Effect of Marek’s disease vaccines on interferon and toll like receptors when administered in ovo

Gimeno, Isabel M.; Glaize, Ayanna; Cortes, Aneg L.

doi:10.1016/j.vetimm.2018.05.012

Cited by 10 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marek's disease vaccination in ovo (with herpesvirus of turkey, or attenuated MDV strains SB-1 or CVI988) has been shown to accelerate immune system maturation and increase the proportions of T cell subsets in the spleen (Gimeno et al, 2015). Additionally, depending on the strain used, Marek's disease vaccination in ovo can induce the expression of type I IFNs and TLRs in lymphoid tissues (Gimeno et al, 2018). Furthermore, in ovo vaccination of chicken embryos (ED18) with herpesvirus of turkeys resulted in higher NK cell activity than in chicks vaccinated at hatch (Sharma et al, 1984).…”

Section: Innate Immunity and In Ovo Vaccination: Perspectivesmentioning

confidence: 99%

Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective

et al. 2019

View full text Add to dashboard Cite

Newly hatched chickens are confronted by a wide array of pathogenic microbes because their adaptive immune defences have limited capabilities to control these pathogens. In such circumstances, and within this age group, innate responses provide a degree of protection. Moreover, as the adaptive immune system is relatively naïve to foreign antigens, synergy with innate defences is critical. This review presents knowledge on the ontogeny of innate immunity in chickens pre-hatch and early post-hatch and provides insights into possible interventions to modulate innate responses early in the life of the bird. As in other vertebrate species, the chicken innate immune system which include cellular mediators, cytokine and chemokine repertoires and molecules involved in antigen detection, develop early in life. Comparison of innate immune systems in newly hatched chickens and mature birds has revealed differences in magnitude and quality, but responses in younger chickens can be boosted using innate immune system modulators. Functional expression of pattern recognition receptors and several defence molecules by innate immune system cells of embryos and newly hatched chicks suggests that innate responses can be modulated at this stage of development to combat pathogens. Improved understanding of innate immune system ontogeny and functionality in chickens is critical for the implementation of sound and safe interventions to provide long-term protection against pathogens. Next-generation tools for studying genetic and epigenetic regulation of genes, functional metagenomics and gene knockouts can be used in the future to explore and dissect the contributions of signalling pathways of innate immunity and to devise more efficacious disease control strategies.

show abstract

Section: Innate Immunity and In Ovo Vaccination: Perspectivesmentioning

confidence: 99%

Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective

et al. 2019

View full text Add to dashboard Cite

show abstract

“…7 Received a 50 µL solution volume of the Marek's disease vaccine injected at 18 doi. 8 Embryos injected with the Marek's disease vaccine containing 1.2 µg of 25OHD 3 . 9 Embryos injected with the Marek's disease vaccine containing 2.4 µg of 25OHD 3 .…”

Section: Hatch Variablesmentioning

confidence: 99%

“…In ovo injection is used for the direct administration of particular nutrients or vaccines in the amnion of embryos between 17.5 and 19.25 d of incubation (doi) [2][3][4]. Furthermore, the 18 doi in ovo administration of several vaccines for Escherichia Coli [5], Mycoplasma galicepticum [6], infectious bursa disease [7] and Marek's disease [8] and various supplemental nutrients including vitamins, minerals, and carbohydrates [1,2,[9][10][11] have been shown to promote not only hatchling immunity but also to improve hatchability and posthatch performance. Although the use of various vaccine has been well established in US broiler hatcheries, the use of any nutrients including vitamins minerals, proteins, amino acids, and organic acids has not been commercially used.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of the Marek’s Disease Vaccine on the Performance, Meat Yield, and Incidence of Woody Breast Myopathy in Ross 708 Broilers When Administered Alone or in Conjunction with In ovo and Dietary Supplemental 25-Hydroxycholecalciferol

