Effect of Manuka Honey on Eyelid Wound Healing: A Randomized Controlled Trial

Malhotra, Raman; Ziahosseini, Kimia; Poitelea, Cornelia; Litwin, Andre; Sagili, Suresh

doi:10.1097/iop.0000000000000743

Cited by 20 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, this study coincides with the findings of Boroumand et al [9], which showed that honey has analgesic effect after tonsillectomy. Malhotra et al [21] indicated to the early postsurgical benefits of honey application on eyelid wounds, which somewhat agrees with the results of the current study; VAS scores of Manuka side was significantly lower only in the first and second postoperative days.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Effect of Intrasocket Application of Manuka Honey on Postsurgical Pain of Impacted Mandibular Third Molars Surgery: Split-Mouth Randomized Controlled Trial

Al‐Khanati

Al-moudallal

2018

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

Background and Purpose Sufficient evidence exists recommending the use of honey in the management of wounds. Studies revealed that the healing effect of honey could be classified by its antibacterial and anti-inflammatory properties of its components. Since surgical extraction of impacted molars is one of the most common operations in the oral cavity and the postoperative pain disturbing the patient may reduce the quality of health service, this study aimed to assess the analgesic potential of Manuka honey application into the extraction socket of impacted mandibular third molars. Methods This randomized split-mouth controlled study included 33 patients undergoing impacted bilateral lower third molars surgery under local anesthesia (n = 66). Randomization was carried out by coin flipping. One of the two impacted third molars was assigned to treatment group (Manuka honey applied just before suturing), other side to control group (nothing applied). Postsurgical pain was evaluated using visual analogue scale (VAS) of faces 7 days after extraction. The total analgesic dose used was also evaluated. Results In treatment group, postoperative VAS scores were significantly lower compared to that in control group regarding first and second days postoperatively (P \ 0.05). Total analgesic intake in the control group was significantly higher (P = 0.0001). Conclusion This study demonstrated that intrasocket application of Manuka honey after surgical extraction of impacted lower third molar is an effective method for reducing acute postsurgical pain.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Experiments showed that it is free of any type of microorganisms [13]. It has been recently used safely in many clinical studies [1][2][3][4][5][6][7][8][9][10][11][12]21]. This study agreed, where no complication occurred regarding its use.…”

Section: Discussionsupporting

confidence: 56%

Effect of Intrasocket Application of Manuka Honey on Postsurgical Pain of Impacted Mandibular Third Molars Surgery: Split-Mouth Randomized Controlled Trial

Al‐Khanati

Al-moudallal

2018

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

show abstract

“…There has furthermore been demonstrated in vitro synergism between Manuka honey and conventional antibiotics, as measured by inhibition of bacterial growth or biofilm formation [20–22]. As a topical agent, Manuka honey may be used effectively to treat disorders like atopic dermatitis, blepharitis, rhinosinusitis, and skin ulcers [23–26]. Our data corroborate the measurable antimicrobial activity of Manuka honey against a spectrum of clinical isolates from skin and soft tissue sources, including those with multi-drug resistance such as MRSA, ESBL producers, CRE, and MDR P .…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of varying UMF-graded Manuka honeys

2019

View full text Add to dashboard Cite

Honey has been used as a traditional remedy for skin and soft tissue infections due to its ability to promote wound healing. Manuka honey is recognized for its unusually abundant content of the antibacterial compound, methylglyoxal (MGO). The Unique Manuka Factor (UMF) grading system reflects the MGO concentration in Manuka honey sold commercially. Our objective was to observe if UMF values correlated with the antibacterial activity of Manuka honey against a variety of pathogens purchased over the counter. The antibacterial effect of Manuka honey with UMF values of 5+, 10+, and 15+ from the same manufacturer was assessed by the broth microdilution method. Minimum inhibitory concentration (MIC) values were determined against 128 isolates from wound cultures representing gram-positive, gram-negative, drug-susceptible, and multi-drug resistant (MDR) organisms. Lower MICs were observed with UMF 5+ honey for staphylococci (n = 73, including 25 methicillin-resistant S. aureus) and Pseudomonas aeruginosa (n = 22, including 10 MDR) compared to UMF 10+ honey (p<0.05) and with UMF 10+ compared to UMF 15+ (p = 0.01). For Enterobacteriaceae (n = 33, including 14 MDR), MIC values were significantly lower for UMF 5+ or UMF 10+ compared to UMF 15+ honey (p<0.01). MIC50 for UMF 5+, UMF 10+, and UMF 15+ honey against staphylococci was 6%, 7%, and 15%, and for Enterobacteriaceae was 21%, 21%, and 27%, respectively. For Pseudomonas aeruginosa MIC50 was 21% and MIC90 was 21–27% for all UMFs. Manuka honey exhibited antimicrobial activity against a spectrum of organisms including those with multi-drug resistance, with more potent activity overall against gram-positive than gram-negative bacteria. Manuka honey with lower UMF values, in our limited sampling, paradoxically demonstrated increased antimicrobial activity among the limited samples tested, presumably due to changes in MGO content of honey over time. The UMF value by itself may not be a reliable indicator of antibacterial effect.

show abstract

“…A 2015 Cochrane review assessed the role of honey on various types of acute and chronic wounds and found some benefit for partial thickness burns and infected post-operative wounds, though the evidence was too heterogeneous and low quality to draw any firm overall conclusions [40]. Two recent prospective randomized controlled trials in the surgical literature assessed the effect of Manuka honey on surgical scar healing but found no significant difference compared to standard treatment modalities [41,42]. The role of honey in wound management is inconclusive and further investigation is warranted.…”

Section: Post-closure Wound Carementioning

confidence: 99%

Updates in emergency department laceration management

Otterness

Singer

2019

Clin Exp Emerg Med

View full text Add to dashboard Cite

Lacerations are a common reason for patients to seek medical attention, and are often acutely managed in the emergency department. Recent studies pertaining to closure techniques, sedation and analgesia, advances in wound care, and various other topics have been published, which may enhance our understanding of this injury and improve our management practices. This article will review pertinent studies published in the past few years relevant to laceration management. Understanding the current literature and appreciating which areas warrant further investigation will help us optimize outcomes for patients who sustain laceration injuries.

show abstract

Effect of Manuka Honey on Eyelid Wound Healing: A Randomized Controlled Trial

Abstract: Upper eyelid scars treated with or without Manuka honey heal well, without significant difference when assessed by validated scar grading scales; however, honey may provide subjective benefits early, postoperatively.

Cited by 20 publications

References 18 publications

Effect of Intrasocket Application of Manuka Honey on Postsurgical Pain of Impacted Mandibular Third Molars Surgery: Split-Mouth Randomized Controlled Trial

Effect of Intrasocket Application of Manuka Honey on Postsurgical Pain of Impacted Mandibular Third Molars Surgery: Split-Mouth Randomized Controlled Trial

Antibacterial activity of varying UMF-graded Manuka honeys

Updates in emergency department laceration management

Contact Info

Product

Resources

About