Abstract:Smooth muscle function, including that of the bladder, is mediated by changes in the intracellular concentration of calcium. Magnesium modulates the transport of calcium and may modify bladder function. This study was designed to investigate the effect of magnesium on the response of rabbit whole bladder to field stimulation in vitro. The response to field stimulation was decreased by magnesium in a concentration-dependent manner. Verapamil significantly enhanced the suppressive effect of magnesium, whereas BA… Show more
These results demonstrate that L-type Ca(2+) channels are functionally expressed in rabbit basilar smooth muscle cells and suggest that L-type Ca(2+) channels may play a pivotal role for magnesium-induced relaxation.
These results demonstrate that L-type Ca(2+) channels are functionally expressed in rabbit basilar smooth muscle cells and suggest that L-type Ca(2+) channels may play a pivotal role for magnesium-induced relaxation.
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