Effect of Major Improvement in Glycemic Control on Results of Cardiovascular Function Tests in Patients with Insulin-Dependent Diabetes Mellitus

Lerman, Israel; Márquez-Murillo, Manlio F.; López-Alvarenga, Juan Carlos; Malagon, Jose; Oseguera, Jorge; León, Sergio; Sánchez-U, Tomás; Fernández, M; Gómez-Pérez, Francisco J.

doi:10.4158/ep.4.2.76

Cited by 2 publications

(2 citation statements)

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“…Although animal studies have demonstrated a beneficial effect of improved glycemic control on myocardial function (8,13), studies in humans have not been consistent (14)(15)(16)(17). There was no difference in the systolic function as studied by radionuclide ventriculography between 8 patients with type 1 diabetes and 11 control subjects (15).…”

Section: Full Cohortmentioning

confidence: 95%

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Two years of intensive glycemic control and left ventricular function in the Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus (VA CSDM).

et al. 2000

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RESULTS -There was no difference in the mean LV ejection fraction (at entry: STD 57.1 ± 9.51%; INT 58.1 ± 8.7%; at 24 months: STD 57.3 ± 10.8%, INT 59.5 ± 10.7%), peak filling rate (at entry: STD 2.6 ± 0.7 end diastolic volume per second, INT 2.4 ± 0.8 end diastolic volume per second; at 24 months: STD 2.7 ± 1.0 end diastolic volume per second, INT 2.5 ± 0.7 end diastolic volume per second), or time to peak filling rate (at entry: STD 195.3 ± 69.5 ms, INT 185.6 ± 62.4 ms; at 24 months: STD 182.6 ± 64.8 ms, INT 179.2 ± 61.2 ms) between the 2 treatment arms. A subgroup analysis of 104 patients (STD, n = 53; INT, n = 51) that omitted individuals with intervening cardiac events/revascularization or a change in cardioactive medications also showed no difference in the LV function at entry and at 24 months between the 2 groups. Abnormal LV ejection fraction at baseline predicted cardiac events (interval between cardiac beats [RR] = 2.5).CONCLUSIONS -Two years of intensive glycemic control does not affect the LV systolic or diastolic function in patients with type 2 diabetes.

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Section: Full Cohortmentioning

confidence: 95%

“…The impairment of diastolic function is noted to be more pronounced in patients with type 2 diabetes than in those with type 1 diabetes (17,18). Lerman et al (14) found no significant change in the LV diastolic function after 4 weeks of intensive glycemic control with insulin therapy in 8 type 1 diabetic patients.…”

Section: Full Cohortmentioning

confidence: 98%