Effect of maternal organic selenium supplementation during pregnancy on sow reproductive performance and long-term effect on their progeny

Mou, Daolin; Ding, Dajiang; Li, Shuang; Yan, Hui; Qin, Binting; Li, Zhen; Zhao, Lianpeng; Che, Lianqiang; Fang, Zhengfeng; Xu, Shengyu; Lin, Yan; Li, Jian; Huang, Chao; Zou, Yuanfeng; Li, Lixia; Briens, Mickaël; Wu, De

doi:10.1093/jas/skaa366

Cited by 22 publications

(33 citation statements)

References 64 publications

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“…Studies have shown that HMSeBA to be more bioavailable than sodium selenite or selenium yeast in poultry, growing pigs and weaned pigs [12][13][14][15]. Our lab also found HMSeBA supplementation during sow pregnancy increased the number of total born piglets, decreased the piglet birth interval, improved concentrations of total selenium, and also improved activity of antioxidant enzymes compare with the control and sodium selenite treatment [16]. However, the available data concerning HMSeBA action on the gilts' reproduction and function on the granulose cells remain insufficient.…”

Section: Introductionsupporting

confidence: 54%

“…We found that the age and weight of puberty in DLY gilts were higher than those in LY gilts (220-250d vs. 190-210d, 120-140kg vs. 105-120kg, Zhou et al, 2010) [22]. In the current study, the gilts were applied the same treatments with their maternal generation during gestation [16]. Dietary supplementation with HMSeBA increased the average daily body weight gain (ADG) and decreased the ratio of feed: gain during day 120 to 176 in gilts.…”

Section: Discussionmentioning

confidence: 44%

“…Studies of selenium (Se) status indicate that Se is necessary for fertility [5][6][7]9]. HMSeBA as an organic Se source has been studied in poultry, weaned pigs, growing pigs and sows [12,15,16,19]. This is the first study focused on the effect of dietary supplementation with HMSeBA on the follicle development in gilts.…”

Section: Discussionmentioning

confidence: 99%

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2-Hydroxy-4-Methylselenobutanoic Acid (HMSeBA) Promote Follicle Development By Antioxidant Pathway in Gilts

Dong

Chen

Liu

et al. 2021

Preprint

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Background Dietary 2-hydroxy-4-methylselenobutanoic acid (HMSeBA) supplementation can exert antioxidant effects in poultry, pigs and weaned pigs. However, it is unknown whether HMSeBA could improve the development of follicle by anti-oxidize effects in gilt. This study was conducted to evaluate the effects of dietary HMSeBA supplementation on the follicle development in gilt. A total of 36 gilts were randomly fed the control diet (CON, negative control), Na2SeO3 diet containing 0.3 mg Se/kg (positive control) or the HMSeBA diet containing 0.3 mg Se/kg from weaning to the 19th day after the second estrus. In another study, the effect of HMSeBA on the cells viability, proliferation, release of 17βestradiol (E2 ) and antioxidant capacity were investigated in the mouse ovarian granulosa cells in vitro. Results Results showed that HMSeBA group increased the average daily body weight gain (ADG) and decreased the ratio of feed: gain during day 120 to 176 in gilts ( P < 0.05). The selenium (HMSeBA and Na 2 SeO 3 ) increased the weight of uterine at the third estrus. There was no effect of HMSeBA on the number of large follicles (diameter >5mm), but HMSeBA decreased the gene expression of growth differentiation factor-9 ( GDF-9 ) and bone morphogenetic protein-15 ( BMP-15 ) in cumulus-oocyte complexes (COCs). HMSeBA group increased the total selenium content in serum ( P < 0.05) and liver ( P < 0.01) and tended to increase the total selenium content in ovary ( P = 0.08). HMSeBA group decreased the malondialdehyde (MDA) concentration in the serum, liver and ovary ( P < 0.05), increased the total antioxidant capacity (T-AOC) in the liver, thioredoxin reductase (TrxR) in the ovary ( P < 0.05) and increased the activity of GPx in the serum, liver and ovary ( P < 0.05). Na 2 SeO 3 supplementation decreased MDA and increased the T-AOC in liver, increased the T-SOD and TrxR in the ovary compared with control. At the transcription level, HMSeBA group increased the glutathione peroxidase 2 ( GPx2 ) and TrxR1 ( P < 0.05) expression in the liver, and increased the GPx1 expression ( P < 0.05) in the ovary of gilts compared with Na2SeO3 treatment. Besides, HMSeBA group increased the expressions of superoxide dismutase 1 ( SOD1 ) and Thioredoxin l ( Trx1 ) in the liver. In vitro experiment, HMSeBA improved granulosa cells’ proliferation and E2 secretion ( P < 0.05). HMSeBA and Na 2 SeO 3 both increased the T-AOC and decreased MDA in granulosa cells in vitro. Meanwhile, HMSeBA increased T-SOD, GPx, glutathione reductase (GR) and TrxR activity in granulosa cells in vitro. In addition, HMSeBA up-regulated SOD2 and GPx1 gene expression in the granulosa cells in vitro.Conclusion These results demonstrate directly, HMSeBA was more conducive to absorption and storage of selenium in the liver and ovary in gilt, and beneficial to exert the effect of HMSeBA on the antioxidant function in the liver and ovary of gilt. Moreover, HMSeBA has stronger antioxidant capacity in granular cells in vitro , which is more conducive to promoting follicle development. Therefore, the new type of organic selenium, HMSeBA, could be potentially useful for the control of reproductive processes in gilt.

