Effect of malathion and endosulfan on brain acetylcholinesterase and ovarian steroidogenesis ofChanna punctatus (bloch)

“…The results of this study showed that serum and erythrocyte cholinesterase activities in the group exposed to Malathion were significantly less than the control group (p < 0.001), which were similar to the results of other studies. These findings confirmed the results of Inbaraj et al’s study that was performed on fish exposed to Malathion (25). They showed that Malathion demonstrated a dose-dependent inhibition of brain acetylcholinesterase activity.…”

Section: Discussionsupporting

confidence: 92%

Evaluating the protective effects of vitamin C on serum and erythrocyte cholinesterase activity of male rats exposed to malathion

Taherdehi¹,

Nikravesh²,

Jalali³

et al. 2016

Electron physician

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IntroductionMalathion is one of organophosphate poisons (OPPs) that inhibit cholinesterase activity and induce oxidative stress in target organs, such as the reproductive system. The aim of this study was to assess the effects of Malathion on serum and erythrocyte cholinesterase activity in male rats and also to assess the protective effects of vitamin C in this regard.MethodsThis experimental study was performed in the Pharmacology Laboratory of the Pharmacy Faculty and in the Advanced Histology Techniques Laboratory of the Medical Faculty of Mashhad University of Medical Sciences (MUMS) in January 2014. Thirty male wistar rats, weighting 200–250 g, were divided into five groups of six. The different groups were exposed as follows: group 1: Malathion 50 mg/kg; group 2: Vitamin C; group 3: Malathion plus Vitamin C with the specified doses; sham group: normal saline; and control group: no exposure. After six weeks, 3 ml blood samples were taken from the rats, and titrimetric and Ellman methods were used to assess serum and erythrocyte cholinesterase activity, respectively. The data was analyzed by SPSS 16, and p < 0.05 was considered significant.ResultsThe activities of serum and erythrocyte cholinesterase were inhibited significantly in the Malathion exposed group compared to the control group (p < 0.001). The administration of Vitamin C alone significantly increased the activities of serum and erythrocyte cholinesterase. The serum and erythrocyte cholinesterase inhibition showed improvement in the group that received both Malathion and Vitamin C.ConclusionMalathion reduced the activities of serum and erythrocyte cholinesterase in exposed animals. It probably has the same intoxication effects on people who are exposed. Improvement of cholinesterase activity by antioxidant effects of Vitamin C suggests that Vitamin C supplementation can be used to decrease side effects of OPP exposure.

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“…Addition of ES (in any of its forms) did not significantly alter hormone levels when compared with enzyme substrates alone (p N 0.05), indicating that the pesticide is neither interfering with the activity of the studied enzymes, nor with other enzymes downstream the sex steroid synthetic pathway, such as aromatase or 17βHSD. Contrary to the present study, Moses Inbaraj and Haider (1988) found decreased activity of 3βHSD in follicular cells of female spotted snakehead (Channa punctatus) upon exposure to waterborne ES. A decreased expression of P450c17 was reported by Fig.…”

Section: Es Does Not Act Via Inhibition Of Steroidogenic Enzymes 3βhs...contrasting

confidence: 99%

Mechanism of action of endosulfan as disruptor of gonadal steroidogenesis in the cichlid fish Cichlasoma dimerus

Cuña

Vázquez

Dorelle

et al. 2016

Comparative Biochemistry and Physiology Part C: Toxicology &

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Effect of malathion and endosulfan on brain acetylcholinesterase and ovarian steroidogenesis ofChanna punctatus (bloch)

Cited by 18 publications

References 12 publications

Novel Bioassay Based on Acetylcholinesterase and Lactate Dehydrogenase Activities to Evaluate the Toxicity of Chemicals to Soil Isopods

Novel Bioassay Based on Acetylcholinesterase and Lactate Dehydrogenase Activities to Evaluate the Toxicity of Chemicals to Soil Isopods

Evaluating the protective effects of vitamin C on serum and erythrocyte cholinesterase activity of male rats exposed to malathion

Mechanism of action of endosulfan as disruptor of gonadal steroidogenesis in the cichlid fish Cichlasoma dimerus

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