“…Observational studies confirmed that inhaled prostacyclins, such as aerosolized PG I2, and PG E1, determined an improvement in oxygenation and lung compliance, and a reduction in ventilator dependency but no difference in mortality [84,85]. Mechanical ventilation in the prone position has also been applied in case of serious impairment of gas exchange associated with ARDS [86]. It may result in an improvement in oxygenation due to various possible mechanisms: recruitment of dependent lung units, redistribution of blood flow to the more unaffected lung regions, reducing ventilation perfusion mismatch, and facilitation of respiratory secretion clearance [87].…”