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Section: Introductionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 44%

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2-Hydroxy-4-Methylselenobutanoic Acid (HMSeBA) Promote Follicle Development By Antioxidant Pathway in Gilts

Dong

Chen

Liu

et al. 2021

Preprint

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“…In total, 12, 11 and 10 studies included data on selenium content in colostrum (WMD = 0.063, 95% CI [0.041, 0.085], P < 0.01, I 2 = 89.2%), selenium content in milk (WMD = 0.035, 95% CI [0.019, 0.052], P < 0.01, I 2 = 99.3%) and selenium content in sow serum (WMD = 0.010, 95% CI [0.003, 0.017], P < 0.01, I 2 = 90%), respectively. There were 14 studies that mentioned the effect of Yue, 2012 Yoon and McMillan, 2006Xu, 2017Wang and Yang, 2013Szuba-Trznadel et al, 2017Svoboda et al, 2009Svoboda et al, 2008Quesent et al, 2008Mou et al, 2020bMou et al, 2020aMahan and Kim, 1996Mahan and Peter, 2004Mahan, 2000Ma et al, 2014Lin et al, 2013Li, 2009Jia, 2012Falk et al, 2020 organic and mineral selenium source on selenium content in piglet serum (WMD = 0.033, 95% CI [0.014, 0.052], P < 0.01, I 2 = 99.5%), and eight studies measured the GSH-Px activity in piglet serum (WMD = 0.044, 95% CI [0.004, 0.085], P < 0.05, I 2 = 87.5%). Figure 6 shows a forest plot summarizing the above data.…”

Section: Heterogeneity Test and Statistical Analysismentioning

confidence: 99%

Effects of different selenium sources on sow reproductive performance and piglet development: a meta-analysis

Zhou¹,

Wu²,

Liu³

et al. 2021

J. Anim. Feed Sci.

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Selenium is an essential trace element for pig growth; generally, inorganic or organic selenium is used for dietary selenium supplementation. Newborn piglets obtain all nutrients from the sow; thus, the sow absorption rate of different selenium sources significantly affects sow reproductive performance and piglet development. Therefore, a meta-analysis was performed to provide insights into whether organic selenium is better than mineral selenium for improving sow reproductive performance and piglet development. The present study investigated the effects of different selenium sources in sow feed using articles published between June 1, 1980, and December 31, 2020, from four databases. In the meta-analysis, 19 articles (347 sows) from seven countries were included. It was shown that feeding organic selenium to sows during pregnancy significantly increased newborn piglet weight (P < 0.05), piglet weight at weaning (P < 0.05), litter weight at weaning (P < 0.01), selenium content in sow colostrum (P < 0.01), milk (P < 0.01) and serum (P < 0.01); and selenium content (P < 0.01) and glutathione peroxidase activity (P < 0.05) in piglet serum. However, it had no effect on the number of liveborn piglets and litter weight at birth. Owing to study heterogeneity (I 2 > 50%), we hypothesized that the sow breed or weaning age were the influencing factors. Publication bias and sensitivity analyses indicate that the present results are robust. Further research is needed to better understand how different selenium sources affect sow reproduction and piglet development.

