Effect of Matrix Stiffness and Hepatocyte Growth Factor on Small Cell Lung Cancer Cells in Decellularized Extracellular Matrix‐Based Hydrogels
Yoobin Han,
Chang Seok Ki
Abstract:Small cell lung cancer (SCLC) is one of lethal cancers resulting in very low 5‐year‐survival rate. Although its clinical treatment largely relies on chemotherapy, SCLC cell physiology in three‐dimensional matrix has been less explored. In this work, the tumor microenvironment is reconstructed with decellularized porcine pulmonary extracellular matrix (dECM) with hyaluronic acid. To modulate matrix stiffness, the methacrylate groups are introduced into both dECM and hyaluronic acid, followed by photocrosslinkin… Show more
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