Effect of maternal and treatment‐related factors on the prevalence of birth defects after <scp>PESA</scp>‐<scp>ICSI</scp> and <scp>TESE</scp>‐<scp>ICSI</scp>: a retrospective cohort study

Meijerink, A.M.; Oomen, Reinoud E.; Fleischer, Kathrin; IntHout, Joanna; Woldringh, G.H.; Braat, D.D.M.

doi:10.1111/aogs.12728

Cited by 4 publications

(2 citation statements)

References 30 publications

(49 reference statements)

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“…Recent studies showed that children born following ART application have increased epigenetic anomalies compared with those conceived spontaneously [3][4][5][6][7]. Children who were born by using ART techniques seem to have more possibility of birth defects [8], congenital or chromosomal anomalies [9], and imprinting disorders such as Beckwith-Wiedemann, Silver Russell, Angelman, and Prader-Willi syndromes compared with spontaneously conceived babies [6,10].…”

Section: Introductionmentioning

confidence: 99%

Superovulation alters DNA methyltransferase protein expression in mouse oocytes and early embryos

Uysal

Öztürk

Akkoyunlu

2017

J Assist Reprod Genet

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Section: Introductionmentioning

confidence: 99%

Superovulation alters DNA methyltransferase protein expression in mouse oocytes and early embryos

Uysal

Öztürk

Akkoyunlu

2017

J Assist Reprod Genet

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“…ICSI is based on either ejaculated sperm or surgically acquired sperm; the surgical methods for acquiring sperm include percutaneous epididymal sperm aspiration (PESA), testicular sperm aspiration (TESA) and microdissection testicular sperm extraction (micro-TESE). The reported clinical outcomes based on the different methods of obtaining sperm are not uniform, and few studies have analyzed neonatal outcomes associated with the different sperm acquisition methods ( 5 – 7 ). Therefore, the purpose of this study was to explore the effects of different sperm sources for ICSI on the live birth rate (LBR) and neonatal outcomes to provide evidence for clinical consultation and treatment.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Neonatal Outcomes of Children Born After ICSI With or Without Surgically Acquired Sperm: A Retrospective Cohort Study

Zhang

Zhen

et al. 2022

Front. Endocrinol.

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ObjectiveThe purpose of this study was to explore the effects of different methods of obtaining sperm for intracytoplasmic sperm injection (ICSI) cycles on the live birth rate (LBR) and neonatal outcomes.MethodsThis was a single-center retrospective cohort study conducted from January 2016 to December 2019. A total of 3557 ICSI cycles were included in the analysis, including 540 cycles in the surgically acquired sperm group and 3017 cycles in the ejaculated sperm group. The main outcome measure was the LBR.ResultsThe clinical pregnancy rate in the surgically acquired sperm group was 69.4%, which was significantly higher than the 59.7% clinical pregnancy rate in the ejaculated sperm group (P=0.01). The LBR of the surgically acquired sperm group was significantly higher than that of the ejaculated sperm group (63.1% vs. 51.2%, P<0.01). Similarly, the singleton LBR was also higher in the surgically acquired sperm group than in the ejaculated sperm group (45.4% vs. 39.2%, P=0.04). Due to differences in the baseline characteristics of the two groups, multiple logistic regression analysis was performed. After multiple logistic regression analysis, the different methods of obtaining sperm were independent risk factors influencing the clinical pregnancy rate (adjusted odds ratio (AOR)=0.73, 95% confidence (CI)=0.56-0.95, P=0.02) and LBR (AOR=0.69, 95% CI=0.54-0.89, P=0.01). The preterm birth rate (AOR=1.42, 95% CI=0.62-3.25, P=0.41) and the incidence of low birth weight (AOR=1.03, 95% CI=0.45-2.34, P=0.95), small for gestational age (AOR=0.81, 95% CI=0.39-1.68, P=0.57), macrosomia (AOR=0.88, 95% CI=0.47-1.66, P=0.70) and large for gestational age (AOR=1.08, 95% CI=0.65-1.82, P=0.76) were not affected by the different methods.ConclusionThe clinical pregnancy rate and LBR of the surgically acquired sperm group were higher than those of the ejaculated sperm group. There was no significant difference between the neonatal outcomes of the two groups.

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Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods

Abhyankar

Ohlander

Kathrins

2018

Intracytoplasmic Sperm Injection

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Effect of maternal and treatment‐related factors on the prevalence of birth defects after PESA‐ICSI and TESE‐ICSI: a retrospective cohort study

Abstract: We found a similar overall prevalence of birth defects in newborns born after PESA-ICSI and TESE-ICSI. The maternal and treatment-related factors investigated did not show a significantly increased cumulative risk of birth defects.

Cited by 4 publications

References 30 publications

Superovulation alters DNA methyltransferase protein expression in mouse oocytes and early embryos

Superovulation alters DNA methyltransferase protein expression in mouse oocytes and early embryos

Clinical and Neonatal Outcomes of Children Born After ICSI With or Without Surgically Acquired Sperm: A Retrospective Cohort Study

Implications of Sperm Source on ICSI Outcome: Assessment of TESE and Other Surgical Sperm Retrieval Methods

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