Effect of mast cells on tumor angiogenesis in lung cancer

Tomita, Masaki; Matsuzaki, Yasunori; Onitsuka, Toshio

doi:10.1016/s0003-4975(00)01160-7

Cited by 103 publications

(77 citation statements)

References 16 publications

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“…These findings were in stark contrast to those which were reported in previous studies which were done on various tumours [21][22][23][24][25].…”

Section: Discussioncontrasting

confidence: 99%

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The Relevance of Mast Cells in Oral Squamous Cell Carcinoma

Cheema¹,

Ramesh²,

Balamurali³

2012

JCDR

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Context:The commonly occurring oral neoplasm -Oral Squamous Cell Carcinoma (OSCC) has an association with the chronic inflammation in the adjacent connective tissue. Mast cells are the local residents of the connective tissue. They are said to be pro inflammatory and immune-amplifying in action and they produce mitogenic cytokines. They exhibit a phenotypic plasticity with a change in the microenvironment, thus making the role of the mast cells in this disease even more intriguing. Mast cells have also been reported to play a role in tumour progression and metastases by promoting angiogenesis.Aims: The present study aimed at comparing the Mast Cell Density (MCD) in the Normal Oral Mucosa (NM) and among the various grades of OSCC and at analyzing the possible role of the mast cells. Settings and Design:The MCD was assessed by using the 1% Toluidine blue stain in a study sample of 102 cases of different grades of OSCC and in 07 cases of clinically normal oral mucosa.Statistical Analysis Used: By using the Student's 't' test and one way ANOVA, the Mast Cell Density (MSD) was found to be significantly higher in well differentiated squamous cell carcinoma and in moderately differentiated squamous cell carcinoma as compared to that in the poorly differentiated oral squamous cell carcinoma (P=< 0.01) which was significant at a 1% level. The Spearman's Rank Correlation Co-efficient revealed a significant correlation between the density of the mast cells and the increasing grade of the OSCC. Conclusions:These findings denote that as the squamous cell carcinoma enters the poorly differentiated state, there may be some change which is reflected as a decrease in the mast cell density.

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“…These findings were in stark contrast to those which were reported in previous studies which were done on various tumours [21][22][23][24][25].…”

Section: Discussioncontrasting

confidence: 99%

“…Consequently, the tumours which have more stroma may have more micro vessels and mast cells. For this reason, the variations in the amount of stroma and the tumour cells may influence the average number of the mast cells [23].…”

Section: Discussionmentioning

confidence: 99%

The Relevance of Mast Cells in Oral Squamous Cell Carcinoma

Cheema¹,

Ramesh²,

Balamurali³

2012

JCDR

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“…Stromal cell-TP expression was correlated with high MVCs and mast cell counts in patients with adenocarcinoma, whereas there were no significant associations of stromal cell-TP expression with MVCs, mast cell counts, or macrophage counts in patients with squamous cell carcinoma. Intratumoral mast cells were correlated with MVCs in patients with NSCLC, 29 and especially in patients with adenocarcinoma. 27,28 Intratumoral mast cell accumulation was found in the tumor cell-VEGF positive tumor group in patients with adenocarcinoma of the lung.…”

Section: Discussionmentioning

confidence: 96%

“…25 Angiogenic factors, including TP, stimulate mast cell migration in vitro. 26 Recent investigations [27][28][29] have demonstrated that mast cell accumulation is associated with tumor angiogenesis and poor outcome in patients with NSCLC, and especially in patients with adenocarcinoma of the lung. Vascular endothelial growth factor (VEGF) expression in tumor cells is associated with increased MVCs and a poor prognosis in patients with NSCLC, supporting the role VEGF as a mitogenic growth factor that is selective for vascular endothelial cells and as an important prognostic factor.…”

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confidence: 99%

Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma

Kojima

Shijubo

Abe

2002

Cancer

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Sleeping giants: As a mimic of cell agglomeration to form tissues, a novel vesicle aggregation process with the characteristic advantages of being highly efficient, light‐responsive, reversible, large‐scale, and stable is reported. Giant hyperbranched polymer vesicles (5–10 μm) are used as the building blocks (see scheme), and the vesicle aggregates can assemble and disassemble with alternating UV and Vis irradiation.

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“…released from them have been implicated in promoting angiogenesis. Hence, accumulation of mast cells appears to potentiate vessel growth [3,4].Studies have shown that OSCC is associated with chronic inflammation, immune reaction and angiogenesis with the progression of dysplastic changes. Hence, there is a need to assess the role of mast cells in OSCC [1][2][3].Our study was carried out to compare mast cell density in normal mucosa and squamous cell carcinoma and to assess the role of mast cells in oral squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Assessment of role of mast cells in oral squamous cell carcinoma

Gaddikeri¹,

Bhorgonde²

2016

APJHS

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Background: Mat cells play a crucial role in homeostasis and inflammation. Recently mast cells have been associated with numerous malignancies like oral squamous cell carcinoma (OSCC).Aims and Objectives: To compare mast cell density in normal mucosa and squamous cell carcinoma and to assess the role of mast cells in oral squamous cell carcinoma.Materials and Methods: Our retrospective study included 40 specimens, 10 well differentiated OSCC, 10 moderately differentiated OSCC, 10 poorly differentiated OSCC and 10 controls. Mast cell density was determined by toluidine blue staining. Statistical analysis was carried out using Statistical Package for Social Sciences (SPSS) 17.0 version (SPSS Inc., Chicago, IL, USA).Results: When compared with controls, mast cells count was a higher in OSCC groups which was a statistically significant (P < 0.001). Conclusion: Mast cells have a significant role in OSCC.

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Effect of mast cells on tumor angiogenesis in lung cancer

Cited by 103 publications

References 16 publications

The Relevance of Mast Cells in Oral Squamous Cell Carcinoma

The Relevance of Mast Cells in Oral Squamous Cell Carcinoma

Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma

Assessment of role of mast cells in oral squamous cell carcinoma

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