Effect of maternal antibodies and pig age on the antibody response after vaccination against Glässers disease

Abstract

The influence of age and maternal antibodies on the development and duration of postvaccinal antibody response against Glässer's disease were investigated. Pigs born to immune (MDA-positive) and non-immune (MDA-negative) sows were vaccinated with inactivated vaccine. Vaccination was done according to three different protocols: at 1 and 4, at 2 and 5 or at 4 and 7 weeks of age. There were also two control groups for MDA-negative and MDA-positive pigs. The level of Haemophilus parasuis (Hps) specific antibodies were determined using commercial ELISA test. No serological responses were seen in any of the groups after the first vaccination. Maternally derived antibodies (MDA) against Hps were above the positive level until approximately 3 weeks of life in MDA-positive pigs. In those pigs the strongest postvaccinal humoral response was observed in piglets vaccinated at 4 and 7 weeks of age. In the remaining MDA-positive piglets only slight seroconversion was noted but levels of antibodies never exceeded values considered as positive. All MDA-negative pigs produced Hps-specific antibodies after the second vaccination. The results of the present study indicated that MDA may alter the development and duration of active postvaccinal antibody response. Age of pigs at the moment of vaccination was not associated with the significant differences in the magnitude of antibody response, however influenced the kinetics of decline of Hps-specific antibodies.

Polymicrobial respiratory disease in pigs

“…The age and breed of the pig at the time of infection can also be of importance. PRDC is predominantly seen in grow–finish pigs, typically around 12–24 weeks of age, and may be associated with waning of passively acquired antibodies (Thanawongnuwech et al , 1998 b ; Cho et al , 2006; Pomorska-Mól et al , 2011). To the authors’ knowledge, to date no specific resistance factors to respiratory pathogens have been identified in pigs.…”

Field evaluation of the efficacy, compatibility and serologic profiling of a combined vaccine against porcine reproductive and respiratory syndrome and Haemophilus parasuis in nursery pigs

“…Maternal derived antibodies can have a negative influence on the antibody response after vaccination (Pomorska-Mól et al, 2011). In the presented study the pigs were negative in the oppA-ELISA at time of vaccination.…”

Haemophilus parasuis α-2,3-sialyltransferase-mediated lipooligosaccharide sialylation contributes to bacterial pathogenicity

“…For examples, maternal antibody reduction is a critical factor that allows the development of H. parasuis infection. Sow-reared piglets are usually protected against early infection of H. parasuis via acquisition of the maternal antibody [25], whereas the colostrums-deprived piglets are extremely susceptible to the systemic infection [26]. Selective pressure from the antibiotics sometimes induces the disease by the emergence of antimicrobial-resistance strains and the diversity of the isolates, thereby facilitating the distribution of H. parasuis [27].…”