Effect of maternal age on spontaneous abortion during the first trimester in Northeast China

Dai, Rulin; Li, Linlin; Zhu, Haibo; Geng, Dongfeng; Deng, Shu

doi:10.1080/14767058.2017.1330330

Cited by 25 publications

(18 citation statements)

References 27 publications

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“…Chromosome abnormalities usually result in developmental arrest and spontaneous abortion. Our laboratory historically [28] used FISH technology for testing chorionic villi, and found that the kinds of fetal abnormalities, numbers of abortions, and chromosomal abnormality rates increased with increasing maternal age, and we hypothesize whether the larger probability of chromosomal abnormalities is due to increased mutation rate with maternal age, or due to a worse in-utero conditions. FISH probes for abortion samples could detect more chromosomal numerical abnormalities for it can detect 16/22 addtionally.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of 4953 pregnant women with indications for genetic amniocentesis in Northeast China

Dai

Yang

et al. 2019

Mol Cytogenet

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BackgroundSeveral different technologies are used for prenatal screening procedures and genetic diagnostic technologies. We aimed to investigate the rates of chromosomal abnormalities in cases with different abnormal prenatal indications and to determine the relationships between fetal chromosomal abnormalities and indicators of prenatal abnormalities in Northeast China.MethodsWe evaluated 4953 16- to 23-week singleton gestation cases using amniocentesis and a total of 3583 participants received serological screening. Fetal chromosomal analyses were performed for all samples using fluorescence in situ hybridization and karyotyping.ResultsAmong these samples, 204 (4.12%) had fetal chromosomal abnormalities. A total of 3583 participants received serological screening, among whom 102 (2.85%) exhibited positive results. A total of 309 participants had ultrasonography; 42 (13.6%) of these had abnormalities. Among 97 participants who had non-invasive prenatal testing (NIPT), 59 (61%) had positive results. Among 1265 participants with advanced maternal age, 78 (6.2%) had abnormal results.ConclusionThe serological screening and NIPT that were included in the prenatal screening methods all had false positive and false negative rates. Although they are both prenatal screening techniques, maternal serum screening cannot be replaced by NIPT. The pregnancy women should accept NIPT in a qualified prenatal diagnostic center. We recommend that pregnant women at high or critical risk undergoing prenatal screening should confirm the fetal karyotype through amniocentesis. Moreover, if women receive a positive result via NIPT, they should not have a pregnancy termination without undergoing further prenatal diagnosis.

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Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of 4953 pregnant women with indications for genetic amniocentesis in Northeast China

Dai

Yang

et al. 2019

Mol Cytogenet

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“…As know, miscarriage is a common pregnancy outcome and more likely to happen among women aged 35 years and older. It is due to fetal abnormalities and chromosomal abnormality linked to mutation by rising maternal age, or worse in-utero conditions [21]. In our setting, this was manifest among Caucasian women.…”

Section: Discussionmentioning

confidence: 73%

Maternal Ethnicity as Risk Factor for Miscarriage: Evidence from a Six-Year Period Cohort in a University Setting

Triunfo¹,

Carlo²,

Cellana³

et al. 2019

Preprint

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In last decades, growing migration flows have modified the obstetric clinical care, requiring specific attention by health care systems. The aim was to describe the phenomenon focusing on miscarriage (pregnancy loss at <20 weeks). Patients admitted for care at miscarriage in a six-year period (2012-17) were revised. Miscarriage rates in all ethnic groups, dichotomized in early (within the first 12 weeks of gestation) and late (at <20 weeks) pregnancy loss. Associations between women's characteristics (age, parity, inter-pregnancy interval (IPI)) were explored to elucidate any differences. A total of 1,940 patients were included, segregated in early (n = 1769, 91.2%) and late (n = 171, 8.8%) pregnancy losses. Caucasian ethnicity was the most common (87.9%), leaving the minority groups to 12.1%. Maternal age was higher among Caucasians women than other subgroups, in contrast to Asiatic patients. Nulliparity was observed in 1045 (53.9%) patient, more widespread among Caucasian and Maghrebins. A positive obstetric history counting at least one miscarriage was frequent, ranging from 22.2% to 75%, in particular among Asiatic women, while the recurrence in Caucasians. In Afro-Carribeans the most relevant rate of late miscarriage was found. By multiple regression modelling, maternal age, nulliparity and Afro-Carribean were identified as determinants. Maternal ethnicity should be considered in the management of pregnancy losses in combination with already well-defined risk factors, including age at miscarriare and nulliparity.

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“…Although female age and BMI are first line prognostic factors in human reproduction, we did not find significant differences between the age or BMI groups with miscarriage. Winter et al (2002) concluded that there was no significant relationship between age, obesity, and the miscarriage rate, while Dai et al . (2018) pointed out that women over the age of 40 had significantly higher early miscarriages rates (60.6%) than women under the age of 40.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI)

Basirat

Kashifard

Golsorkhtabaramiri

et al. 2019

JBRA Assisted Reproduction

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Objective: The aim of this study was to describe the miscarriage rates and the factors associated with cases of spontaneous abortion observed in women offered intracytoplasmic sperm injection (ICSI). Methods: This cross-sectional study enrolled women who became pregnant with the aid of ICSI treated at the Babol Infertility Center (Iran) within a period of five years (2010-2015). Data were collected from patient charts and, in some cases, through phone calls. The study looked into the incidence of spontaneous abortion in women offered ICSI and the factors associated with miscarriage. The chi-square test, Fisher's exact test, and the t-test were used to analyze the data. Results: From a total of 145 pregnant women, 120 were included in our study. The prevalence of miscarriage was 20%. Galactorrhea was significantly more present in patients who had miscarriages (25% vs. 9.37%, p =0.04). There was a marked difference in the duration of infertility of miscarriage and non-miscarriage patients offered ICSI (6.6±8.3 vs. 4.9±7.3 years, p =0.05). No association was found between maternal age, BMI, cause of infertility, hormonal pattern, type of infertility, history of surgery, polycystic ovary syndrome, number of oocytes, or day of retrieval with miscarriage.

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Effect of maternal age on spontaneous abortion during the first trimester in Northeast China

Cited by 25 publications

References 27 publications

Prenatal diagnosis of 4953 pregnant women with indications for genetic amniocentesis in Northeast China

Prenatal diagnosis of 4953 pregnant women with indications for genetic amniocentesis in Northeast China

Maternal Ethnicity as Risk Factor for Miscarriage: Evidence from a Six-Year Period Cohort in a University Setting

Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI)

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