RETRACTED ARTICLE: Effect of Maternal Iron Deficiency Anaemia on the Expression of Iron Transport Proteins in the Third Trimester Placenta

Mullapudi, Surekha Venkata; Sujatha, Thathapudi; Gadhiraju, Shravanthi; Kotturu, Sandeep Kumar; Prasad, Mudili Siva; Sarada, K; Bhaskar, V. Vijaya; Kumar, Parvinder

doi:10.1080/15513815.2020.1725942

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…The iron binds transferrin receptor TfR1 [45,46] and enters placental trophoblast cells, then discharges the cells under the action of DMT1 [46][47][48] and FPN1 [49,50] . Further, it can also enter the trophoblast cells through the mediation of divalent metal transporter ZIP family [51][52][53][54] , and then transfer iron through the action of DMT1 and FPN1.…”

Section: Discussionmentioning

confidence: 99%

Effects of Maternal Dietary Enteromorpha prolifera Polysaccharide Iron Supplement on Mineral Elements and Iron Level of Neonatal Piglets

Liu,

Gao,

Liu

et al. 2023

Biol Trace Elem Res

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Iron plays a key role in maternal health during pregnancy and fetal growth. Enteromorpha polysaccharide -iron (EP-Fe) as an organic iron chelate may improve the iron transmission of mother and offspring, ameliorate the poor pregnancy outcomes of sows, and alleviate the growth restriction of piglets caused by iron de ciency. This study aimed to evaluate the effects of maternal dietary supplementation with EP-Fe on reproductive performance and placental iron transmission of sows, as well as growth performance of piglets. Sixty pregnant sows at the 95th day of gestation were randomly divided into control group (CON) and EP-Fe group (EP-Fe, 139 mg kg − 1 ). Blood samples of sows and neonatal piglets, colostrum, and tissue samples were collected on the day of delivery. The animal experiment ended at the 21th day of post-delivery. Results showed that maternal dietary EP-Fe increased colostrum iron (P < 0.05) of sows, as well as nal litter weight (P < 0.05) and average daily weight of piglets (P < 0.05) during d 1-21 of lactation, as well as iron and manganese content in umbilical cord blood (P < 0.05) and hepatic iron of neonatal piglets (P < 0.01), and decreased fecal iron (P < 0.001), serum calcium (P < 0.05), phosphorus (P < 0.05) and zinc (P < 0.01) in the parturient sow. RT-qPCR results showed that FPN1 and SLC39A14 in placenta, as well as TfR1 and SLC39A14 in duodenum of neonatal piglets were activated by maternal EP-Fe supplement. These ndings suggest that maternal dietary EP-Fe could increase iron storage of neonatal piglets via improving placental iron transport and iron secretion in colostrum, thus enhance the growth performance of sucking piglets.

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Section: Discussionmentioning

confidence: 99%

Effects of Maternal Dietary Enteromorpha prolifera Polysaccharide Iron Supplement on Mineral Elements and Iron Level of Neonatal Piglets

Liu,

Gao,

Liu

et al. 2023

Biol Trace Elem Res

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“…The mechanisms behind this association are not fully understood but studies have postulated a compensatory placental hypertrophy in response to maternal anemia [ 29 ]. We know that there is an upregulation of placental iron transport proteins such as ferroportin in placentas of anaemic mothers [ 36 ]. We also know that there is increased expression of angiogenic proteins such as vascular endothelial growth factor in the placentas of anaemic mothers which may be responsible for the hypertrophic placental response to maternal anemia [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary intakes of iron, folate, and vitamin B12 during pregnancy and correlation with maternal hemoglobin and fetal growth: findings from the ROLO longitudinal birth cohort study

