Effect of Maternal Obesity on Fetal Growth and Expression of Placental Fatty Acid Transporters

Ye, Kui; Li, Li; Zhang, Dan; Li, Yang; Wang, Hai Qing; Lai, Han; Hu, Chuan Lai

doi:10.4274/jcrpe.4510

Cited by 6 publications

(4 citation statements)

References 40 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rats fed a 45% fat diet generally had offspring with reduced birth and/or fetal weights [29, 30, 32, 113–115], although the only study that used a nutrient-matched control diet showed an increase in birthweight [55]. In contrast, feeding rats a 57–60% fat diet generally had no effect on birth or fetal weight [45, 47–51, 117], although one study, which also provided fructose in the water of dams on the HFD, found a reduction in birthweight [116].…”

Section: Resultsmentioning

confidence: 99%

“…In mice, this approach increased fetal weight in two studies [97, 98], had no effect in another [132], and decreased fetal weight in a fourth [90]. Ye et al [115] fed rats a HFD and selected those with the greatest weight gain (susceptible to diet-induced obesity) and those with the lowest weight gain (resistant to diet-induced obesity) and found that fetal weight was reduced in susceptible dams but not in resistant dams.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent meta-analysis, maternal HFD tended to increase birthweight in mice and decrease birthweight in rats, although species and strain contributed relatively little to between-study variability in the metabolic effects of maternal HFD [27]. Strains of mice differ in their susceptibility to the metabolic effects of HFD [144], but it is not necessarily the case that more susceptible strains are better models; more resistant strains may offer the opportunity to study differences between obesity-susceptible and obesity-resistant individuals (e.g., [115]). Glucose metabolism even differs between substrains of C57BL/6 [145], which underscores the importance of reporting the substrain, e.g., C57BL/6 J vs. C57BL/6 N.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of high-fat diets on fetal growth in rodents: a systematic review

Christians

Lennie

Wild

et al. 2019

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Background Maternal nutrition during pregnancy has life-long consequences for offspring. However, the effects of maternal overnutrition and/ or obesity on fetal growth remain poorly understood, e.g., it is not clear why birthweight is increased in some obese pregnancies but not in others. Maternal obesity is frequently studied using rodents on high-fat diets, but effects on fetal growth are inconsistent. The purpose of this review is to identify factors that contribute to reduced or increased fetal growth in rodent models of maternal overnutrition. Methods We searched Web of Science and screened 2173 abstracts and 328 full texts for studies that fed mice or rats diets providing ~ 45% or ~ 60% calories from fat for 3 weeks or more prior to pregnancy. We identified 36 papers matching the search criteria that reported birthweight or fetal weight. Results Studies that fed 45% fat diets to mice or 60% fat diets to rats generally did not show effects on fetal growth. Feeding a 45% fat diet to rats generally reduced birth and fetal weight. Feeding mice a 60% fat diet for 4–9 weeks prior to pregnancy tended to increase in fetal growth, whereas feeding this diet for a longer period tended to reduce fetal growth. Conclusions The high-fat diets used most often with rodents do not closely match Western diets and frequently reduce fetal growth, which is not a typical feature of obese human pregnancies. Adoption of standard protocols that more accurately mimic effects on fetal growth observed in obese human pregnancies will improve translational impact in this field. Electronic supplementary material The online version of this article (10.1186/s12958-019-0482-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of high-fat diets on fetal growth in rodents: a systematic review

Christians

Lennie

Wild

et al. 2019

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…In nutrient-restricted ewes, CD36 and Slc27a4/Fatp4 expression increased [71]; both genes also had elevated expression at the RNA level in obese ewes at midgestation [72]. On the other hand, in a rat model of diet-induced obesity that is associated with IUGR, mRNA and protein levels of CD36, Slc27a1/Fatp1 and Slc27a4/Fatp4 were reported as decreased relative to control [73]. It remains to be investigated to what extent altered transporter expression is linked to changes in fatty acid availability and metabolism.…”

Section: Discussionmentioning

confidence: 99%

Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy

et al. 2019

View full text Add to dashboard Cite

Diabetes in the mother during pregnancy is a risk factor for birth defects and perinatal complications and can affect long-term health of the offspring through developmental programming of susceptibility to metabolic disease. We previously showed that Streptozotocin-induced maternal diabetes in mice is associated with altered cell differentiation and with smaller size of the placenta. Placental size and fetal size were affected by maternal diet in this model, and maternal diet also modulated the risk for neural tube defects. In the present study, we sought to determine the extent to which these effects might be mediated through altered expression of nutrient transporters, specifically glucose and fatty acid transporters in the placenta. Our results demonstrate that expression of several transporters is modulated by both maternal diet and maternal diabetes. Diet was revealed as the more prominent determinant of nutrient transporter expression levels, even in pregnancies with uncontrolled diabetes, consistent with the role of diet in placental and fetal growth. Notably, the largest changes in nutrient transporter expression levels were detected around midgestation time points when the placenta is being formed. These findings place the critical time period for susceptibility to diet exposures earlier than previously appreciated, implying that mechanisms underlying developmental programming can act on placenta formation.

show abstract