Effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum

Abstract

Maternal vitamin E supplementation increases the supply of the vitamin to the infant by providing more than twice the Recommended Daily Intake.

Maternal Circulating Vitamin Status and Colostrum Vitamin Composition in Healthy Lactating Women—A Systematic Approach

“…No additional articles were obtained from the reference lists of the included articles. Hence, 11 articles were considered in the present review, of which six were cross-sectional studies [ 41 , 42 , 43 , 44 , 45 , 47 ], four described randomised controlled clinical trials [ 36 , 38 , 39 , 40 ], and one was a quasi-experimental intervention study conducted in a convenience sample without control group [ 48 ]. Coinciding collection of colostrum and blood were baseline measurements for all randomised controlled trials and the quasi-experimental study, thus data on lost to follow up were not extracted for the current review.…”

“…In eight studies, colostrum was obtained by manual expression [ 36 , 39 , 41 , 42 , 43 , 44 , 47 , 48 ]; in two studies, a manual breast pump was used [ 45 , 40 ]; and in one publication, no information on expression method was given [ 38 ]. Blood sample collection was done by venipuncture in five studies [ 36 , 39 , 43 , 44 , 48 ]; one article stated blood samples concerned venous blood [ 40 ], and in five publications no information on blood collection method was given [ 38 , 41 , 42 , 45 , 47 ]. In the majority of the studies, colostrum and blood samples were obtained at one time point between the first and fifth postpartum day, except for one study collecting colostrum samples over 1–3 days postpartum in order to establish a colostrum pool [ 42 ], and for three publications, the postpartum day was not mentioned [ 36 , 43 , 48 ].…”

“…Blood sample collection was done by venipuncture in five studies [ 36 , 39 , 43 , 44 , 48 ]; one article stated blood samples concerned venous blood [ 40 ], and in five publications no information on blood collection method was given [ 38 , 41 , 42 , 45 , 47 ]. In the majority of the studies, colostrum and blood samples were obtained at one time point between the first and fifth postpartum day, except for one study collecting colostrum samples over 1–3 days postpartum in order to establish a colostrum pool [ 42 ], and for three publications, the postpartum day was not mentioned [ 36 , 43 , 48 ]. Nine articles indicated that the samples were stored at a temperature ranging between −18 °C and −70 °C after serum preparation [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 48 ].…”

“…Nine articles indicated that the samples were stored at a temperature ranging between −18 °C and −70 °C after serum preparation [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 48 ]. In eight studies, samples were collected after an overnight fast [ 36 , 38 , 39 , 41 , 42 , 43 , 44 , 48 ]; whereas in the remaining three studies, the prandial state of participants was not specified [ 40 , 45 , 47 ]. Vitamin content of maternal serum/plasma and colostrum was analysed through high-performance liquid chromatography-UV (HPLC-UV) in eight studies [ 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ], one combined HPLC-UV and a protein-binding assay [ 45 ], and one study used UV spectrophotometry [ 47 ].…”

α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions

“…Teratogenic potential of vitamin E is reportedly minor in both rodents and humans [44,53,58]; however, high maternal vitamin E intake was shown to correlate with an increased risk of congenital heart defects in offspring [59]. Moreover, concerns for the safety of massive α-T intake in pregnancy have to be extended to lactation, when α-T transfer is more efficient and more readily increased via maternal intake [60], as recently confirmed in humans [61,62,63]. …”