Effect of Maternal Age on the Risk of Preterm Birth: A Large Cohort Study

Fuchs, Florent; Monet, Barbara; Ducruet, Thiérry; Chaillet, Nils; Audibert, François

doi:10.1097/01.ogx.0000541308.53092.4a

Cited by 26 publications

(14 citation statements)

References 16 publications

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“…In our study, from the statistical results of chronic medical complications of pregnancy, it could be concluded that the incidence of the pregnant women after age 30 had significant increased in medical history of adverse pregnancy, pregnancy by ART, uterine leiomyoma and thyroid dysfunction. The incidences of chronic hypertension and DM in advanced maternal age increased obviously, which also consistent with the previous researches (14,15). Furthermore, with the development of our social economy and childbearing policy adjustment, advanced maternal women presented with a sharp rise in recent times.…”

Section: Discussionsupporting

confidence: 90%

The changing situation about maternal age, risk factors and pregnancy outcomes after the two-child policy: a retrospective cohort study

Teng

Shane

2020

Ann Palliat Med

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Background: To evaluate the relationship between gestational age, risk factors, pregnancy outcomes, and the causes and trends of the changes in the incidence of pregnancy in different years after the two-child policy. Methods:The study enrolled all of the childbirth women (n=7,016) from January 1st, 2015 to December 31th, 2017 in the Zhujiang Hospital. According to the age of all childbirth women, they were divided into four groups: ≤24, 25-29, 30-34 and ≥35 years old. While 20-29 years old group regarded as the control group (OR =1). Pregnancy complications and outcomes data of 4 groups were collected. χ 2 test and binarylogistic regression used as the analyze method. Stratified chi-square used to compare the rates between the pregnancy risk factors, childbirth modes and pregnancy outcomes in different years, which may be affected by the age.Results: Compared with the other groups, women in ≥35 years old showed the highest incidences of chronic medical complications and pregnancy induced complications, so as the abnormal neonatal birth outcomes. While women in ≤24 years old displayed a high risk of preeclampsia. After the childbearing policy change, the maternal age ratio increased year by year. The incidences of various risk factors, delivery modes and adverse pregnancy outcomes were also changed between different years and different age groups. The differences of annual incidence showed a statistical significance besides oligohydramnios. Conclusions:The study indicated that the changes in childbearing policy lead to the changes of age distribution proportion, which finally caused the changes of risk factors incidence. Furthermore, the advance of medical technology and society also affected the changes of pregnancy risk factors, delivery modes and the pregnancy outcomes in different years.

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Section: Discussionsupporting

confidence: 90%

The changing situation about maternal age, risk factors and pregnancy outcomes after the two-child policy: a retrospective cohort study

Teng

Shane

2020

Ann Palliat Med

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“…Indicators of excess weight in terms of BMI or during pregnancy weight gain especially coupled to older pregnancy age correlated well with higher preterm risk. These last factors have been identified in other investigations [21,22] as risk factors for PTB. It is noteworthy that besides the social status, the high incidence of hemorrhage in this group of women was relatively high.…”

Section: Discussionsupporting

confidence: 53%

Nomogram to Early Screen Multiparous Women for Preterm Birth in a Cohort Study

Traboulsi

Talibi

Boussaid

2021

International Journal of Biology and Biomedical Engineering

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Preterm Birth (PTB) can negatively affect the health of mothers as well as infants. Prediction of this gynecological complication remains difficult especially in Middle and Low-Income countries because of limited access to specific tests and data collection scarcity. Machine learning methods have been used to predict PTB but the low prevalence of this pregnancy complication led to rather low prediction values. The objective of this study was to produce a nomogram based on improved prediction for low prevalence PTB using up sampling and lasso penalized regression. We used data from a cohort study in Northern Lebanon of 922 multiparous presenting a PTB prevalence of 8%. We analyzed the personal, demographic, and health indicators available for this group of women. The improved Positive Predictive Value for PTB reached around 88%. The regression coefficients of the 6 selected variables (Pre-hemorrhage, Social status, Residence, Age, BMI, and Weight gain) were used to create a nomogram to screen multiparous women for PTB risk. The nomogram based on readily available indicators for multiparous women reasonably predicted most of the at PTB risk women. The physicians can use this tool to screen for women at high risk for spontaneous preterm birth to improve medical surveillance that can reduce PTB incidence.

