Effect of magnesium ion incorporation on the thermal stability, dissolution behavior and bioactivity in Bioglass-derived glasses

Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation

“…As for direct CaP precipitation, many studies have sought to unveil the in vitro HCA formation processes from silicate-based BGs [ 2 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], as well as their relationship to the glass composition and structure [ 2 , 3 , 29 , 40 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Here the glass is typically immersed in an acellular simulated body fluid ( SBF ) solution that matches the concentrations of inorganic species in human plasma [ 56 , 57 ].…”

“…Notably, much of the literature on apatite formation from BGs is overall vague as to the details of this amorphous “CaO–P O -rich film” [ 2 ], whose precise chemical/structural nature is challenging to characterize experimentally. Yet, recent solid-state H/ P NMR studies [ 36 , 37 , 38 , 39 , 40 , 44 ] of the amorphous portion of the in vitro-formed CaP surface layer (a.k.a. the “CaO–P O -rich film”) reveal very similar NMR parameters with those reported from ACP precipitated from calcium phosphate solutions [ 20 , 21 , 22 , 59 , 60 ].…”

“…the “CaO–P O -rich film”) reveal very similar NMR parameters with those reported from ACP precipitated from calcium phosphate solutions [ 20 , 21 , 22 , 59 , 60 ]. Notwithstanding that many researchers in the BG community do identify the “CaO–P O -rich film” with “ACP” [ 37 , 38 , 39 , 40 , 41 , 42 , 44 , 45 , 46 , 47 , 61 ], this salient feature appears not to be widely recognized.…”

Composition-dependent in vitro apatite formation at mesoporous bioactive glass-surfaces quantified by solid-state NMR and powder XRD

“…While both the sol-gel/EISA routes yield porous structures associated with large surface areas, the EISA-derived mesoporous bioactive glasses (MBGs) 5-8 feature ordered mesoporous networks that is believed to accelerate the HCA formation rate, i.e., the "bioactivity" of the material. [18][19][20][21][22][23][24] Such studies are often complemented by measuring the concentrations of Ca, P, and Si in the solution after the SBF-exposure of the (M)BG; this typically reveals an initial elevation of the Ca and P concentrations (stemming from the (M)BG dissolution), followed by their reduction during the subsequent ACP/HCA formation processes. [11][12][13] The "in vitro bioactivity" of a given (M)BG specimen is normally evaluated by monitoring the onset of HCA formation, and qualitatively assessing the amount thereof when the biomaterial is immersed in a simulated body fluid (SBF) for progressively increased intervals.…”

Impact of iron chelators on short-term dissolution of basaltic glass

“…These experiments were performed in pure water, water enriched in elements from the glass (Luckscheiter and Nesovic, 2004;Thien et al, 2012) and in salt solutions (Godon et al, 1988;Abdelouas et al, 1993). The stability and dissolution behavior of bioglass, designed to form chemical bonds with living tissues (Souza et al, 2013), is of interest to the medical field. Glass alteration is also a crucial issue in the field of cultural heritage, especially with respect to the restoration and conservation of stained glass windows (see, for example Silvestri et al, 2005;Warkinson et al, 2005;Cagno et al, 2011;Gentaz, 2011;Schalm et al, 2010;Sterpenich, 2011;Lombardo et al, 2013).…”