Effect of Maternal ±Citalopram Exposure on P11 Expression and Neurogenesis in the Mouse Fetal Brain

King, Jennifer R.; Velasquez, Juan C.; Torii, Masaaki; Bonnin, Alexandre

doi:10.1021/acschemneuro.6b00339

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…However, long term regulation of gene expression and epigenetic mechanisms are likely to occur after chronic administration. In this regard, it is important to mention that different classes of antidepressant drugs have been demonstrated to have a plethora of effects in CNS disorders and are also known to have a role in neurogenesis ( Wang et al, 2011 ; Masuda et al, 2012 ; Meneghini et al, 2014 ; Zhou et al, 2016 ; King et al, 2017 ). Many of these effects are sex-dependent ( Gray and Hughes, 2015 ; Kokras and Dalla, 2017 ) and fluoxetine itself is known to induce sex specific effects on neurogenesis ( Hodes et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice

et al. 2017

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Gender and sex differences in pain recognition and drug responses have been reported in clinical trials and experimental models of pain. Among antidepressants, contradictory results have been observed in patients treated with selective serotonin reuptake inhibitors (SSRIs). This study evaluated sex differences in response to the SSRI fluoxetine after chronic administration in the mouse formalin test. Adult male and female CD1 mice were intraperitoneally injected with fluoxetine (10 mg/kg) for 21 days and subjected to pain assessment. Fluoxetine treatment reduced the second phase of the formalin test only in female mice without producing behavioral changes in males. We also observed that fluoxetine was able to specifically increase the expression of metabotropic glutamate receptor type-2 (mGlu2) in females. Also a reduced expression of the epigenetic modifying enzyme, histone deacetylase 2 (HDAC2), in dorsal root ganglia (DRG) and dorsal horn (DH) together with an increase histone 3 acetylation (H3) level was observed in females but not in males. With this study we provide evidence that fluoxetine induces sex specific changes in HDAC2 and mGlu2 expression in the DH of the spinal cord and in DRGs and suggests a molecular explanation for the analgesic effects in female mice.

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Section: Discussionmentioning

confidence: 99%

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice

et al. 2017

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“…Cell proliferation was attenuated by fluoxetine (antidepressant drug) in the subgranular zone in hippocampus of P11 KO mice, compared with WT mice [44]. Furthermore, P11 was also expressed in fetal cortex, thalamus, hippocampus, and hypothalamus at gestation day 17, and a decreased expression of P11 after exposure of citalopram (antidepressant drug) in uterus led to significantly decreased neurogenesis in relevant fetal brain regions [67]. In addition, down-regulation of P11 with siRNA or microRNA decreased cell proliferation in cancer cell lines [68][69][70].…”

Section: Discussionmentioning

confidence: 99%

P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice

Liu¹,

Wang²,

Zheng³

et al. 2019

Int. J. Biol. Sci.

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Although depression is associated with anxiety and memory deficit in humans, the molecular mechanisms of the complication remain largely unknown. In this study, we generated P11 knockout mice using CRISPR/Cas9 technology, as well as P11 knockout MEF cell lines, and confirmed depression-like phenotype. We observed that knockout of P11 in MEFs led to a decreased cell proliferation compared with P11 +/+ MEFs. Moreover, P11 knockout resulted in a larger cell size, which resulted probably from accumulated F-actin stress fibers. The number of proliferating cells was decreased in the hippocampus of P11 KO mice. We observed anxiety-like disorder in addition to depression phenotype in the knockout mice. In addition, knockout of P11 led to memory deficit in female mice, but not in males. These data indicated that P11 is involved in regulating cell proliferation and cell size. The molecular associations of depression behavior with anxiety and memory deficit suggested a potential approach to improve therapeutic intervention through P11 in these disorders.

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“…King and colleagues researched that fetal exposure to SSRI not only increases the serotonin level but also modulates p11 expression and neurogenesis in mice [ 46 ]. p11 protein was recently considered a crucial component of 5-HT signaling pathway through the complex formation with 5-HT 1B/1D receptors in adult [ 47 ].…”

Section: 5-ht 1 Receptor (5-ht 1 ...mentioning

confidence: 99%

Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment

Lee

Choo

Jeon

2022

IJMS

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Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by repetitive and stereotyped behaviors as well as difficulties with social interaction and communication. According to reports for prevalence rates of ASD, approximately 1~2% of children worldwide have been diagnosed with ASD. Although there are a couple of FDA (Food and Drug Administration)—approved drugs for ASD treatment such as aripiprazole and risperidone, they are efficient for alleviating aggression, hyperactivity, and self-injury but not the core symptoms. Serotonin (5-hydroxytryptamine, 5-HT) as a neurotransmitter plays a crucial role in the early neurodevelopmental stage. In particular, 5-HT has been known to regulate a variety of neurobiological processes including neurite outgrowth, dendritic spine morphology, shaping neuronal circuits, synaptic transmission, and synaptic plasticity. Given the roles of serotonergic systems, the 5-HT receptors (5-HTRs) become emerging as potential therapeutic targets in the ASD. In this review, we will focus on the recent development of small molecule modulators of 5-HTRs as therapeutic targets for the ASD treatment.

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Effect of Maternal ±Citalopram Exposure on P11 Expression and Neurogenesis in the Mouse Fetal Brain

Cited by 7 publications

References 33 publications

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice

P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice

Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment

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