Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) β-cell line

Elhassan, Safa Abdelgadir Mohamed; Candasamy, Mayuren; Ching, Tan Swee; Heng, Yap Kah; Bhattamisra, Subrat Kumar

doi:10.1080/14786419.2019.1696794

Cited by 8 publications

(5 citation statements)

References 12 publications

(4 reference statements)

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“…128 Madecassoside improves insulin sensitivity in pancreatic cells to promote glucose-stimulated insulin secretion (GSIS) and to enhance expression of insulin signalling proteins without any cytotoxic effects, making it a favourable drug compound in targeting type 2 diabetes mellitus. 129…”

Section: Miscell Aneous Ac Tivitie Smentioning

confidence: 99%

“…Asiaticoside is proved to protect against mild acute pancreatitis (MAP) in caerulein‐induced MAP models by inhibiting pancreatic acinar cells necrosis, ameliorating pancreatitis‐associated histopathological changes, and lowering the severity of pancreatic tissue injury as well as pancreatitis‐associated lung injury in a severe acute pancreatitis model 128 . Madecassoside improves insulin sensitivity in pancreatic cells to promote glucose‐stimulated insulin secretion (GSIS) and to enhance expression of insulin signalling proteins without any cytotoxic effects, making it a favourable drug compound in targeting type 2 diabetes mellitus 129 …”

Section: Miscellaneous Activitiesmentioning

confidence: 99%

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Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review

Bandopadhyay

Mandal

Ghorai

et al. 2023

J Cellular Molecular Medi

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Centella asiatica is an ethnomedicinal herbaceous species that grows abundantly in tropical and sub‐tropical regions of China, India, South‐Eastern Asia and Africa. It is a popular nutraceutical that is employed in various forms of clinical and cosmetic treatments. C. asiatica extracts are reported widely in Ayurvedic and Chinese traditional medicine to boost memory, prevent cognitive deficits and improve brain functions. The major bioactive constituents of C. asiatica are the pentacyclic triterpenoid glycosides, asiaticoside and madecassoside, and their corresponding aglycones, asiatic acid and madecassic acid. Asiaticoside and madecassoside have been identified as the marker compounds of C. asiatica in the Chinese Pharmacopoeia and these triterpene compounds offer a wide range of pharmacological properties, including neuroprotective, cardioprotective, hepatoprotective, wound healing, anti‐inflammatory, anti‐oxidant, anti‐allergic, anti‐depressant, anxiolytic, antifibrotic, antibacterial, anti‐arthritic, anti‐tumour and immunomodulatory activities. Asiaticoside and madecassoside are also used extensively in treating skin abnormalities, burn injuries, ischaemia, ulcers, asthma, lupus, psoriasis and scleroderma. Besides medicinal applications, these phytocompounds are considered cosmetically beneficial for their role in anti‐ageing, skin hydration, collagen synthesis, UV protection and curing scars. Existing reports and experimental studies on these compounds between 2005 and 2022 have been selectively reviewed in this article to provide a comprehensive overview of the numerous therapeutic advantages of asiaticoside and madecassoside and their potential roles in the medical future.

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Section: Miscell Aneous Ac Tivitie Smentioning

confidence: 99%

Section: Miscellaneous Activitiesmentioning

confidence: 99%

Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review

Bandopadhyay

Mandal

Ghorai

et al. 2023

J Cellular Molecular Medi

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“…On the contrary, catalpol (30 mM) significantly increased the p-IRS, PI3K, p-AKT, and AKT proteins in HG-treated INS-1E cells. Thus, catalpol could ameliorate insulin sensitivity through the insulin-signaling pathway in β-cells [ 63 , 64 ]. Moreover, catalpol may act against T2DM-induced oxidative damage in pancreatic islet cells of HFD/STZ rats through antioxidant effects.…”

