding effects of hepatic portal vein (HPV) infusion of the medium-chain fatty acid caprylic acid (CA) with those of the long-chain fatty acid oleic acid (OA). Contrary to our expectation, six-h HPV infusion of 14 μg/min (50 nmol/min) OA robustly inhibited feeding, whereas infusion of 22 or 220 μg/min (150 and 1500 nmol/min) CA failed to have any effect on feeding. Only a much larger dose of CA, 1100 μg/min (7500 nmol/ min) inhibited feeding similarly to 14 μg/min OA. The increased feeding-inhibitory potency of OA did not appear to be due to differences in stimulation of hepatic fatty acid oxidation because equimolar (50 nmol/min) doses of OA (14 μg/min) and CA (7 μg/min) did not differentially affect post-infusion levels of β-hydroxybutyrate. Stress, inflammation, acute hepatotoxicity or oxidative stress also do not appear to account for the increased feeding-inhibitory potency of HPV OA because plasma concentrations of the stress hormones corticosterone and epinephrine, the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α, the liver enzymes γ-glutamyl transferase and alanine aminotransferase and as well as hepatic levels of malondialdehyde and glutathione were all similar after HPV infusion of saline or of 50 nmol/min OA or CA.

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Effect of Medium Chain Triglyceride on Lipogenesis and Body Fat in the Rat

Cited by 125 publications

References 22 publications

Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein.

Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein.

The effects of dietary medium-chain triacylglycerols on growth performance and intestinal microflora in young pigs

Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats

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