Effect of maternal and embryonic factors on frozen-thawed IVF-ET outcome after pre-equilibration with hyaluronan

Wang, Weizhou; Ren, Likun; Wei, De-Li; Shen, Yuliang; Liu, Bin; Wang, Xina; Fu, Changhong; Li, Min; Ling, Yan; Feng, Zhichun; Shang, Wei

doi:10.1007/s00404-018-4937-8

Cited by 5 publications

(5 citation statements)

References 45 publications

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“…The effect of age in the fresh cycle on pregnancy outcomes is well-known, whereas domestic and foreign studies of the effect on the pregnancy rate of FETs have shown consistent results [ 17 , 18 ]. A 2011 study [ 2 ] suggested that age is not correlated with the clinical pregnancy rate of FETs as long as there is a sufficient number of high-quality eggs and embryos.…”

Section: Discussionmentioning

confidence: 99%

Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study

Dong

Sun

Huang

et al. 2020

Reprod Biol Endocrinol

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Background With the rapid development of whole embryo freezing technology, more and more frozen-thawed embryo transfer (FET) was used in assisted reproductive technology. However, the best FET program for elderly women has not been finalized. We intended to explore the reproductive outcomes of traditional hormone replacement treatment and a gonadotropin-releasing hormone agonist (GnRHa) combined with hormone replacement treatment in the frozen-thawed embryo transfer cycle of elderly patients. Methods In this retrospective analysis, we analyzed 1264 elderly patients (aged 38 years or older) who underwent FET at three reproductive centers between 2015 and 2017. According to the endometrial preparation protocol, we divided the patients into a GnRHa combined with hormone replacement treatment (GnRHa-HRT) group and traditional hormone replacement treatment (HRT) group. The clinical pregnancy, ongoing pregnancy, live birth, and abortion rates were compared between groups. Results One-way analysis of variance of the two groups revealed no significant difference in the clinical (33.58% vs. 37.15%) and ongoing pregnancy rates (19.40% vs. 25.10%) between the GnRHa-HRT and HRT groups. The live birth rate (17.54% vs. 24.10% p = 0.0229) of the GnRHa-HRT group was lower than that of the HRT group, whereas the abortion rate (45.56% vs. 32.97% p = 0.0252) was higher than that of the HRT group. However, multivariate analysis showed no significant difference in the live birth rate ( p = 0.1333) or abortion rate ( p = 0.1881) between the GnRHa-HRT and HRT groups. The number of embryos transferred, level of the embryo, and age and ovarian reserve of the patient significantly affected final reproductive outcomes. Conclusion A GnRH agonist combined with hormone replacement therapy did not improve the reproductive outcomes of frozen-thawed embryo cycles in elderly patients.

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Section: Discussionmentioning

confidence: 99%

Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study

Dong

Sun

Huang

et al. 2020

Reprod Biol Endocrinol

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“…Embryo implantation preparation needs substantial modification of the uterine microenvironment involving an arranged coevality of complicated interactions between a viable, well-developed embryo and the hormone-dependent, receptive endometrium. Theoretically, implantation can fail due to an inappropriate embryonic function required for implantation, possibly also due to genetic inability and unsuitable uterine receptivity [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Albumin is a source of energy, hormones, vitamins, and metals found in abundance in the female reproductive tract. Furthermore, albumin not only adds viscosity to the culture media but also works as a lubricant, making the embryo easier to handle and preventing embryo adhesion to the culture plate [ 4 , 5 ]. Serum albumin is extracted from the blood; it is an impure substance.…”

Section: Discussionmentioning

confidence: 99%

“…There are some findings related to the beneficial effect of hyaluronan. It was proved beneficial for in-vitro embryo development and implantation for the first time in a mouse [ 3 , 4 ]. It is a linear polysaccharide chain of D-glucuronic acid and N-acetyl-D- glucosamine residues.…”

Section: Introductionmentioning

confidence: 99%

“…It is a linear polysaccharide chain of D-glucuronic acid and N-acetyl-D- glucosamine residues. [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hyaluronic Acid-Enriched Media in Embryo Implantation

Karadbhajne¹,

More²

2022

Cureus

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EmbryoGlue (Vitrolife, Sweden) is a hyaluronan-rich medium manufactured specifically for embryo transfer. Normally, culture media is used for embryo transfer. Culture media is enriched with albumin. Embryo transfer success depends upon the implantation rate. According to some researchers, hyaluronic acid-enriched media may be responsible for the success of embryo transfers. The aim of the study is to check the efficacy of hyaluronic acid-enriched media for previous in-vitro fertilization (IVF) failure patients. A 48year patient was unable to conceive naturally for 20 years. The patient was enrolled for an IVF cycle at Wardha Test Tube Baby Centre in November 2020. The patient was enrolled for three IVF cycles. She was counseled for IVF treatment after failure of three intrauterine inseminations (IUI). Due to menopause, the patient was suggested for IVF with a donor egg and husband's sperm. The uterine septum was found in hysteroscopy and a septum section was done. The patient was conceived after the sixth embryo transfer by using EmbryoGlue. The case report highlighted that the pregnancy may be achieved by the use of EmbryoGlue for embryo transfer.

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Hyaluronic acid–enriched transfer medium for frozen embryo transfer: a randomized, double-blind, controlled trial

Yung

Lai

Lam

et al. 2021

Fertility and Sterility

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Effect of maternal and embryonic factors on frozen-thawed IVF-ET outcome after pre-equilibration with hyaluronan

Cited by 5 publications

References 45 publications

Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study

Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study

Effect of Hyaluronic Acid-Enriched Media in Embryo Implantation

Hyaluronic acid–enriched transfer medium for frozen embryo transfer: a randomized, double-blind, controlled trial

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