Effect of mastication on regional cerebral blood flow in humans examined by positron-emission tomography with 15O-labelled water and magnetic resonance imaging

Momose, Toshimitsu; Nishikawa, Junko; Watanabe, Takashi; Sasaki, Yasuto; Senda, Michio; Kubota, Kisou; Sato, Yukio; Funakoshi, Mitsuaki; Minakuchi, Shunsuke

doi:10.1016/s0003-9969(96)00081-7

Cited by 202 publications

(147 citation statements)

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“…Chewing causes regional increases in cerebral blood flow and neuronal activity in the human brain (7,8). By contrast, it has been shown that reduced mastication and occlusal disharmony impair spatial memory and promote the degeneration of hippocampal neurons (9,10).…”

Section: Introductionmentioning

confidence: 99%

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Akazawa

Kitamura

Fujihara

et al. 2012

International Journal of Molecular Medicine

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Abstract. In this study, we examined the effect of forced mastication on neurogenesis in the hippocampal dentate gyrus (DG) of adult mice. Six-week-old mice were subjected to either a hard or normal diet for 13 weeks. They received a daily injection of bromodeoxyuridine (BrdU) for 12 consecutive days beginning at 14 weeks of age. The number of BrdU-positive cells in the DG was counted 1 day after and 5 weeks after the final BrdU injection. The number of BrdU-positive cells 1 day after injection did not differ between the 2 diet groups. However, the number of BrdU-positive cells in the group fed the hard diet was significantly increased 5 weeks after BrdU injection compared to the group fed the normal diet. The results of the Morris water maze test showed that mice fed a hard diet required significantly less time to reach the platform than the control mice when tested at 10 days. Moreover, mice in the group fed the hard diet spent significantly more time in the former platform area than the group fed the normal diet, indicating that hard diet feeding improved spatial memory compared to normal diet feeding. Real-time PCR analysis showed that the expression of glutamate receptor 1 mRNA was significantly increased in the group fed the hard diet compared with the group fed the normal diet. These results suggest that mastication increases the survival of adult neural stem cells in the hippocampal DG.

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Section: Introductionmentioning

confidence: 99%

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Akazawa

Kitamura

Fujihara

et al. 2012

International Journal of Molecular Medicine

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“…Although patterns of mastication movement may vary considerably between individuals, chewing becomes well co-ordinated around the age of 4-5. Gum-chewing PET [4] and fMRI [5] experiments in healthy subjects have confirmed significant activations in the oral region of the primary sensorimotor cortex, but have also revealed the involvement of the supplementary motor area, insula, thalamus, and cerebellum. These regions are believed to receive sensory information from the lips, tongue, oral mucosa, gingivae, teeth, mandible, and temporo-mandibular joint and to control the lingual and facial muscles during mastication ( Figure 1).…”

Section: Introductionmentioning

confidence: 83%

Mastication Dyspraxia: A Neurodevelopmental Disorder Reflecting Disruption of the Cerebellocerebral Network Involved in Planned Actions

et al. 2012

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This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent repository link AbstractThis paper reports longitudinal clinical, neurocognitive and neuroradiological findings in an adolescent patient with non-progressive motor and cognitive disturbances consistent with a diagnosis of developmental coordination disorder (DCD). In addition to prototypical DCD, development of mastication was severely impaired while no evidence of swallowing apraxia, dysphagia, sensorimotor disturbances, abnormal tone or impaired general cognition were found. He suffered from bronchopulmonary dysplasia and was ventilated as newborn for 1.5 months. At the age of three months a ventriculoperitoneal shunt was surgically installed because of obstructive hydrocephalus secondary to perinatal intraventricular bleeding. At the age of five, the patient's attempts to masticate were characterized by rough, effortful and laborious biting movements confined to the vertical plane. Solid food particles had a tendency to get struck in his mouth and there was constant spillage. As a substitute for mastication, he moved the unground food with his fingers in a lateral direction to the mandibular and maxillary vestibule to externally manipulate and squeeze the food between cheek and teeth with the palm of his hand. Once the food was sufficiently soft, the bolus was correctly transported by the tongue in posterior direction and normal deglutition took place. Repeat MRI during follow-up disclosed mild structural abnormalities as the sequellae of the perinatal intraventricular bleeding but this could not explain impaired mastication behaviour.Quantified Tc-99m-ECD SPECT, however, revealed decreased perfusion in the left cerebellar hemisphere, as well as in both inferior lateral frontal regions, both motor cortices and the right anterior and lateral temporal areas. Anatomoclinical findings in this patient with DCD not only indicate that the functional integrity of the cerebello-cerebral network is crucially important in the planning and execution of skilled actions, but also seem to show for the first time that mastication deficits may be of true apraxic origin. As a result it is hypothesized that "mastication dyspraxia" may have to be considered as a distinct nosological entity within the group of the developmental dyspraxias following a disruption of the cerebello-cerebral network involved in planned actions.

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“…[55][56][57] Observations documenting the relationship between dental pathologies and aging, including the aging of the hearing organ, are not very surprising. It was suggested that poor dental health might contribute to the development of dementia in senility.…”

Section: Dental Pathologies and Hearingmentioning

confidence: 99%

Hearing and stomatognathic system: Searching for a link

Baliński¹,

Morawska-Kochman²,

Bochnia³

2017

Dent. Med. Probl.

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Acoustic vibrations reach the inner ear fluids in 3 integral ways: through the air, bone, and soft tissue. The final stimulation of the hearing receptor is recognized as the result of various interactions appearing between them. Air conduction is best described as the most efficient mode of auditory stimulation. Soft tissue and bone conduction (including dentaural hearing), being frequently underestimated in the complicated process of hearing, are still less examined. Clinical observations prove that dental health may have a direct influence on hearing. Additionally, hearing improvement after dental treatment is of a permanent nature.This review presents a hypothesis and supporting literature review that dental disorders may contribute to disturbances in the excitation and/or the transmission of vibrations through the bone to the hearing receptor. Dissociation in the relationship between stimuli reaching the cochlea simultaneously in 3 modes may have a negative impact on hearing acuity.

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Effect of mastication on regional cerebral blood flow in humans examined by positron-emission tomography with 15O-labelled water and magnetic resonance imaging

Cited by 202 publications

References 1 publication

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Mastication Dyspraxia: A Neurodevelopmental Disorder Reflecting Disruption of the Cerebellocerebral Network Involved in Planned Actions

Hearing and stomatognathic system: Searching for a link

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