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“…We identified a set of determinants of PTB based on previous literature which were fitted systematically as potential confounders in the multivariable statistical models. They included maternal age (Fuchs et al 2018), sex of the baby (Peelen et al 2016), family's socioeconomic status (high vs. low or medium parental education and occupation) (Joseph et al 2014), maternal smoking during pregnancy (Jaakkola and Gissler 2004), maternal exposure to environmental tobacco smoke during pregnancy (Windham et al 2000) and single parenthood (Zeitlin et al 2002). We also considered other air pollutants as potential confounders when assessing the effect of one pollutant.…”

Section: Covariatesmentioning

confidence: 99%

Synergistic effects of prenatal exposure to fine particulate matter (PM2.5) and ozone (O3) on the risk of preterm birth: A population-based cohort study

Siddika

Rantala

Antikainen

et al. 2019

Environmental Research

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BACKGROUND:There is some evidence that prenatal exposure to low-level air pollution increases the risk of preterm birth (PTB), but little is known about synergistic effects of different pollutants. OBJECTIVES:We assessed the independent and joint effects of prenatal exposure to air pollution during the entire duration of pregnancy. METHODS:The study population consisted of the 2,568 members of the Espoo Cohort Study, born between 1984 and 1990, and living in the City of Espoo, Finland. We assessed individual-level prenatal exposure to ambient air pollutants of interest at all the residential addresses from conception to birth. The pollutant concentrations were estimated both by using regional-to-city-scale dispersion modelling and land-use regression-based method. We applied Poisson regression analysis to estimate the adjusted risk ratios (RRs) with their 95% confidence intervals (CI) by comparing the risk of PTB among babies with the highest quartile (Q4) of exposure during the entire duration of pregnancy with those with the lower exposure quartiles (Q1-Q3). We adjusted for season of birth, maternal age, sex of the baby, family's socioeconomic status, maternal smoking during pregnancy, maternal exposure to environmental tobacco smoke during pregnancy, single parenthood, and exposure to other air pollutants (only in multi-pollutant models) in the analysis. RESULTS:In a multi-pollutant model estimating the effects of exposure during entire pregnancy, the adjusted RR was 1.37 (95% CI: 0.85, 2.23) for PM2.5 and 1.64 (95% CI: 1.15, 2.35) for O3. The joint effect of PM2.5 and O3 was substantially higher, an adjusted RR of 3.63 (95% CI: 2.16, 6.10), than what would have been expected from their independent effects (0.99 for PM2.5 and 1.34 for O3). The relative risk due to interaction (RERI) was 2.30 (95% CI: 0.95, 4.57). DISCUSSION:Our results strengthen the evidence that exposure to fairly low-level air pollution during pregnancy increases the risk of PTB. We provide novel observations indicating that individual air pollutants such as PM2.5 and O3 may act synergistically potentiating each other's adverse effects.

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Effect of Maternal Age on the Risk of Preterm Birth: A Large Cohort Study

Cited by 26 publications

References 16 publications

The changing situation about maternal age, risk factors and pregnancy outcomes after the two-child policy: a retrospective cohort study

The changing situation about maternal age, risk factors and pregnancy outcomes after the two-child policy: a retrospective cohort study

Nomogram to Early Screen Multiparous Women for Preterm Birth in a Cohort Study

Synergistic effects of prenatal exposure to fine particulate matter (PM2.5) and ozone (O3) on the risk of preterm birth: A population-based cohort study

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