Effect of Marihuana on Intraocular and Blood Pressure in Glaucoma

Merritt, John C.; Crawford, William; Alexander, Paul C.; Anduze, Alfred; Gelbart, Solomon S.

doi:10.1016/s0161-6420(80)35258-5

Cited by 126 publications

(68 citation statements)

References 12 publications

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“…Namely, the only approved medical indications correctly identifi ed by more than 50% of pharmacy students were for the treatment of cancer and glaucoma (91% and 57%, respectively). Beside this two, therapeutic uses of medical marijuana are shown in many other diseases and conditions such as spastic disorders, pain, bronchial asthma, nausea and vomiting caused by anticancer drugs, mood disorders, anorexia, epilepsy and glaucoma [18][19][20][21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Stojanović¹,

Tomas²,

Paut-Kusturica³

et al. 2017

Hosp Pharm Int Multi J

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SUMMARYIntroduction: With the growing trend for legalization of cannabis and its derivatives in Serbia, pharmacists are likely to be consulted on the safety, effi cacy, and drug-drug or drug-disease interactions of medical cannabis. Thus, the aim of our study was to assess pharmacy students' knowledge and attitude toward medical cannabis use in Serbia to determine if additional education is needed. Subjects and methods: In the study students from the fi nal year of the study program of integrated academic studies of pharmacy at the Faculty of Medicine, University of Novi Sad were asked to complete an anonymous questionnaire regarding their knowledge and attitudes on the use of cannabis and its derivatives in medical purposes. After giving their written informed consent, they were instructed by the researchers on how to complete the questionnaire. All questionnaires were administered between August 1, 2017 and August 15, 2017. The study was approved by the Ethical Committee of the Faculty of Medicine in Novi Sad; a total of 80 questionnaires were distributed. The questionnaire consisted of 3 groups of statements on which they should mark level of their agreement related to students' knowledge about the use of cannabis and its derivatives in therapeutical purposes, potential negative eff ects, dispensing in a pharmacy and legalization of cannabis and its derivatives in medical purposes. Results: Although 91.2% of the respondents agreed that cannabis and its derivatives could potentially have therapeutical eff ects, much lower percentage of respondents (51.3%) were familiar with possible therapeutical eff ects of cannabis. The same percentage of respondents learned about therapeutical eff ects of cannabis from sources other than school. About third (31.3%) of our respondents thought that the use of cannabis and its derivatives in therapeutical purposes could cause their abuse and the similar percentage of respondents (33.8%) thought that issuing cannabis and its derivatives in the pharmacy could expose a pharmacist to the certain dangers such as insisting on the issuing without the prescription or robbery. About 90% of the respondents agreed it is necessary to create clear guidelines for the use of cannabis and its derivatives in therapeutical purposes and 76.3% of the respondents thought that doctor's prescription is necessary for their dispensing in a pharmacy. Most of the respondents (75%) agreed that, based on the experiences of the countries which have

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Section: Discussionmentioning

confidence: 99%

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Stojanović¹,

Tomas²,

Paut-Kusturica³

et al. 2017

Hosp Pharm Int Multi J

View full text Add to dashboard Cite

show abstract

“…THC or marijuana decreased intraocular pressure whether administered orally, topically, or intravenously, with no major tolerance to their effect reported (Shapiro, 1974;Purnell and Gregg, 1975;Cuendet et al, 1976;Hepler et al, 1976;Brown et al, 1977;Merritt et al, 1980Merritt et al, , 1981a. Most of these studies also reported various systemic side effects, such as hypotension, tachycardia, euphoria, and dysphoria, as well as other ocular effects, such as changes in pupil size, decreased tear production, and conjunctival hyperemia.…”

Section: E Eye Disorders (Glaucoma and Retinopathy)mentioning

confidence: 99%

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

2006

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“…[242][243][244] Marijuana smoking was shown to reduce IOP as early as 1971; the effect was later confirmed. [245][246][247][248] The peak effect of THC on the central nervous system coincided well with the reduction in intraocular pressure induced by the drug; However, hypotonia outlasted euphoria. The results indicate that THC may have value as a hypotonizing ocular drug.…”

Section: Asthma Cardiovascular Disorders Glaucomamentioning

confidence: 72%

Cannabinoids in Health and Disease

2016

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annabis sativa L. preparations, such as marijuana, hashish, and dagga, have been used in medicine for millenia.1 Investigations into the chemistry of Cannabis began in the mid-19th century, following a major trend in chemical research at the time, which centered on the quest for active natural products. Numerous alkaloids were isolated in pure form from various plants, and many of them were fully or partially characterized. Morphine, cocaine, strychnine, and many others were purified and used in medicine. However, most of the terpenoids-a major class of secondary plant metabolites, to which the plant cannabinoids also belong-were not isolated until the end of the century or even much later, and in many cases their purity was doubtful. 413C l i n i c a l r e s e a r c h

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Effect of Marihuana on Intraocular and Blood Pressure in Glaucoma

Cited by 126 publications

References 12 publications

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Cannabinoids in Health and Disease

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