Section: Effects Of Catalpol In Diabetes Mellitusmentioning

confidence: 99%

Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and Its Complications

et al. 2021

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Catalpol isolated from Rehmannia glutinosa is a potent antioxidant and investigated against many disorders. This review appraises the key molecular pathways of catalpol against diabetes mellitus and its complications. Multiple search engines including Google Scholar, PubMed, and Science Direct were used to retrieve publications containing the keywords “Catalpol”, “Type 1 diabetes mellitus”, “Type 2 diabetes mellitus”, and “diabetic complications”. Catalpol promotes IRS-1/PI3K/AKT/GLUT2 activity and suppresses Phosphoenolpyruvate carboxykinase (PEPCK) and Glucose 6-phosphatase (G6Pase) expression in the liver. Catalpol induces myogenesis by increasing MyoD/MyoG/MHC expression and improves mitochondria function through the AMPK/PGC-1α/PPAR-γ and TFAM signaling in skeletal muscles. Catalpol downregulates the pro-inflammatory markers and upregulates the anti-inflammatory markers in adipose tissues. Catalpol exerts antioxidant properties through increasing superoxide dismutase (sod), catalase (cat), and glutathione peroxidase (gsh-px) activity in the pancreas and liver. Catalpol has been shown to have anti-oxidative, anti-inflammatory, anti-apoptosis, and anti-fibrosis properties that in turn bring beneficial effects in diabetic complications. Its nephroprotective effect is related to the modulation of the AGE/RAGE/NF-κB and TGF-β/smad2/3 pathways. Catalpol produces a neuroprotective effect by increasing the expression of protein Kinase-C (PKC) and Cav-1. Furthermore, catalpol exhibits a cardioprotective effect through the apelin/APJ and ROS/NF-κB/Neat1 pathway. Catalpol stimulates proliferation and differentiation of osteoblast cells in high glucose condition. Lastly, catalpol shows its potential in preventing neurodegeneration in the retina with NF-κB downregulation. Overall, catalpol exhibits numerous beneficial effects on diabetes mellitus and diabetic complications.

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“…Previous studies have confirmed that MA can be widely distributed to several internal organs, and reach a maximum level within 5–15 min after oral administration, however, the bioavailability of oral intake of MA is poor (less than 1%) ( 11 , 12 ). Although many beneficial effects associated with MA, such as it can promote wound healing ( 13 ), ameliorate lung fibrosis in mice ( 14 ), inhibit proliferation and invasion of liver cancer cells ( 15 ), prevent neurodegenerative diseases ( 16 ), stimulate insulin secretion ( 17 ), and relieve osteoarthritis ( 18 ) have been reported, research on the effects of MA on obesity has not yet been developed, and so this study aimed to evaluate the interplay between obesity and MA and the possible underlying molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Madecassoside Inhibits Body Weight Gain via Modulating SIRT1-AMPK Signaling Pathway and Activating Genes Related to Thermogenesis

et al. 2021

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BackgroundPre-clinical research studies have shown that Madecassoside (MA) has favorable therapeutic effects on arthritis, acne, vitiligo and other diseases. However, the effects of MA on obesity have not yet been studied. This study mainly aimed to investigate the effects of MA in protecting against obesity and its underlying mechanism in reducing obesity.MethodsObese diabetic KKay/TaJcl mice model was adopted to the study. The body weight of all animals was recorded daily, and the blood glucose, blood lipid, and serum aminotransferase levels were examined, respectively. The expression of P-AMPK, SIRT1, P-LKB1, P-ACC, and P-HSL in abdominal fat, mesenteric fat, and epididymal fat was measured by western blotting, and the levels of PPARα, CPT1a, PGC-1α, UCP-1, Cidea, Cox7a1, and Cox8b were examined by real-time quantitative PCR (RT-qPCR).ResultsThe results revealed that the body weight of the mice in MA group was significantly reduced, and the body mass index (BMI) showed significant difference between the two groups after 8 weeks of MA treatment. Further research revealed that it affected the mesenteric fat and epididymis fat by activating SIRT1/AMPK signaling pathway, and then promoted fatty acid oxidation of epididymal fat (PPARα ↑, CPT1a↑, and PGC-1α↑). Last but not the least, it also promoted the expression of UCP-1 and stimulated thermoregulatory genes (Cidea, Cox7a1, and Cox8b) in brown fat and mesenteric fat.ConclusionsTaken together, these findings suggest that MA can inhibit the weight gain in obese diabetic mice, and reduce triglyceride levels, inhibit lipogenesis of mesenteric fat, promote epididymal fat lipolysis and fatty acid oxidation. Furthermore, MA treatment might promote mesenteric fat browning and activate mitochondrial function in brown fat as well as mesenteric fat.

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Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) β-cell line

Cited by 8 publications

References 12 publications

Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review

Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review

Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and Its Complications

Madecassoside Inhibits Body Weight Gain via Modulating SIRT1-AMPK Signaling Pathway and Activating Genes Related to Thermogenesis

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