Effect of maternal and neonatal factors on neonatal thyroid stimulating hormone: Results from a population-based prospective cohort study in China

Zhang, Yixin; Du, Cong; Wang, Wei; Chen, Wen; Shao, Ping; Wang, Chongdan; Leng, Junhong; Shen, Jun; Tan, Lei; Zhang, Wanqi

doi:10.1016/j.jtemb.2018.05.008

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…Inadequate intake of iodine in early pregnancy could result in decreased thyroid hormone synthesis, miscarriage, or stillbirth [33]. Follow-up data have shown that maternal BMI, TSH, and birth height were significantly correlated with neonatal TSH >5 mIU/L [34]. However, we must not ignore the influence of some other trace elements on foetal development, such as vitamin A, vitamin D, and folic acid [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Trimester-Specific Thyroid Function in Pregnant Women with Different Iodine Statuses

et al. 2020

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Objectives: To explore trimester-specific thyroid function changes under different iodine statuses throughout pregnancy. Methods: A cross-sectional study was conducted to assess the pregnancy iodine status, and 2,378 healthy pregnant women covering all 3 trimesters were recruited. Urinary iodine concentration (UIC) was measured by collecting spot urine samples. Blood samples were collected to evaluate thyroid function. Thyroid B-ultrasonography was conducted to measure the thyroid volume (Tvol). Results: The median UIC was 168 μg/L (111-263 μg/L). The UIC, free triiodothyronine (FT3), and free thyroxine (FT4) were significantly decreased as the pregnancy progressed (p < 0.001, p for trend <0.001), while Tvol increased (p < 0.001, p for trend <0.001). Thyrotropin (TSH) was significantly different between the 3 trimesters and showed an upward trend (p < 0.001), but the p for trend was not significant (p for trend = 0.88). After stratification by UIC, there were no significant differences in serum TSH, FT4, or FT3 level between UIC groups. Tvol was significantly higher in the UIC ≥500 μg/L group in the first trimester (β: 2.41, 95% CI: 1.09-3.72, p <0.001), as well as in the 250 ≤ UIC < 500 μg/L group (β: 1.65, 95% CI: 0.61-2.70, p < 0.001) and UIC ≥500 μg/L group (β: 3.35, 95% CI: 1.96-4.74, p < 0.001) in the third trimester. Conclusions: No difference was observed in TSH, FT3, or FT4 among the different iodine status groups throughout pregnancy. Tvol increased as the pregnancy progressed, and it was especially higher in the UIC ≥500 μg/L group in the first and third trimesters.

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Section: Discussionmentioning

confidence: 99%

Trimester-Specific Thyroid Function in Pregnant Women with Different Iodine Statuses

et al. 2020

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“…Such factors include shared genetic qualities, iodine consumption, dietary factors and exposures to exogenous pollutants. Our study, in addition to other recent studies, provides epidemiologic evidence of the connections between maternal and foetal thyroid hormone concentrations during pregnancy and the perinatal period; however, further investigations are warranted to determine the primary drivers of these relations.…”

Section: Discussionmentioning

confidence: 49%

“…Recent epidemiologic evidence suggests that prenatal maternal thyroid hormone concentrations and early‐life thyroid hormone concentrations in children are related . Researchers from the Generation R Study, a large prospective birth cohort study, recently reported that TSH and FT4 concentrations in prenatal maternal samples were strongly related with TSH and FT4 concentrations (respectively) in cord and 6‐year‐old child samples .…”

Section: Discussionmentioning

confidence: 99%

“…Study, a large prospective birth cohort study, recently reported that TSH and FT4 concentrations in prenatal maternal samples were strongly related with TSH and FT4 concentrations (respectively) in cord and 6-year-old child samples 7,8. Similarly, Zhang et al reported that prenatal maternal TSH and FT4 were positively associated with neonatal TSH concentrations among a large prospective cohort of Chinese mother-child pairs 10. We similarly observed relations between maternal and cord TSH, as well as cord and child TSH.…”

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confidence: 94%

“…Prior research suggests that prenatal maternal thyroid‐stimulating hormone (TSH) and free thyroxine (FT4) are associated with TSH and FT4 in offspring, respectively . Other investigations of maternal and newborn thyroid hormones among euthyroid mothers have yielded similar, but somewhat inconsistent findings . A sound understanding of relations between maternal thyroid function during pregnancy and offspring thyroid function serves several purposes: (a) improve our ability to identify pregnancies and children at risk for thyroid‐related disorders, (b) improve our understanding of prenatal and early‐life programming of thyroid function throughout the life course and (c) support conduct and interpretation of epidemiologic studies which utilize thyroid hormones as biomarkers of thyroid function during pregnancy and early life.…”

Section: Introductionmentioning

confidence: 99%

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Maternal, cord, and three‐year‐old child serum thyroid hormone concentrations in the Health Outcomes and Measures of the Environment study

Doherty

Kosarek

Hoofnagle

et al. 2020

Clinical Endocrinology

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Purpose Maternal thyroid function during pregnancy may influence offspring thyroid function, though relations between maternal and child thyroid function are incompletely understood. We sought to characterize relations between maternal, cord and child thyroid hormone concentrations in a population of mother‐child pairs with largely normal thyroid function. Methods In a prospective birth cohort, we measured thyroid hormone concentrations in 203 mothers at 16 gestational weeks, 273 newborns and 159 children at 3 years among participants in the Health Outcomes and Measures of the Environment (HOME) Study. We used multivariable linear regression to estimate associations of maternal thyroid hormones during pregnancy with cord serum thyroid hormones and also estimated associations of maternal and cord thyroid hormones with child thyroid‐stimulating hormone (TSH). Results Each doubling of maternal TSH was associated with a 16.4% increase of newborn TSH (95% CI: 3.9%, 30.5%), and each doubling of newborn TSH concentrations was associated with a 10.4% increase in child TSH concentrations at 3 years (95% CI: 0.1%, 21.7%). An interquartile range increase in cord FT4 concentrations was associated with an 11.7% decrease in child TSH concentrations at 3 years (95% CI: −20.2%, −2.3%). Conclusions We observed relationships between maternal, newborn and child thyroid hormone concentrations in the HOME Study. Our study contributes to understandings of interindividual variability in thyroid function among mother‐child pairs, which may inform future efforts to identify risk factors for thyroid disorders or thyroid‐related health outcomes.

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Neonatal TSH as a marker of iodine nutrition status. Effect of maternal ioduria and thyroid function on neonatal TSH

González-Martínez¹,

García²,

Gomis³

et al. 2022

Anales de Pediatría (English Edition)

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Effect of maternal and neonatal factors on neonatal thyroid stimulating hormone: Results from a population-based prospective cohort study in China

Cited by 13 publications

References 24 publications

Trimester-Specific Thyroid Function in Pregnant Women with Different Iodine Statuses

Trimester-Specific Thyroid Function in Pregnant Women with Different Iodine Statuses

Maternal, cord, and three‐year‐old child serum thyroid hormone concentrations in the Health Outcomes and Measures of the Environment study

Neonatal TSH as a marker of iodine nutrition status. Effect of maternal ioduria and thyroid function on neonatal TSH

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