“…11,12 A large study conducted in The Gambia reported that the effects of treated mosquito nets on malaria morbidity could be augmented by chemoprophylaxis with d/p every two weeks in children. 13 Earlier studies 14,15 from this same locality indicated that chemosuppression with d/p was effective in reducing malaria morbidity and mortality.…”
Abstract. A randomized controlled trial investigated the impact of community-wide use of mosquito nets impregnated with lambda-cyhalothrin alone or with dapsone/pyrimethamine (d/p) prophylaxis on clinical malaria due to perennially transmitted Plasmodium falciparum in children in the Bo district of Sierra Leone. The 17 study communities were pair-matched and randomly allocated to receive treated mosquito nets or no nets and the children (age range ϭ 3 months-6 years) in each community were randomly allocated to receive d/p or placebo individually every two weeks. This resulted in each of the approximately 2,000 children recruited being in one of four study groups (impregnated mosquito nets and d/p prophylaxis, impregnated mosquito nets, d/p prophylaxis, and controls). The intervention phase of the study lasted 12 months. A total of 1,800 children attended more than 25% of the 48 total weekly morbidity surveillance surveys and were included in the analysis.
“…11,12 A large study conducted in The Gambia reported that the effects of treated mosquito nets on malaria morbidity could be augmented by chemoprophylaxis with d/p every two weeks in children. 13 Earlier studies 14,15 from this same locality indicated that chemosuppression with d/p was effective in reducing malaria morbidity and mortality.…”
Abstract. A randomized controlled trial investigated the impact of community-wide use of mosquito nets impregnated with lambda-cyhalothrin alone or with dapsone/pyrimethamine (d/p) prophylaxis on clinical malaria due to perennially transmitted Plasmodium falciparum in children in the Bo district of Sierra Leone. The 17 study communities were pair-matched and randomly allocated to receive treated mosquito nets or no nets and the children (age range ϭ 3 months-6 years) in each community were randomly allocated to receive d/p or placebo individually every two weeks. This resulted in each of the approximately 2,000 children recruited being in one of four study groups (impregnated mosquito nets and d/p prophylaxis, impregnated mosquito nets, d/p prophylaxis, and controls). The intervention phase of the study lasted 12 months. A total of 1,800 children attended more than 25% of the 48 total weekly morbidity surveillance surveys and were included in the analysis.
“…There is abundant evidence which supports the thesis that the anemia associated with malarial infection is attributed to the destruction of parasitized and nonparasitized erythrocytes in concert with immune and phagocytic mechanisms (6)(7)(8)(9)(10). However, since the maintenance of normal circulating erythrocyte levels in mammals is governed by the precise homeostatic balance between erythropoiesis and erythrocyte destruction (1 [1][2][3][4][5][6][7][8][9][10][11][12][13], it is conceivable that impaired erythropoiesis may also contribute to the anemic status of malaria-infected organisms. Supportive evidence has shown that during acute primary P. vivax and P. falciparum infections in humans, the proportions of marrow erythroid precursors (i.e., pronormoblasts through orthochromatophilic normoblasts) are depressed and impaired in their ability to incorporate radioiron in vitro (14,15).…”
mentioning
confidence: 93%
“…Anemia is a major pathologic consequence of malaria in humans (1)(2)(3) and in rodents (4-7). There is abundant evidence which supports the thesis that the anemia associated with malarial infection is attributed to the destruction of parasitized and nonparasitized erythrocytes in concert with immune and phagocytic mechanisms (6)(7)(8)(9)(10).…”
All rights reserved. experiments. Values in parentheses refer to the total numbers of mice per group. Statistical significance between daily control and experimental groups was assessed by the nonoparametric Mann-Whitney U test. Mice were infected on Day 0 with an intraperitoneal inoculum containing 15.0 x lo6 parasitized (P. berghei) erythrocytes.' Significantly different from daily control values ( P < 0.05).
“…The present results indicate that the improvem ent in anaemia among young children reported as a bene® t of anti-malarial intervention in short trials (Draper, 1960;Curtis et al, 1998;Prem ji et al, 1995) is likely to persist for as long as transmission can be kept low. Heavy use of chloroquine appears to have little effect on this anaemia; Hb concentrations observed in young children in the lowlands in the present study were very similar to those seen in the 1930s (Wilson, 1936).…”
Parallel monthly surveys of children aged 6-71 months were conducted in the Muheza district of Tanzania. The aim was to compare highland villages, where the mean, annual entomological inoculation rate (EIR) for malaria is 34 and mean annual prevalences of parasitaemia range from 33%-76%, with culturally similar villages of the lowlands, where the mean EIR is 405 and prevalences of parasitaemia range from 80%-84%. The total survey population could be divided into six geographical subgroups, which can be arranged in order of increasing prevalence of parasitaemia. The prevalences of dense parasitaemia, of febrile malaria, and of anaemia all increased in the same order across this series of groups, the trends being statistically significant. The results of previous studies have indicated a paradoxical effect whereby children in regions with a lower exposure to malarial infection suffer, in the long term, a higher incidence of severe attacks of malaria. In the present study there was no sign of any such paradoxical inverse relationship between the level of exposure and the prevalence of malarial illness or anaemia. However, child mortality rates are similar in the highlands and lowlands, as are the median ages of children admitted to hospital. Overall, the present findings indicate that, for the populations studied, an artificial reduction in EIR would be beneficial, even in the long term, with regard to the chronic effects of malaria. This does not necessarily conflict with previous studies reporting opposite conclusions with regard to the incidence of severe,acute effects.
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