Effect of maternal pregestational diabetes mellitus on congenital heart diseases

Chen, Zhiyan; Mao, Shuangfa; Guo, Linghong; Qin, Jianguang; Yang, L.; Yin, Liu

doi:10.1007/s12519-022-00582-w

Cited by 5 publications

(7 citation statements)

References 104 publications

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“…Our results indicate a significant association between pre-gestational diabetes and the occurrence of CHD in newborns. This finding aligns with previous studies highlighting the role of maternal diabetes as a risk factor for the development of CHD [ 9 – 11 ]. The biochemical mechanistic link between maternal diabetes and CHD development remains complex and multifaceted.…”

Section: Discussionsupporting

confidence: 93%

“…Maternal obesity is linked to various cardiac defects, including septal defects, aortic arch defects, persistent ductus arteriosus, conotruncal defects, and ventricular outflow defects [ 8 ]. Moreover, high maternal BMI predisposes women to develop other health risk factors, such as an elevated risk of developing Type 2 diabetes and gestational diabetes [ 10 , 11 ]. Diabetes mellitus is characterized by insufficient insulin production (Type 1) or abnormal insulin response, leading to hyperglycemia (Type 2).…”

Section: Introductionmentioning

confidence: 99%

“…Diabetes mellitus is characterized by insufficient insulin production (Type 1) or abnormal insulin response, leading to hyperglycemia (Type 2). Studies have also indicated a potential correlation between pre-gestational diabetes and the risk of congenital health anomalies like CHD [ 9 – 11 ]. In addition, diseases during pregnancy may influence the development and viability of the fetus [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

Delgado,

Gaytan,

Perez

et al. 2024

CHD

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Background: Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States, there is a compelling need to investigate the intricate interplay among BMI, pregestational, and gestational maternal diabetes, and their potential impact on the occurrence of congenital heart defects (CHD) during neonatal development. Methods: Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico, we conducted a focused analysis on neonates diagnosed with CHD between 2016 and 2020. Our assessment encompassed a range of variables, including maternal age, gestational age, BMI, pregestational diabetes, gestational diabetes, hypertension, history of abortion, and presence of preeclampsia. Results: A cohort of 673 patients was included in our study. The average maternal age was 26 years, within a range of 22 to 32 years. The mean gestational age measured 39 weeks, with a median span of 38 to 39 weeks. Of the 673 patients, 274 (41%) mothers gave birth to neonates diagnosed with CHD. Within this group, 22 cases were linked to pre-gestational diabetes, while 202 were not; 20 instances were associated with gestational diabetes, compared to 200 without; and 148 cases exhibited an overweight or obese BMI, whereas 126 displayed a normal BMI. Conclusion: We identified a statistically significant correlation between pre-gestational diabetes mellitus and the occurrence of CHD. However, our analysis did not show a statistically significant association between maternal BMI and the likelihood of CHD. These results may aid in developing effective strategies to prevent and manage CHD in neonates.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

Delgado,

Gaytan,

Perez

et al. 2024

CHD

View full text Add to dashboard Cite

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“…Congenital heart diseases (CHDs) are among the most life-threatening factors for the pediatric population worldwide. Approximately 0.8% to 1.2% of live births are affected by CHDs, among which Right Ventricle Outflow Tract Obstruction (RVOTO) contributes to 15% of total congenital heart diseases [ 1 , 2 , 3 , 4 , 5 ]. With the remarkable progress in surgical approaches, the percentage of CHD patients who reach adulthood is increasing over time [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Tergitol Based Decellularization Protocol Improves the Prerequisites for Pulmonary Xenografts: Characterization and Biocompatibility Assessment

et al. 2023

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Right ventricle outflow tract obstruction (RVOTO) is a congenital pathological condition that contributes to about 15% of congenital heart diseases. In most cases, the replacement of the right ventricle outflow in pediatric age requires subsequent pulmonary valve replacement in adulthood. The aim of this study was to investigate the extracellular matrix scaffold obtained by decellularization of the porcine pulmonary valve using a new detergent (Tergitol) instead of Triton X-100. The decellularized scaffold was evaluated for the integrity of its extracellular matrix (ECM) structure by testing for its biochemical and mechanical properties, and the cytotoxicity/cytocompatibility of decellularized tissue was assessed using bone marrow-derived mesenchymal stem cells. We concluded that Tergitol could remove the nuclear material efficiently while preserving the structural proteins of the matrix, but without an efficient removal of the alpha-gal antigenic epitope. Therefore, Tergitol can be used as an alternative detergent to replace the Triton X-100.

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“…83 Another study also demonstrated that maternal gestational diabetes mellitus increases the risk of AD in offspring within 3 years of birth (adjusted hazard ratio = 1.44, p = 0.038). 84 A unit increase in oral glucose tolerance test after 2 h glucose in mothers increases the risk of allergic diseases in offspring by 11% (95% CI: 2%-21%). 84 Interestingly, maternal gestational diabetes does not increase the risk of AD in TA B L E 1 Interplay between atopic dermatitis and diabetes mellitus.…”

Section: Diabetes Mellitus Increases the Risk Of Admentioning

confidence: 99%

Interplay between diabetes mellitus and atopic dermatitis

Lei,

Zhang,

Zhu

et al. 2024

Experimental Dermatology

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Inflammatory dermatoses such as atopic dermatitis (AD) have long been linked to the pathogenesis of diabetes mellitus. Indeed, numerous studies show an increased risk of diabetes mellitus in individuals with AD although lower prevalence of diabetes mellitus is also observed in few studies. Though the underlying mechanisms accounting for the reciprocal influence between these two conditions are still unclear, the complex interplay between diabetes mellitus and AD is attributable, in part, to genetic and environmental factors, cytokines, epidermal dysfunction, as well as drugs used for the treatment of AD. Proper management of one condition can mitigate the other condition. In this review, we summarize the evidence of the interaction between diabetes mellitus and AD, and discuss the possible underlying mechanisms by which these two conditions influence each other.

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Effect of maternal pregestational diabetes mellitus on congenital heart diseases

Cited by 5 publications

References 104 publications

Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

Tergitol Based Decellularization Protocol Improves the Prerequisites for Pulmonary Xenografts: Characterization and Biocompatibility Assessment

Interplay between diabetes mellitus and atopic dermatitis

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