Effect of malignant growth on the organ lactic dehydrogenase in the human

Hoch-Ligeti, Cornelia; Brown, Tracey; Arvin, Joan M.

doi:10.1002/1097-0142(196509)18:9<1089::aid-cncr2820180907>3.0.co;2-i

Cited by 19 publications

(4 citation statements)

References 8 publications

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“…This may be the result of diffusion, spread which as escaped histological detection, or true transformation. Similar changes in tumour free organs remote from the primary growth have been found and interpreted as due to a fundamental metabolic change (Hoch-Ligeti et al, 1965). However, an origin from destroyed microscopic tumour emboli appears possible.…”

Section: Biological Significancesupporting

confidence: 65%

Enzymes in Malignant Disease

Rosalki

1966

Proceedings of the Association of Clinical Biochemists

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Section: Biological Significancesupporting

confidence: 65%

Enzymes in Malignant Disease

Rosalki

1966

Proceedings of the Association of Clinical Biochemists

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“…There are two human LDH isoenzymes (LDHA/B) from which five homo- and heterotetramer combinations or isoforms can be inferred (LDH1 to LDH5). LDH5 is a homotetramer consisting of four identical LDHA subunits and has, for a considerable time, been discussed as a tumor marker due to the detection of elevated levels in serum of cancer patients . Besides tissue breakdown and enzyme release from tumors, overexpression and increased activity of lactate dehydrogenases in intact cancer cells directly contribute to tumor burden by fueling the rapid growth of malignant cells, even in the presence of oxygen (glycolytic phenotype).…”

Section: Introductionmentioning

confidence: 99%

“…LDH5 is a homotetramer consisting of four identical LDHA subunits and has, for a considerable time, been discussed as a tumor marker due to the detection of elevated levels in serum of cancer patients. 1 Besides tissue breakdown and enzyme release from tumors, overexpression and increased activity of lactate dehydrogenases in intact cancer cells directly contribute to tumor burden by fueling the rapid growth of malignant cells, 2 even in the presence of oxygen (glycolytic phenotype). This may also further the acidification of the tumor microenvironment, 3,4 thereby contributing to chemoresistance.…”

Section: ■ Introductionmentioning

confidence: 99%

Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A

et al. 2020

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Lactate dehydrogenase A (LDHA) is frequently overexpressed in tumors, thereby sustaining high glycolysis rates, tumor growth, and chemoresistance. High-throughput screening resulted in the identification of phthalimide and dibenzofuran derivatives as novel lactate dehydrogenase inhibitors, selectively inhibiting the activity of the LDHA isoenzyme. Cocrystallization experiments confirmed target engagement in addition to demonstrating binding to a novel allosteric binding site present in all four LDHA subunits of the LDH5 homotetramer.

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“…The measurement of LDH activities as biological markers has been employed by many investigators to differentiate the normal tissues from their malignant counterparts (3,5,19). Recently, Lee et al (8) reported that the activity of LDH and the pattern of its isoenzymes could be utilized as biological markers for normal and neoplastic mammary tissues of Sprague-Dawley females at various stages of development, and that actively growing mammary tumors were proved to exhibit an extremely high activity of LDH and an elevated portion of the muscle type of subunits.…”

Section: Resultsmentioning

confidence: 99%

Dehydrogenases in Local Carcinogenesis in Rat Mammary Gland by Dusting of Dmba-Powder

Morii

Tsubura

Takaoka

et al. 1980

Acta Histochem. Cytochem

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To the 5th right mammary gland of Sprague-Dawley female rats, ca 1 mg of DMBA was directly administered by means of a dusting of its pure powder over the mammary fatty pad. At the site of administration, a nodule of adenocarcinoma was induced more than 7 weeks after the local application with high incidence.It was enhanced more in the adults than the youngs. Histochemically, atypisms of ALP and LDH activities were observed on the apparent malignant tissues induced by DMBA-dusting. Biochemical observations on the activities of LDH and MDH and on the pattern of LDH isoenzymes were done for the induced nodules with DMBA-dusting over females aged 8-26 weeks, which were harvested 5-18 weeks after the local application. The quotients of LDH/MDH in the same sample elevated on the malignant tissues prominently owing to higher LDH activity, and the elevation was moderate on the earlier-harvested, granulomatous tissues. But, the shift toward predominance of the M type of LDH was detected distinctly in the earlier granulomatous samples harvested 5 weeks after the local application.Mammary tissues of the rat are foremost among cells of mammals in terms of susceptibility to the induction to cancer by 7,12-dimethylbenz (a) anthracene (DM BA). Mammary adenocarcinoma rapidly becomes evident in young adult SpragueDawley females administered with a pulse dose (6). But the site of initiation and early changes of carcinogenesis cannot be pointed out so soon in experiments of such systemic administration.Shinha and Dao (17) developed a technique for inducing mammary tumors by direct application of a minute quantity of DMBA. The location of early carcinogenesis might be indicated immediately after the administration of carcinogen in this experimental design. In the present paper, the mammary tumorigenesis by local application of DMBA into females aged 6-26 weeks was observed histopathologically, and then histo-and bio-chemical observations on some enzymic activities were serially done in the carcinogenesis with DMBA-dusting over the mammary fatty pads of adult females, in comparison with control mammary fatty pads, spontaneously occurring mammary fibroadenomas and induced mammary adenocarcinomas with pulse doses of DMBA.

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Effect of malignant growth on the organ lactic dehydrogenase in the human

Cited by 19 publications

References 8 publications

Enzymes in Malignant Disease

Enzymes in Malignant Disease

Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A

Dehydrogenases in Local Carcinogenesis in Rat Mammary Gland by Dusting of Dmba-Powder

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