Effect of magnesium sulfate on contractile force and intracellular calcium concentration in pregnant human myometrium

Fomin, Victor P.; Gibbs, Shawn G.; Vanam, Ram; Morimiya, Akira; Hurd, William W.

doi:10.1016/j.ajog.2005.11.045

Cited by 38 publications

(25 citation statements)

References 13 publications

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“…This most likely reflects the ability of oxytocin to induce and augment uterine contractions even in the presence of magnesium. [37][38][39] No correlation was observed with elevated serum UA and blood loss, as determined by a change in hematocrit or the need for blood transfusion. This result was not surprising, given that estimations of blood loss are notably subjective and inaccurate 40,41 and uterine atony often occurs in the absence of recognized risk factors.…”

Section: Discussionmentioning

confidence: 61%

Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery

Kovacheva¹,

Soens²,

Tsen³

2013

International Journal of Obstetric Anesthesia

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Section: Discussionmentioning

confidence: 61%

Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery

Kovacheva¹,

Soens²,

Tsen³

2013

International Journal of Obstetric Anesthesia

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“…The basis for its use as a tocolytic is due to the observed effects of Mg in reducing myometrial contractility through extra-and intracellular mechanisms of action [30][31][32][33] . Its most widely recognized and well studied role in the brain is in relation to the NMDA glutamate receptor ion channel where it performs a physiological blocking action that prevents ion flow through the channel under conditions of normal membrane polarization.…”

mentioning

confidence: 99%

High Dose Magnesium Sulfate Exposure Induces Apoptotic Cell Death in the Developing Neonatal Mouse Brain

Dribben¹,

Creeley

Wang

et al. 2009

Neonatology

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Background: Magnesium sulfate (MgSO₄) is often used as a treatment for pre-eclampsia/eclampsia and preterm labor, resulting in the exposure of a significant number of neonates to this drug despite a lack of evidence suggesting that it is safe, or effective as a tocolytic. While there is evidence that MgSO₄ may be neuroprotective in perinatal brain injury, recent reviews have suggested that the effects are dependent upon dose, and that higher doses may actually increase neonatal morbidity and mortality. There is a lack of evidence investigating the neurotoxic effects of neonatal magnesium (Mg) exposure on the developing brain, specifically in terms of neurodevelopmental apoptosis, a cell-killing phenomenon known to be potentiated by other drugs with mechanisms of action at Mg-binding sites (i.e. NMDA receptor antagonists such as MK-801, ketamine, and PCP). Objective: To investigate the effects of Mg exposure on the neonatal mouse brain at different postnatal ages to determine whether MgSO₄ treatment causes significant cell death in the developing mouse brain. Methods: C57Bl/6 mice were treated with four doses of MgSO₄ (250 mg/kg) on postnatal days 3 (P3), 7 (P7) or 14 (P14). Caspase-3 immunohistochemistry, cupric silver staining, and electron microscopy techniques were used to examine Mg-treated brains for neurotoxic effects. Results: Qualitative evaluation using cupric silver staining revealed widespread damage throughout the brain in P7 animals. Results of electron microscopy confirmed that the cell death process was apoptotic in nature. Quantitative evaluation of damage to the cortex, caudate-putamen, hippocampus, thalamus, and cerebellum showed that Mg treatment caused significant brain damage in animals treated on P3 and P7, but not P14. Conclusions: Administration of high doses of Mg may be detrimental to the fetal brain, particularly if exposure occurs during critical periods of neurodevelopment.

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“…32 In vitro studies using human myometrial strips suggest that the tocolytic effect of magnesium sulfate at pharmacologic dose (5 mmol/L) is through decreasing calcium influx and release from myometrial cells. 33 We acknowledge the limitations to our study mentioned previously. In addition, differences among the three study groups with respect to number of prior CDs (P=0.017) may have affected the uterine tone achieved.…”

Section: Discussionmentioning

confidence: 95%

The effect of co-administration of intravenous calcium chloride and oxytocin on maternal hemodynamics and uterine tone following cesarean delivery: a double-blinded, randomized, placebo-controlled trial

Farber

Schultz

Lugo

et al. 2015

International Journal of Obstetric Anesthesia

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Effect of magnesium sulfate on contractile force and intracellular calcium concentration in pregnant human myometrium

Cited by 38 publications

References 13 publications

Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery

Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery

High Dose Magnesium Sulfate Exposure Induces Apoptotic Cell Death in the Developing Neonatal Mouse Brain

The effect of co-administration of intravenous calcium chloride and oxytocin on maternal hemodynamics and uterine tone following cesarean delivery: a double-blinded, randomized, placebo-controlled trial

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