Rooney

Conway

O’Keeffe

et al. 2023

Arch Gynecol Obstet

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Purpose Dietary micronutrient intakes of iron, folate and vitamin B12 are known to influence hemoglobin. Low maternal hemoglobin (maternal anemia) has been linked to low birthweight and other adverse health outcomes in the fetus and infant. Our primary aim was to explore relationships between maternal dietary micronutrient intakes, maternal full blood count (FBC) parameters and fetal abdominal circumference (AC) and estimated fetal weight (EFW) growth trajectories. Secondarily, we aimed to assess relationships between maternal dietary micronutrient intakes, maternal hemoglobin values and placental weight and birthweight. Methods Mother–child pairs (n = 759) recruited for the ROLO study were included in this analysis. Maternal dietary micronutrient intakes were calculated from food diaries completed during each trimester of pregnancy. FBC samples were collected at 13- and 28-weeks’ gestation. Fetal ultrasound measurements were recorded at 20- and 34-weeks’ gestation. Growth trajectories for AC and EFW were estimated using latent class trajectory mixture models. Results Dietary intakes of iron and folate were deficient for all trimesters. Mean maternal hemoglobin levels were replete at 13- and 28-weeks’ gestation. Dietary iron, folate and vitamin B12 intakes showed no associations with fetal growth trajectories, placental weight or birthweight. Lower maternal hemoglobin concentrations at 28 weeks’ gestation were associated with faster rates of fetal growth and larger placental weights and birthweights. Conclusion The negative association between maternal hemoglobin at 28 weeks’ gestation and accelerated fetal and placental growth may be due to greater consumption of maternal iron and hemoglobin by fetuses’ on faster growth trajectories in addition to placental biochemical responses to lower oxygen states.

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“…This markedly increased need for iron is necessary to support the mother's blood volume as well as the growth of the fetus and placenta. Additionally, iron loss occurs in pregnant women both before and after birth [ 10 - 11 ]. About 1000 mg of iron are lost overall during pregnancy and lactation.…”

Section: Reviewmentioning

confidence: 99%

Iron Deficiency Anemia in Pregnancy

Raut¹,

Hiwale²

2022

Cureus

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Through its functions in oxygen delivery, electron transport, and enzymatic activity, iron is crucial for the operation of all cells. High metabolic rate cells need more iron and are more likely to malfunction when there is an iron deficit. Since the mother's blood volume expands during pregnancy, and the fetus grows and develops, there is a sharp increase in the need for iron. Negative pregnancy outcomes, such as increased maternal sickness, low birthweight, preterm, and intrauterine growth restriction, are linked to iron deficiency. IDA, or nutritional iron deficiency anemia, affects more than two billion people worldwide and is the most prevalent disease. Based on the regression-based analysis, the prevalence of anemia in the World Health Organization's global database was calculated to be 14%. According to recent data, there are 17.4% more IDA cases among pregnant women in industrialized countries than in poor ones (up to 56% more cases). Despite the fact that oral iron supplementation is frequently used to treat IDA, not all patients benefit from oral iron therapy. This is caused by a number of things, which include the adverse effects of oral iron, resulting in low compliance and ineffectiveness. In a sizable group of patients taking oral iron preparations, the adverse effects primarily include GI symptoms. Intravenous iron was previously underutilized since it was linked to unfavorable and occasionally dangerous side effects. New type II and III iron complexes have been created recently, though, and they offer superior compliance and toleration in addition to strong efficacy and a good safety profile.

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RETRACTED ARTICLE: Effect of Maternal Iron Deficiency Anaemia on the Expression of Iron Transport Proteins in the Third Trimester Placenta

Cited by 5 publications

References 32 publications

Effects of Maternal Dietary Enteromorpha prolifera Polysaccharide Iron Supplement on Mineral Elements and Iron Level of Neonatal Piglets

Effects of Maternal Dietary Enteromorpha prolifera Polysaccharide Iron Supplement on Mineral Elements and Iron Level of Neonatal Piglets

Dietary intakes of iron, folate, and vitamin B12 during pregnancy and correlation with maternal hemoglobin and fetal growth: findings from the ROLO longitudinal birth cohort study

Iron Deficiency Anemia in Pregnancy

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