Effect of matrix saturation magnetization on particle capture in high gradient magnetic separation

Wang, Yuhua; Xue, Zixing; Zheng, Xiayu; Lu, Dongfang; Li, Si; Li, Xudong

doi:10.1016/j.mineng.2019.105866

Cited by 21 publications

(2 citation statements)

References 28 publications

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“…[167] Co-precipitation, either by in situ (one-step with simultaneous formation and impregnation of magnetic NPs in AC framework [168,169] ) or ex-situ (two-step involving the synthesis of magnetic NPs followed by their dispersion with AC [170,171] ), are the most conventional MAC synthesis owing to their simplicity, productivity, and cost-effectiveness. [167] Saturation magnetization (M s ) is a very important parameter when considering magnetic separation of magnetized PAC, [172] and M s values are usually reported to support magnet responsiveness. For example, M s of magnetite NPs is generally between 60-80 emu g −1 (depending on the phase purity obtained under the specific synthesis method).…”

Section: Magnet-responsive Adsorbentsmentioning

confidence: 99%

Smart Adsorbents for Aquatic Environmental Remediation

Zare‬

Mudhoo

Khan

et al. 2021

Small

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Section: Magnet-responsive Adsorbentsmentioning

confidence: 99%

Smart Adsorbents for Aquatic Environmental Remediation

Zare‬

Mudhoo

Khan

et al. 2021

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“…In high‐gradient magnetic separation, the magnetic field distribution and thus, the gradient of the magnetic field is significantly influenced by the material of the filter matrix as well as its structure, arrangement, and size [32–35]. Since the matrix normally comes into contact with the suspension, it should have chemical resistance and corrosion resistance, as well as meeting leachables and extractables (L&E) criteria in biopharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Development of a 3D‐printed single‐use separation chamber for use in mRNA‐based vaccine production with magnetic microparticles

Wommer

Meiers

Kockler

et al. 2021

Engineering in Life Sciences

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Laboratory protocols using magnetic beads have gained importance in the purification of mRNA for vaccines. Here, the produced mRNA hybridizes specifically to oligo(dT)‐functionalized magnetic beads after cell lysis. The mRNA‐loaded magnetic beads can be selectively separated using a magnet. Subsequently, impurities are removed by washing steps and the mRNA is eluted. Magnetic separation is utilized in each step, using different buffers such as the lysis/binding buffer. To reduce the time required for purification of larger amounts of mRNA vaccine for clinical trials, high‐gradient magnetic separation (HGMS) is suitable. Thereby, magnetic beads are selectively retained in a flow‐through separation chamber. To meet the requirements of biopharmaceutical production, a disposable HGMS separation chamber with a certified material (United States Pharmacopeia Class VI) was developed which can be manufactured using 3D printing. Due to the special design, the filter matrix itself is not in contact with the product. The separation chamber was tested with suspensions of oligo(dT)‐functionalized Dynabeads MyOne loaded with synthetic mRNA. At a concentration of cB = 1.6–2.1 g·L–1 in lysis/binding buffer, these 1 μm magnetic particles are retained to more than 99.39% at volumetric flows of up to 150 mL·min–1 with the developed SU‐HGMS separation chamber. When using the separation chamber with volumetric flow rates below 50 mL·min–1, the retained particle mass is even more than 99.99%.

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