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“…The effectiveness of this new organic selenium source in poultry, growing pigs, and sows has been reported (Jlali et al, 2013;Chao et al, 2019). Adding HMSEBA in the diet of sows can improve the antioxidant capacity of sows and their offspring (Mou et al, 2020a). However, the effect of HMSeBA on gilts has not been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Organic Selenium Increased Gilts Antioxidant Capacity, Immune Function, and Changed Intestinal Microbiota

Dong

Chen

et al. 2021

Front. Microbiol.

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Selenium is an indispensable essential micronutrient for humans and animals, and it can affect biological functions by combining into selenoproteins. The purpose of this study was to investigate the effects of 2-hydroxy-4-methylselenobutanoic acid (HMSeBA) on the antioxidant performance, immune function, and intestinal microbiota composition of gilts. From weaning to the 19th day after the second estrus, 36 gilts (Duroc × Landrace × Yorkshire) were assigned to three treatments: control group, sodium selenite group (0.3 mg Se/kg Na2SeO3), and HMSeBA group (0.3 mg Se/kg HMSeBA). Dietary supplementation with HMSeBA improved the gilts tissue selenium content (except in the thymus) and selenoprotein P (SelP1) concentration when compared to the Na2SeO3 or control group. Compared with the control group, the antioxidant enzyme activity in the tissues from gilts in the HMSeBA group was increased, and the concentration of malondialdehyde in the colon had a decreasing trend (p = 0.07). Gilts in the HMSeBA supplemented group had upregulated gene expression of GPX2, GPX4, and SelX in spleen tissue, TrxR1 in thymus; GPX1 and SelX in duodenum, GPX3 and SEPHS2 in jejunum, and GPX1 in the ileum tissues (p < 0.05). In addition, compared with the control group, the expression of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1) in the liver, spleen, thymus, duodenum, ileum, and jejunum of gilts in the HMSeBA group were downregulated (p < 0.05), while the expression of interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) in the liver, thymus, jejunum, and ileum were upregulated (p < 0.05). Compared with the control group and the Na2SeO3 group, HMSeBA had increased concentration of serum cytokines interleukin-2 (IL-2) and immunoglobulin G (IgG; p < 0.05), increased concentration of intestinal immunoglobulin A (sIgA; p < 0.05), and decreased concentration of serum IL-6 (p < 0.05). Dietary supplementation with HMSeBA also increased the abundance of intestinal bacteria (Ruminococcaceae and Phascolarctobacterium; p < 0.05) and selectively inhibited the abundance of some bacteria (Parabacteroides and Prevotellaceae; p < 0.05). In short, HMSeBA improves the antioxidant performance and immune function of gilts, and changed the structure of the intestinal microflora. And this study provided data support for the application of HMSeBA in gilt and even pig production.

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Effect of maternal organic selenium supplementation during pregnancy on sow reproductive performance and long-term effect on their progeny

Cited by 22 publications

References 64 publications

2-Hydroxy-4-Methylselenobutanoic Acid (HMSeBA) Promote Follicle Development By Antioxidant Pathway in Gilts

2-Hydroxy-4-Methylselenobutanoic Acid (HMSeBA) Promote Follicle Development By Antioxidant Pathway in Gilts

Effects of different selenium sources on sow reproductive performance and piglet development: a meta-analysis

Organic Selenium Increased Gilts Antioxidant Capacity, Immune Function, and Changed Intestinal Microbiota

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