Effect of maternal feed restriction in dairy goats at different stages of gestation on skeletal muscle development and energy metabolism of kids at the time of births

Costa, Thaís Correia; Moura, Felipe Henrique de; Souza, Ranyeri; Lopes, M. M.; Santos, Marta Maria dos; Serão, Nick V. L.; Sanglard, Letícia P; Du, Min; Gionbelli, Mateus Pies; Duarte, Márcio de Souza

doi:10.1016/j.anireprosci.2019.05.006

Cited by 8 publications

(8 citation statements)

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“…Under the demand of hypertrophy, these cells may proliferate and fuse with existing muscle fibers [27]. Previous studies have shown that maternal feed restriction did not alter the expression of PAX7 in goats [14], as well as the number of satellite cells in sheep [28]. A prenatal low protein diet resulted in reduced cell number, but the expression of PAX7 and myogenic markers were unaltered in the skeletal muscle of young and adult rats [29].…”

Section: Discussionmentioning

confidence: 99%

“…Among the factors affecting meat quality, the composition of muscle fibers [9], intramuscular fat (marbling level) [10] and connective tissue structure [11] may be, at least partially, manipulated during the prenatal stage in order to produce a desirable final body composition. Although many studies have reported the negative effects of maternal restriction during gestation on offspring skeletal muscle [12][13][14], there were no studies addressing long-term effect of maternal protein restriction during mid-gestation in beef cattle. Moreover, it remains unclear whether the negative changes can be partially rescued during postnatal stages.…”

Section: Introductionmentioning

confidence: 99%

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Skeletal Muscle Development in Postnatal Beef Cattle Resulting from Maternal Protein Restriction during Mid-Gestation

Costa

Nascimento

et al. 2021

Animals

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We aimed to investigate the effects of maternal protein restriction during mid-gestation on the skeletal muscle composition of the offspring. In the restriction treatment (RES, n = 9), cows were fed a basal diet, while in the control (CON, n = 9) group cows received the same RES diet plus the protein supplement during mid-gestation (100–200d). Samples of Longissimus dorsi muscle were collected from the offspring at 30d and 450d postnatal. Muscle fiber number was found to be decreased as a result of maternal protein restriction and persisted throughout the offspring’s life (p < 0.01). The collagen content was enhanced (p < 0.05) due to maternal protein restriction at 30d. MHC2X mRNA expression tended to be higher (p = 0.08) in RES 30d offspring, however, no difference (p > 0.05) was found among treatments at 450d. Taken together, our results suggest that maternal protein restriction during mid-gestation has major and persistent effects by reducing muscle fiber formation and may slightly increase collagen accumulation in the skeletal muscle of the offspring. Although maternal protein restriction may alter the muscle fiber metabolism by favoring the establishment of a predominant glycolytic metabolism, the postnatal environment may be a determinant factor that establishes the different proportion of muscle fiber types.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skeletal Muscle Development in Postnatal Beef Cattle Resulting from Maternal Protein Restriction during Mid-Gestation

Costa

Nascimento

et al. 2021

Animals

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“…The effects of maternal nutrition plan over gestation on the maternal average daily gain (ADG), ADG of maternal tissues (i.e., tissue accretion related to maternal tissues discounting all tissues increase due to the pregnancy), maternal DM and nutrients intake, as well as on the offspring birth body weight Development of the gastrointestinal tract of newborn goats under maternal feed restriction at different stages... Santos et al and their blood parameters, were previously reported in our complementary study (Costa et al, 2019).…”

Section: Maternal Performance and Intake And Offspring Performance An...mentioning

confidence: 70%

“…09/2017). Additional experimental details have been previously reported in our complementary study (Costa et al, 2019).…”

Section: Methodsmentioning

confidence: 99%

Development of the gastrointestinal tract of newborn goats under maternal feed restriction at different stages of gestation

Santos,

Costa,

Souza

et al. 2023

Revista Brasileira De Zootecnia

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This study evaluated how nutritional insults applied at different stages of intrauterine development affect the growth and development of total tract organs and the mRNA expression of genes that encode growth factors, tight junction proteins, digestive enzymes, and glucose transporters in the small intestine of newborn goats. Fourteen nulliparous dairy goats were assigned to one of two nutritional plans over gestation: maintenance-restriction (M-R, n = 8) -100% of maintenance requirement from d 8-84 of gestation followed by feeding at 50% maintenance requirement from d 85 of gestation to parturition; or restriction-maintenance (R-M, n = 6) -50% of maintenance requirement from d 8-84 of gestation followed by feeding at 100% maintenance requirement from d 85 of gestation to parturition. Fisher's least significant difference test was performed using SAS 9.4, considering a full fixed-effect model. When expressed per kg of body weight, the weights of the small intestine and total intestine were 18.7 and 18.1% lower, respectively, for R-M offspring. The lengths of the small intestine and the total intestine of the R-M newborns were 19.1 and 9.5% shorter, respectively. This group also had a lower villus height:intestinal crypt depth ratio. The R-M offspring tended to have lower Solute carrier family 5 member 1 (SLC5A1), Solute carrier family 2 member 2 (SLC2A2), and Occludin (OCLN) mRNA expressions. Therefore, feed restriction in the first half of gestation is detrimental to the second half of gestation, reducing the offspring's intestinal absorptive area but enhancing their intestinal permeability.

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“…Similarly, the energy restriction during late gestation contributes to the downregulation of genes involved in the oxidative metabolism, and consequently favoring the less efficient glycolytic metabolism in the skeletal muscle of calves ( Sanglard et al, 2018 ). Although no phenotypic differences were observed in the skeletal muscle of the newborn goats, resulting from maternal feed restriction at different stages of gestation ( Costa et al, 2019 ), the skeletal muscle transcriptome profile was altered, resulting in differentially expressed genes that are involved with skeletal muscle development and energy metabolism ( Costa et al, 2021b ).…”

Section: Fetal Programming and The Efficiency For The Deposition Of Muscle And Fatmentioning

confidence: 99%

Fetal programming in ruminant animals: understanding the skeletal muscle development to improve meat quality

2021

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Effect of maternal feed restriction in dairy goats at different stages of gestation on skeletal muscle development and energy metabolism of kids at the time of births

Cited by 8 publications

References 41 publications

Skeletal Muscle Development in Postnatal Beef Cattle Resulting from Maternal Protein Restriction during Mid-Gestation

Skeletal Muscle Development in Postnatal Beef Cattle Resulting from Maternal Protein Restriction during Mid-Gestation

Development of the gastrointestinal tract of newborn goats under maternal feed restriction at different stages of gestation

Fetal programming in ruminant animals: understanding the skeletal muscle development to improve meat quality

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