Effect of Marathon Run and Air Travel on Pre- and Post-Run Soluble D-Dimer, Microparticle Procoagulant Activity, and P-Selectin Levels

Changes in Endothelial Markers during a Summer Ultra-Endurance Road Cycling Event in the Heat

“…It has been suggested that age is associated with greater concentrations of p-selectin immediately following prolonged endurance exercise events [13]. The 28% increase in p-selectin concentrations from PRE to IP observed in the present study supports previous findings of exercise-induced activation of the endothelium [13,27], and adds to these findings by demonstrating that this activation is also present after prolonged cycling in the heat. However, unlike Parker et al [13], we found no relationship between changes in p-selectin and changes in age of the riders in our study.…”

“…The 28% increase in p-selectin concentrations from PRE to IP observed in the present study supports previous findings of exercise-induced activation of the endothelium [13,27], and adds to these findings by demonstrating that this activation is also present after prolonged cycling in the heat. However, unlike Parker et al [13], we found no relationship between changes in p-selectin and changes in age of the riders in our study. Nor did we find a correlation between changes in core temperature and p-selectin.…”

“…One of these parameters is p-selectin, which is primarily located in endothelium cells and storage granules in platelets and translocated to the cell surface upon activation of the endothelium [24]. The concentrations of p-selectin is increased in individuals with various immunological, inflammatory, and cardiovascular disease ( [25,26] and increases after high intensity exercise [13,27]. It has been suggested that age is associated with greater concentrations of p-selectin immediately following prolonged endurance exercise events [13].…”

“…The concentrations of p-selectin is increased in individuals with various immunological, inflammatory, and cardiovascular disease ( [25,26] and increases after high intensity exercise [13,27]. It has been suggested that age is associated with greater concentrations of p-selectin immediately following prolonged endurance exercise events [13]. The 28% increase in p-selectin concentrations from PRE to IP observed in the present study supports previous findings of exercise-induced activation of the endothelium [13,27], and adds to these findings by demonstrating that this activation is also present after prolonged cycling in the heat.…”

An update on the Boston Marathon as a research laboratory

“…P-selectin is a biomarker associated with inflammation and an increased risk of ASCVD. We had shown in participants in the 2010 BAA [21] that p-selectin increases with marathon running. We speculated that this increase could contribute to the known acute increase in ASCVD risk with exercise.…”