Effect of maternal borderline personality disorder on adolescents’ experience of maltreatment and adolescent borderline features.

Liu²,

et al. 2020

Preprint

Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates who had BPD or antisocial personality disorder (ASPD) or highly impulsive or violent crime were considered as high-risk inmates and included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group (inmates with BPD features) had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group, while the statistical significances were lost after Bonferroni correction. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

Section: Discussionmentioning

confidence: 99%

Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder Features among Male Inmates in China

Liu²,

et al. 2020

Preprint

“…The prior literature reported that adolescents whose mothers had BPD experienced more maltreatment compared with those whose mothers were normal [50], which revealed that the intergenerational transmission of BPD may be through childhood maltreatment. Another study showed that mothers' maltreatment history was a more strongly prediction for mother-infant attachment disorganization score among mothers with more plasticity alleles of OXTR gene [51], which suggested that maternal maltreatment history would influence offspring depending on the maternal genetic characteristics.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder among Male Inmates in China

Liu²,

et al. 2019

Preprint

Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates with high risk were included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the highrisk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse.Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

“…The prior literature reported that more adolescents whose mothers had BPD experienced maltreatment than those whose mothers were normal and maltreatment could predict borderline features [34], which revealed that the intergenerational transmission of BPD may be through childhood maltreatment. Another study showed that mothers' maltreatment history is a more strongly prediction for mother-infant attachment disorganization score among mothers with more plasticity alleles of OXTR [35], which suggested that maternal maltreatment history would influence offspring depending on the maternal genetic characteristics.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder among Male Inmates in China

Liu²,

et al. 2019

Preprint

Background Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interaction between OXTR gene polymorphism and childhood maltreatment in BPD. Methods A total of 1804 prison inmates and 196 normal controls participated in this study. Childhood maltreatment was measured by a self-reported questionnaire, as was BPD. Venous blood was collected for the genotype test. Results Analyses revealed that the BP group had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group. Childhood maltreatment and its dimension could positively predict BPD risk. Among the prison samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of emotional abuse, physical abuse and sexual abuse and lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions The finding suggests that the interaction between childhood maltreatment and OXTR gene variations is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.