Effect of maternal anxiety on maternal serum and fetal cord blood cortisol

Keshavarzi, Farahnaz; Farnia, Vahid; Yazdchi, Katayoun; Najafi, Farid; Brand, Serge; Bajoghli, Hafez; Nankali, Anisodowleh; Salmanzadeh, Habib

doi:10.1111/appy.12125

Cited by 11 publications

(12 citation statements)

References 18 publications

(19 reference statements)

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“…Not less important for an optimal pregnancy is a healthy psychological status [ 31 , 32 , 96 ]. In that sense, exercise represent an excellent opportunity to improve quality of life [ 33 ] and reduce cortisol levels, which may in turn have a positively influence on the foetus and child [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…An optimal mental health during pregnancy is also a major concern. High levels of depression or anxiety during gestation and post-partum affect maternal quality of life, and in turn, could have a negative influence on the foetal and child health [ 31 , 32 ]. Exercise may improve the pregnant quality of life and reduce stress [ 33 – 36 ], which might protect the foetus [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…High levels of depression or anxiety during gestation and post-partum affect maternal quality of life, and in turn, could have a negative influence on the foetal and child health [ 31 , 32 ]. Exercise may improve the pregnant quality of life and reduce stress [ 33 – 36 ], which might protect the foetus [ 31 ]. Also, adequate sleep during gestation improves quality of life [ 37 ], prevents stress and depression [ 38 – 40 ] and GDM [ 41 , 42 ], reduces inflammatory signal [ 43 ] and the incidence of preeclampsia, premature birth or caesarea [ 44 – 46 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of supervised aerobic and strength training in overweight and grade I obese pregnant women on maternal and foetal health markers: the GESTAFIT randomized controlled trial

Aparicio

Ocón

Padilla-Vinuesa

et al. 2016

BMC Pregnancy Childbirth

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BackgroundDuring pregnancy, a sedentary lifestyle may have negative consequences on maternal and foetal health status. The main objective of this project is to assess the effects of an exercise intervention in overweight and grade I obese pregnant on maternal and foetal health markers.Methods/designThe present study aims to recruit 60 overweight and grade I obese women interested in participating in an exercise intervention program from the 17th gestational week until delivery. Women will be randomized to either an exercise (three 60-min sessions/week of combined aerobic and strength training and pelvic floor exercises), or usual care (control) group (30 women per group). The primary outcome measures are maternal weight gain, and maternal and neonatal glycaemic profile. Secondary outcome measures are: i) perinatal obstetric records; i) body composition; iii) dietary patterns; iv) physical fitness; v) low-back pain; vi) objectively measured physical activity and sedentary behaviour; vii) haematology and biochemical analyses; viii) oxidative stress; ix) pro- and anti-inflammatory markers; x) bone health biomarkers; xi) sleep quality; xii) mental health, quality of life and positive health.DiscussionThe findings of this project will help to identify strategies for primary prevention and health promotion based on this exercise-based intervention program among overweight and grade I obese pregnant women.Trial registration NCT02582567; Date of registration: 20/10/2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of supervised aerobic and strength training in overweight and grade I obese pregnant women on maternal and foetal health markers: the GESTAFIT randomized controlled trial

Aparicio

Ocón

Padilla-Vinuesa

et al. 2016

BMC Pregnancy Childbirth

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“…Glover et al [13] have shown a stronger correlation between maternal and fetal cortisol among more anxious pregnant women. In addition, Keshavarzi et al [7] have reported that higher maternal anxiety is associated with an increase in fetal cord blood cortisol.…”

Section: Discussionmentioning

confidence: 99%

“…Maltau et al [6] have shown that maternal anxiety is associated with reduced concentrations of estriol in maternal plasma. In addition, it has been documented that high maternal anxiety increases cortisol in maternal serum and also in fetal cord blood [7]. Other studies have reported that higher cortisol levels affect the syntheses or the serum levels of estriol, AFP, and inhibin [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Maternal Anxiety and the Second-Trimester Prenatal Screening: A Prospective Cohort Study

Mousavi¹,

Hantoushzadeh²,

Sheikh³

et al. 2015

Fetal Diagn Ther

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Objective: Assessing the effects of maternal anxiety on the markers and results of quadruple screening and on maternal anxiety after receiving positive results. Methods: This prospective cohort study evaluated 1,595 pregnant women referred for prenatal visits. Maternal state/trait anxiety levels were measured, then quadruple screening was performed by measuring serum α-fetoprotein (AFP), β-human chorionic gonadotropin, inhibin A, and unconjugated estriol (UE3). After receiving the results, the state/trait anxiety was remeasured. Amniocentesis was performed for screening-positive mothers. Results: High prescreening maternal anxiety was associated with lower rates of elevated AFP (OR, 0.27; 95% CI, 0.1-0.74) and elevated inhibin A (OR, 0.38; 95% CI, 0.15-0.98). High maternal anxiety was associated with higher rates of decreased UE3 (OR, 1.8; 95% CI, 1.06-3.08). There were no significant associations between prescreening maternal anxiety and the final screening or amniocentesis results. Among the screening-positive mothers, those who had high state/trait anxiety before screening had higher anxiety scores after receiving positive results compared to those with low prescreening anxiety levels (52.9 ± 10.8 vs. 43.7 ± 10.3). Conclusion: High prescreening maternal anxiety is associated with lower rates of elevated AFP and inhibin A and higher rates of decreased UE3. However, maternal anxiety does not affect the final screening or amniocentesis result. High maternal state/trait anxiety before screening is associated with significantly higher maternal anxiety after the receipt of positive results.

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Low-dose midazolam for anxiolysis for pregnant women undergoing cesarean delivery: a randomized trial

Oliveira

Sant’Anna

Seixas

et al. 2022

Brazilian Journal of Anesthesiology (English Edition)

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Effect of maternal anxiety on maternal serum and fetal cord blood cortisol

Abstract: These data suggested that high maternal trait anxiety increases fetus cord blood cortisol and may regulate fetal growth.

Cited by 11 publications

References 18 publications

Effects of supervised aerobic and strength training in overweight and grade I obese pregnant women on maternal and foetal health markers: the GESTAFIT randomized controlled trial

Effects of supervised aerobic and strength training in overweight and grade I obese pregnant women on maternal and foetal health markers: the GESTAFIT randomized controlled trial

Maternal Anxiety and the Second-Trimester Prenatal Screening: A Prospective Cohort Study

Low-dose midazolam for anxiolysis for pregnant women undergoing cesarean delivery: a randomized trial

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