Effect of maternal diabetes and hypercholesterolemia on fetal liver of albino Wistar rats

El‐Sayyad, Hassan I.; Al-Haggar, Mohamed M.S.; El-Ghawet, Heba A.; Bakr, Iman H.

doi:10.1016/j.nut.2013.08.016

Cited by 23 publications

(14 citation statements)

References 56 publications

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“…Similarly to previous studies, we have observed that pups from dams fed a DLP diet had low weight at birth and weaning, but recovered normal body weight at 30 d of age (14,35) . Interestingly, a recent meta-analysis of clinical trials found that maternal dyslipidaemia during pregnancy was associated with an increased risk of preterm birth (10) .…”

Section: Discussionsupporting

confidence: 87%

Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

et al. 2017

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The present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0·04 %), were recorded from awake 90-d-old male offspring. DLP dams exhibited raised serum levels of total cholesterol (TC) (4·0-fold), TAG (2·0-fold), VLDL+LDL (7·7-fold) and reduced HDL-cholesterol (2·4-fold), insulin resistance and hepatic steatosis at the end of lactation. At 30 d of age, the DLP offspring showed an increase in the serum levels of TC (P<0·05) and VLDL+LDL (P<0·05) in comparison with CTL offspring. At 90 d of age, DLP offspring exhibited higher mean arterial pressure (MAP, approximately 34 %). In the spectral analysis, the DLP group showed augmented low-frequency (LF) power and LF:high-frequency (HF) ratio when compared with CTL offspring. In addition, the DLP animals showed a larger delta variation in arterial pressure after administration of the ganglionic blocker (P=0·0003). We also found that cardiorespiratory response to hypercapnia and hypoxia was augmented in DLP offspring. In conclusion, the present data show that maternal dyslipidaemia alters cardiorespiratory physiology and may be a predisposing factor for hypertension at adulthood.

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Section: Discussionsupporting

confidence: 87%

Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

et al. 2017

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“…GDM + S group presented a lipid profile similar to those found in Afiune et al [53] and El-Sayyad et al [54] studies, confirming the reproducibility of GDM induction by STZ, in which GDM-STZ rats presented increased levels of triglycerides and cholesterol and reduced HDL-chol. Spim et al [55], when evaluating the ingestion of Lentinus edodes associated with a high-fat diet, proved that this specie of mushroom has a hypocholesterolemic action, reducing total cholesterol and triglycerides levels.…”

Section: Discussionsupporting

confidence: 84%

Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

et al. 2019

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Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.

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“…Consistently with previous results, pups from dams fed a dyslipidemic diet had low weight at birth and weaning, but recovered normal bodyweight by 30 days of age . Taken together, the findings show that maternal nutrition may modulate a range of anthropometric and cardiovascular parameters in offspring, reinforcing the idea that an adequate nutritional environment during pregnancy and lactation is critical for satisfactory offspring health and development.…”

Section: Discussionsupporting

confidence: 90%

Short‐ and long‐term effects of maternal dyslipidaemia on blood pressure and baroreflex sensitivity in male rat offspring

Araújo

Santos

Speretta

et al. 2019

Clin Exp Pharma Physio

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Nutritional insults during pregnancy and/or lactation phases increase the risk in offspring for future arterial hypertension. 1-3 Maternal dyslipidaemia is a condition characterized by high levels of total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein (LDL) and decreased high-density lipoprotein (HDL). 4 Although pregnancy and/or lactation can be recognized as a period of life favourable to increased lipid profile in serum, 5 the dyslipidaemia effects on the offspring are poorly understood. We have developed a maternal diet-induced dyslipidaemic model in rats, characterized by increased serum levels of total cholesterol, LDL-cholesterol, and triacylglycerol, reduced HDL-cholesterol and compromised glucose tolerance and insulin sensitivity in dams.

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Effect of maternal diabetes and hypercholesterolemia on fetal liver of albino Wistar rats

Cited by 23 publications

References 56 publications

Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

Short‐ and long‐term effects of maternal dyslipidaemia on blood pressure and baroreflex sensitivity in male rat offspring

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