Effect of Maternal Diabetes on Hippocampus Neuronal Density in Neonatal Rats

Diabetes during pregnancy enhanced neuronal death in the hippocampus of rat offspring

“…Our study results show that uncontrolled hyperglycemia during gestational period significantly decreased total neuronal density in hippocampal CA3 subfields at P0. This finding is in consistent with the finding of the study conducted by Tehranipour and Khakzad (2008). They demonstrated that diabetes in pregnancy could reduce the number of hippocampal neurons, especially in CA3 area.…”

“…The results from the majority of experimental studies also indicate that diabetes negatively impacts hippocampal cell proliferation and survival (Ho et al, 2013; Chen et al, 2012; Foghi and Ahmadpour, 2013; Li et al, 2002a,b; Jafari Anarkooli et al, 2008). On the other hands, some of experimental studies revealed a reduction in the numerical densities of neurons in some portions of fetal CNS, especially in the hippocampus due to maternal diabetes which reflects in lower memory and learning skills and defect in memory storage (Ghafari et al, 2015; Razi et al, 2014; Golalipour et al, 2012; Khaksar et al, 2011; Tehranipour and Khakzad, 2008). Meanwhile, there is no study that evaluated the impact of diabetes during pregnancy period on neuronal cell apoptosis in different sub‐regions of rat hippocampus during brain development.…”

Effect of streptozotocin-induced diabetes mellitus on the cerebellar cortex of adult male albino rats

“…All rats that presented with a fasting blood glucose level higher than 250 mg/dl were considered as diabetic [15]. These rats were anesthetized with ether inhalation and scarified at 8 weeks [14] after the onset of DM. The skull was opened; the cerebellum was dissected out carefully and processed for the following procedures.…”

“…(3) Group III: Ten rats received STZ as the diabetogenic agent (Sigma Chemical Company, St Louis, Missouri, USA), and the vehicle for administration was the saline. Each rat was administered a single intraperitoneal injection of STZ at a dose of 60 mg/kg body weight freshly dissolved in 0.1 ml saline under anesthesia [14]. Fasting blood samples were taken from the dorsal vein of rats' tails.…”

Cognitive Function in Offspring of Mothers with Gestational Diabetes–The Role of Insulin receptor

“…Tehranipour et al [48] were examined the effects of maternal diabetes on density of hippocampal pyramidal cells immediately after birth and indicated that diabetes in pregnancy period can decreased the numerical density of pyramidal cells in the hippocampus of rat newborns [48]. Recent studies have also clearly established that gestational diabetes in pregnancy disrupts the regulation of InsR in the hippocampus and cerebellum of neonatal rats.…”