Effect of magnesium ion (Mg2+) substitution and calcination to the properties of biphasic calcium phosphate (BCP)

Marahat, Muhammad Hanif; Zahari, Mohamad Abdul Aziz; Mohamad, Hasmaliza; Kasim, Shah Rizal

doi:10.1063/1.5089373

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Another evidence of the formation of pure WH phase could be associated with the presence of 0210 peak in WH-6 and WH-11 (discussed later), a characteristic peak of WH. The reduction in d-spacing values (from 2.60 to 2.58 at 34.7°) of WH-6 and WH-11 also confirmed the precipitation of pure WH phase [1,[44][45][46]. Moreover, the absence of peaks at the 001 face and at 31.2° and 31.8° of β-TCP and hydroxyapatite have demonstrated another evidence of the purity of WH-6 phase [47].…”

Section: Resultsmentioning

confidence: 57%

Synthesis, Characterization and Process Optimization of Bone Whitlockite

et al. 2020

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Whitlockite, being the second most abundant bio-mineral in living bone, finds huge applications in tissue regeneration and implants and its synthesis into its pure form has remained a challenge. Although precipitation of whitlockite phase has been reported recently in many publications, effects of various parameters to control such phase as well as conditions for the bulk preparation of this extremely important bio-mineral have not been investigated so far. In this work, we report the precipitation of pure whitlockite phase using common precursors. As reported in the literature, whitlockite is stable in a narrow pH range, therefore; optimization of pH for the stabilization of whitlockite phase has been investigated. Additionally, in order to narrow down the optimum conditions for the whitlockite precipitation, effect of temperature and heating conditions has also been studied. The obtained solids were characterized using powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). From PXRD analysis, it was observed that heating the precursor’s mixture at 100 °C with subsequent aging at the optimized pH resulted in the precipitation of pure whitlockite phase. These results were further confirmed by TGA, SEM and Raman spectroscopy analysis and it was confirmed that the conditions reported here favor whitlockite precipitation without formation of any secondary phase. These reaction conditions were further confirmed by changing all the parameters like aging, heating time, feed rate of precursors one by one. From PXRD analysis of these samples, it was concluded that not only pH but temperature, heating time, aging time and feed rate effect simultaneously on the precipitation of pure whitlockite phase and a subtle change in any of these parameters could lead to the formation of undesired stable secondary calcium phosphate phases.

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