Effect of Marijuana Smoking on Blood Chemistry and Serum Biogenic Amines Concentrations in Humans

Ebuehi, Oat; Akinwande, A. I.; Oo, Famuyiwa; Uzodinma, EO; Adebayo, OA; Onwumere, OA; Masade, ON; Aiyesimoju, B

doi:10.4314/njhbs.v4i1.11532

Cited by 7 publications

(6 citation statements)

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“…It is suggested that tricyclic drugs could reverse HVS in a physiological way through their improvement in brain serotonin and then subsequently be discontinued [31]. Ebuehi previously reported that malnutrition, marijuana smoking and ethanol consumption all decreased serotonin in experimental animals [32][33][34], while the tricyclic drugs (Impramine or amitriptyline) produces a more pronounced increase in brain serotonin levels compared with antidepressants such as sertraline [35]. These observations suggest that serotonin is important in the condition of HVS and offers a possible explanation for the observed benefits of amitriptyline.…”

Section: Discussionmentioning

confidence: 99%

The beneficial effects of oral amitriptyline in anxiety-induced hyperventilation syndrome; a case series

Varney¹,

Parnell²,

Quirke³

2016

Clin Case Rep Rev

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We describe 12 breathless patients all referred to respiratory outpatients where a final diagnosis of anxiety-induced chronic hyperventilation syndrome was made. Many had received treatments for asthma or COPD or cardiac disease without benefit and had attended their GP and A&E departments repeatedly without a clear diagnosis being made; despite raised oxygen saturations and respiratory rate at rest. Referrals to rapid access chest pain clinics were also common leading to multiple other investigations with yet further patient anxiety and prolonged periods away from work.The cases show that a clear diagnosis could have been made at the outset by a careful history particularly recognizing the circumstances at the onset of the condition, along with the presence of significant insomnia and anxiety-like symptoms with admission to panic if enquiries made.All cases responded promptly to oral amitriptyline that was commenced at 10 mg nocte and increased until full sleep was restored and hyperventilation ceased.In this case series we review the topic of anxiety-induced hyperventilation and discuss data suggesting that carbon-dioxide sensitivity in the brain-stem (respiratory centre) changes during slow wave sleep. Serotonergic neurons influence this, causing respiratory depression and tricyclic drugs enhance the activity of these neurons and are described to alleviate symptomatic hyperventilation by restoring slow wave sleep. This would be a reasonable treatment trial for doctors to commence in patients with insomnia and a picture of hyperventilation. It would be expected to give clinical improvement once the dose restores sleep, confirming the likely diagnosis and avoiding time away from work with protracted symptoms and possibly unwarranted investigations and referrals.

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Section: Discussionmentioning

confidence: 99%

The beneficial effects of oral amitriptyline in anxiety-induced hyperventilation syndrome; a case series

Varney¹,

Parnell²,

Quirke³

2016

Clin Case Rep Rev

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“…The plasma dopamine level was assayed by High Performance Liquid Chromatography [4], while the electrolytes levels determined flame photometry [6]. The lipid profile was determined using diagnostic Randox kits and hematology by auto -analyzer [7].…”

Section: Methodsmentioning

confidence: 99%

“…THC has some therapeutic effect which includes alleviating nausea and vomiting, but smoking of marijuana could lead to dizziness, tachycardia tremor, transient muscular rigidity and disoriented [3]. Marijuana smoking have been reported to significantly affect the blood chemistry and may also affect neural functions [4].…”

Section: Introductionmentioning

confidence: 99%

Smoking Effects of Marijuana and Cigarette on Blood Chemistry, Hematology and Plasma Dopamine Levels in Young Adults

Ebuehi

Ukwade

Adegbola

2018

AJMAH

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Aim:Smoking is an increasing problem in public health world-wide. Smoke from marijuana and cigarette have been shown to contain many toxins. This study investigated the effect of marijuana and cigarette smoking on hematology, blood chemistry and plasma dopamine level of smokers in comparison to non-smokers. Materials and Methods: Blood samples were taken from thirty randomly selected Nigerian male and female non-smokers (control) and thirty smokers each. Analytical biochemical procedures and standard Randox diagnostic kits were used to determine the blood chemistry, hematology, electrolytes and plasma dopamine level of smokers and non-smokers. Results: The completely randomized design study revealed no significant (p>0.05) difference in the blood chemistry, hematological parameters, electrolytes and plasma dopamine levels between the test and control subjects. Though within normal range, the values observed for total leucocytes were marginally higher in the cigarette smoking test subjects, while marginally lower in marijuana smoking Original Research Article

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“…These findings are also confirmed by already reported assumptions. 56,57,27,58,59 This implies that tobacco smoking stresses vital physiological mechanisms and puts the body the body on elevated risk of insectcide toxicity. …”

Section: Discussionmentioning

confidence: 99%

Chemical Biomarker Study of Negative Physiological Effects of Insecticides on Pakistani Farm Workers Health in the Central Punjab

Shahzad¹,

Yaqub²,

Shaukat³

et al. 2016

Annals KEMU

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Background: In recent decades, use of pesticides in agricultural practices has posed threat to human population. Objectives: Present research was designed to explore the adverse effects of insecticides on 339 individuals (study group farmers n = 256 and control n = 83) selected from 62 different sites of central Punjab. The sample was matched on socio-economic status and age. Methodology: A structured questionnaire was used to

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Effect of Marijuana Smoking on Blood Chemistry and Serum Biogenic Amines Concentrations in Humans

Cited by 7 publications

References 0 publications

The beneficial effects of oral amitriptyline in anxiety-induced hyperventilation syndrome; a case series

The beneficial effects of oral amitriptyline in anxiety-induced hyperventilation syndrome; a case series

Smoking Effects of Marijuana and Cigarette on Blood Chemistry, Hematology and Plasma Dopamine Levels in Young Adults

Chemical Biomarker Study of Negative Physiological Effects of Insecticides on Pakistani Farm Workers Health in the Central Punjab

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