Fatemi,

Mousstaaid,

Williams

et al. 2024

Animals

View full text Add to dashboard Cite

The effects of the Marek’s disease vaccine (MDV) on the live performance, breast meat yield, and incidence of woody breast myopathy (WBM) of Ross 708 broilers were investigated when administered alone or in conjunction with in ovo and dietary supplemental 25-hydroxycholecalciferol (25OHD3). At 18 d of incubation (doi), four in ovo injection treatments were randomly assigned to live embryonated Ross 708 broiler hatching eggs: (1) non-injected; (2) commercial MDV alone; or MDV containing either (3) 1.2 or (4) 2.4 μg of 25OHD3. An Inovoject multi-egg injector was used to inject a 50 μL solution volume into each egg. The birds were provided a commercial diet that contained 250 IU of cholecalciferol/kg of feed (control) or a commercial diet that was supplemented with an additional 2760 IU of 25OHD3/kg of feed (HyD-diet). In the growout period, 14 male broilers were placed in each of 48 floor pens resulting 6 replicated pens per in ovo x dietary treatment combination. Live performance variable were measured at each dietary phases from 0 to 14, 15 to 28, and 29 to 40 d of age (doa). At 14 and 40 doa, pectoralis major (P. major) and pectoralis minor (P. minor) muscles were determined for one bird within each of the six replicate pens. At 41 doa, WBM incidence was determined. No significant main or interaction effects occurred for WBM among the dietary or in ovo injection treatments. However, in response to in ovo 25OHD3 supplementation, BW and BWG in the 29 to 40 doa period and BWG and FCR in the 0 to 40 doa period improved. In addition, at 40 and 41 doa, breast meat yield increased in response to in ovo and dietary 25OHD3 supplementation. Future research is needed to determine the possible reasons that may have been involved in the aforementioned improvements.

show abstract

“…However, among the aforementioned in ovo vaccines, the MD vaccine (MDV) that is most commonly used in US hatcheries contains HVT alone, as the backbone virus in association with the MD virus, or as a combinatorial recombinant vaccine such as HVT-IBD, HVT-ND, and HVT-ILT [5]. It has been reported that in ovo injection of the MDV at 18 days of incubation (doi) results in an approximate 90% level of immune protection [4], an improvement in intestinal histomorphology [6], and an increase in the expression of genes associated with humoral immunity [7] in early post-hatch broilers.…”

Section: Introductionmentioning

confidence: 99%

Vitamin Compatibility with the Marek’s Disease Vaccine

Fatemi,

Williams,

Deines

et al. 2023

Poultry

View full text Add to dashboard Cite

In ovo injection of the Marek’s disease (MD) vaccine (MDV) has been widely practiced in commercial US hatcheries. However, the MDV is very sensitive and may not be compatible with some nutrients when administered together by in ovo injection. When individually administered by in ovo injection, L-Ascorbic acid (L-AA) and 25-hydroxyvitamin D3 (25OHD3) have previously exhibited very promising results on the post-hatch physiological and immunological characteristics of broilers subjected to stressful commercial conditions. However, the compatibility of the MDV with these vitamins has not been previously explored. Their compatibility must first be established before their combined administration by in ovo injection can be considered. Therefore, the objective in this study was to determine the compatibility of the MDV with various levels of 25OHD3 or L-AA. The treatments employed were MDV-alone, MDV in combination with 0.6 (low) or 2.4 (high) μg doses of 25OHD3, or MDV in combination with 1.2 (low) or 12 (high) mg doses of L-AA. The live and dead ratio of primary chick embryo fibroblast cells infected by the MD virus (CEF-MDV) in each treatment was determined every 30 min for 2 h. The L-AA at both the low and high doses resulted in a 70% death of CEF-MDV within 1 h, but either dose of the 25OHD3 exhibited only an approximate 5% lower CEF-MDV survival as compared to those in the MDV-alone treatment. Therefore, it is suggested that the two designated doses of 25OHD3 have the potential to be effectively combined with the MDV for subsequent administration by in ovo injection.

show abstract

Effect of Marek’s disease vaccines on interferon and toll like receptors when administered in ovo

Cited by 10 publications

References 33 publications

Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective

Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective

Effects of the Marek’s Disease Vaccine on the Performance, Meat Yield, and Incidence of Woody Breast Myopathy in Ross 708 Broilers When Administered Alone or in Conjunction with In ovo and Dietary Supplemental 25-Hydroxycholecalciferol

Vitamin Compatibility with the Marek’s Disease Vaccine

Contact Info

Product

Resources

About